Your browser doesn't support javascript.
loading
Show: 20 | 50 | 100
Results 1 - 20 de 20
Filter
1.
Childs Nerv Syst ; 37(1): 211-215, 2021 01.
Article in English | MEDLINE | ID: mdl-32661646

ABSTRACT

BACKGROUND: Acute flaccid myelitis (AFM) syndrome consists of loss of lower motor neurons following a viral infection, with preserved sensory function. It usually affects the upper limbs asymmetrically, with proximal more than distal muscle involvement. METHODS: Five cases were surgically treated with nerve transfers: spinal accessory to suprascapular nerve transfer (4 patients), branch of radial nerve to axillary nerve transfer (Somsak's procedure) (2 patients), and transfer of a fascicle of the ulnar nerve to the motor branch to the biceps (Oberlin's procedure) (1 patient). RESULTS: Motor improvement was seen in three cases. Widespread motor involvement was associated with poor outcome. CONCLUSION: This small series of cases reinforces that nerve transfers are a reliable option for treatment of selected children with AFM.


Subject(s)
Central Nervous System Viral Diseases , Myelitis , Nerve Transfer , Neuromuscular Diseases , Child , Humans , Myelitis/surgery , Ulnar Nerve
2.
Acta Neurochir (Wien) ; 151(9): 1089-98, 2009 Sep.
Article in English | MEDLINE | ID: mdl-19448970

ABSTRACT

BACKGROUND: Tumours of the brachial plexus region are rare and most publications are case reports or studies with a small series of patients. The aim of this study is to present our experience in managing these lesions. METHODS: We review 18 patients with tumours in the brachial plexus region submitted to surgical treatment in a 6 year period, including their clinical presentation, neuro-imaging data, surgical findings and outcome. FINDINGS: The tumours comprised a heterogeneous group of lesions, including schwannomas, neurofibromas, malignant peripheral nerve sheath tumour (MPNST), sarcomas, metastases, desmoids and an aneurysmal bone cyst. The most common presentation was an expanding lump (83.33%). Eleven tumours were benign and 7 were malignant. Neurofibromatosis was present in only 2 patients (11.11%). Gross total resection was achieved in 14 patients and sub-total resection in the others. Only 3 patients presented with new post-operative motor deficits. The incidence of complications was low (16.5 %). CONCLUSIONS: The majority of tumours were benign and most of them could be excised with a low incidence of additional deficits. Some of the malignant tumours could be controlled by surgery plus adjuvant therapy, but this category is still associated with high morbidity and mortality rates.


Subject(s)
Brachial Plexus Neuropathies/diagnosis , Brachial Plexus Neuropathies/surgery , Brachial Plexus/pathology , Brachial Plexus/surgery , Peripheral Nervous System Neoplasms/diagnosis , Peripheral Nervous System Neoplasms/surgery , Adolescent , Adult , Bone Cysts, Aneurysmal/diagnosis , Bone Cysts, Aneurysmal/pathology , Bone Cysts, Aneurysmal/surgery , Brachial Plexus/physiopathology , Brachial Plexus Neuropathies/physiopathology , Child , Female , Fibromatosis, Aggressive/diagnosis , Fibromatosis, Aggressive/physiopathology , Fibromatosis, Aggressive/surgery , Humans , Magnetic Resonance Imaging , Male , Middle Aged , Neoplasm Metastasis/diagnosis , Neoplasm Metastasis/physiopathology , Neoplasm Recurrence, Local/epidemiology , Nerve Sheath Neoplasms/diagnosis , Nerve Sheath Neoplasms/physiopathology , Nerve Sheath Neoplasms/surgery , Neurilemmoma/diagnosis , Neurilemmoma/physiopathology , Neurilemmoma/surgery , Neurofibroma/diagnosis , Neurofibroma/physiopathology , Neurofibroma/surgery , Neurosurgical Procedures , Pain/etiology , Paresthesia/etiology , Peripheral Nervous System Neoplasms/physiopathology , Postoperative Complications/epidemiology , Retrospective Studies , Sarcoma/diagnosis , Sarcoma/physiopathology , Sarcoma/surgery , Tomography, X-Ray Computed , Treatment Outcome , Young Adult
3.
Clin Neurol Neurosurg ; 110(1): 38-45, 2008 Jan.
Article in English | MEDLINE | ID: mdl-17920190

ABSTRACT

OBJECTIVE: To compare clinical evaluation, electrophysiological investigation and magnetic resonance findings in assessing the severity of idiopathic carpal tunnel syndrome. PATIENTS AND METHODS: Seventy-four patients with idiopathic carpal tunnel syndrome were prospectively recruited. Clinical evaluation included symptoms severity score and two-point discrimination, sensory and motor nerve conduction velocities were determined by electroneuromyography and imaging parameters were obtained after wrist magnetic resonance. The Wilcoxon test was used to define the differences between measurements of median nerve area. The Pearson and Spearman correlation tests were used to determine the relationships between all the measured parameters. RESULTS: Cross-sectional area of median nerve was smaller at hamate level than at radio-ulnar joint and pisiform levels (p<0.001). With exception of median nerve area at hamate level, there was a lower degree of correlation between MRI parameters and findings obtained by clinical assessments and electrophysiological measurements. The median nerve area at hamate level correlated negatively with duration of symptoms, two-point discrimination, symptoms severity score and positively with sensory nerve conduction velocity (p<0.01). CONCLUSION: In patients with idiopathic carpal tunnel syndrome, median nerve area measured by wrist magnetic resonance at hamate level may be considered as a valuable indicator to grading the severity of disease.


Subject(s)
Carpal Tunnel Syndrome/pathology , Carpal Tunnel Syndrome/physiopathology , Median Nerve/pathology , Neural Conduction/physiology , Ulnar Nerve/pathology , Action Potentials/physiology , Adult , Age Factors , Aged , Body Mass Index , Carpal Tunnel Syndrome/complications , Female , Humans , Magnetic Resonance Imaging , Male , Median Nerve/physiopathology , Middle Aged , Ulnar Nerve/physiopathology
4.
Neurol Sci ; 25(4): 216-9, 2004 Oct.
Article in English | MEDLINE | ID: mdl-15549507

ABSTRACT

Leprosy is an infectious disease of prevalence still high in endemic areas in Brazil. The neurological presentation depends on the involved nerve and is usually associated with skin lesions and the formation of multiple abscesses. We present a case of isolated tuberculoid leprosy, discuss the occurrence, the differential diagnosis and the treatment of this rare presentation and reaffirm the importance of considering leprosy in the differential diagnosis of patients with polyneuropathy or nerve enlargement with no skin lesions.


Subject(s)
Forearm/innervation , Forearm/pathology , Leprosy, Tuberculoid/pathology , Peripheral Nervous System Diseases/microbiology , Peripheral Nervous System Diseases/pathology , Adult , Antibiotics, Antitubercular/therapeutic use , Brazil , Dapsone/therapeutic use , Granuloma/microbiology , Granuloma/pathology , Granuloma/physiopathology , Humans , Leprostatic Agents/therapeutic use , Leprosy, Tuberculoid/microbiology , Leprosy, Tuberculoid/physiopathology , Male , Peripheral Nervous System Diseases/physiopathology , Rifampin/therapeutic use , Treatment Outcome
5.
Surg Neurol ; 60(2): 98-104; discussion 104, 2003 Aug.
Article in English | MEDLINE | ID: mdl-12900108

ABSTRACT

BACKGROUND: In an attempt to evaluate the predictive factors of morbidity and mortality in patients who suffered from civilian gunshot wounds to the head, we reviewed a series of 319 patients admitted to the Hospital Santa Marcelina, São Paulo, Brazil, between 1994 and 2000. METHODS: Clinical and cranial computed tomography (CT) results are described. The initial Glasgow Coma Scale (GCS), the presence of an unilateral dilated pupil or medium fixed pupils, and five different findings in the CT scan were considered as variables. The Qui-Square Fisher test was utilized to verify the correlation between the presence of the variables and the occurrence of an increased mortality rate and of an unfavorable outcome (Glasgow Outcome Scale = 2 and 3). RESULTS: In 265 cases the missile penetrated the dura (83%). In our study there was a significant correlation between the low GCS scores on admission and a higher mortality (p < 0.001). This kind of correlation was also noted with patients admitted with unilateral dilated pupil and medium fixed pupil. There were 187 patients (70.5%) evaluated by CT scan. There was a significant correlation between the presence of transventricular or bihemispheric central type trajectory and high mortality. The patients admitted with unilobar supratentorial wounds resulted in better outcome when compared to those with bilobar or multilobar wounds (p < 0.001). A group of 156 patients was submitted to an aggressive surgical protocol. The best results were seen in patients admitted with initial GCS score higher than 8. CONCLUSIONS: We conclude that low GCS scores at admission, unilateral dilated pupil or medium fixed pupil, transventricular or bihemispheric central type trajectory, and bilobar or multilobar wounds noted through CT scan are predictive factors of high morbidity and mortality in patients with gunshot wounds to the head, in our clinical experience. We also conclude that surgical treatment is not recommended for patients with penetrating wounds and GCS score of 3 to 5 in the absence of hematoma causing a mass effect.


Subject(s)
Brain Injuries/surgery , Wounds, Gunshot/surgery , Adolescent , Adult , Aged , Brain Injuries/complications , Brain Injuries/mortality , Brain Injuries/physiopathology , Brazil/epidemiology , Child , Child, Preschool , Disabled Persons/statistics & numerical data , Female , Glasgow Coma Scale , Humans , Male , Middle Aged , Prognosis , Retrospective Studies , Risk Factors , Survival Analysis , Treatment Outcome , Wounds, Gunshot/complications , Wounds, Gunshot/mortality , Wounds, Gunshot/physiopathology
6.
Arq Neuropsiquiatr ; 59(2-B): 421-3, 2001 Jun.
Article in English | MEDLINE | ID: mdl-11460191

ABSTRACT

Intranasal schwannomas are rare lesions, specially when they present with an intracranial extension. The fifth case in the medical literature of a naso-ethmoid schwannoma with extension into the anterior cranial fossa is presented. The magnetic resonance findings and the details of the combined intracranial / transfacial operative approach used are described. The possible origin and the clinical characteristics of this rare lesion are reviewed.


Subject(s)
Ethmoid Sinus , Neurilemmoma/diagnosis , Paranasal Sinus Neoplasms/diagnosis , Skull Neoplasms/diagnosis , Adult , Ethmoid Sinus/pathology , Ethmoid Sinus/surgery , Female , Humans , Magnetic Resonance Imaging , Neurilemmoma/pathology , Neurilemmoma/surgery , Paranasal Sinus Neoplasms/pathology , Paranasal Sinus Neoplasms/surgery , Skull Neoplasms/pathology , Skull Neoplasms/surgery
7.
Arq Neuropsiquiatr ; 58(3A): 760-3, 2000 Sep.
Article in Portuguese | MEDLINE | ID: mdl-10973124

ABSTRACT

Intraspinal dermoid tumor and diastematomyelia is a rare combination of pathologies and only eight cases were priorly published. We report a new case in an adult with clinical presentation of progressive paresis and sensitive deficit in the lower limbs, associated with a thoraco-lombar kyphoscoliosis. The diagnosis based on the CT scan and MR images was confirmed at surgery. Pathophysiologic and clinical aspects as well as the radiological characteristics of these pathologies are dicussed and the importance of the early diagnosis is emphasized.


Subject(s)
Dermoid Cyst/complications , Neural Tube Defects/complications , Spinal Cord Neoplasms/complications , Adult , Dermoid Cyst/surgery , Follow-Up Studies , Humans , Magnetic Resonance Imaging , Male , Neural Tube Defects/surgery , Spinal Cord Neoplasms/surgery
8.
Ann Otol Rhinol Laryngol ; 106(11): 927-33, 1997 Nov.
Article in English | MEDLINE | ID: mdl-9373083

ABSTRACT

In spite of increasing experience with skull base surgery, some of the guidelines for indications for operations may vary according to the institution. One-hundred two patients underwent craniofacial oncologic resections at our institution from 1982 to 1995. A retrospective analysis of the indications for and contraindications to these procedures was undertaken. The main indications for malignant tumors were skin lesions with direct invasion of the anterior or lateral skull base (69%) and nasal-paranasal sinus tumors (21%). The main indications for benign tumors were glomus lesions (26%), menigiomas (22%), and fibro-osseous lesions of the anterior skull base (19%). The main contraindications were extensive invasion of the central nervous system, invasion of the cavernous sinus and/or internal carotid artery by aggressive malignancies, and bilateral orbital invasion in a nonblind patient. Also, 6 patients had their procedures interrupted during craniotomy for several reasons - extensive central nervous system invasion (2 cases), bilateral orbital invasion (1), lack of brain retraction (1), lack of histologic diagnosis during the operation (1), and purulent discharge at the frontal sinus (1). Craniofacial oncologic operations are extensive surgical procedures that have to be properly indicated in order to obtain low levels of morbidity and mortality. The selection of cases is of paramount importance. In some instances, it seems advisable even to interrupt these operations in the first phase.


Subject(s)
Craniotomy/methods , Patient Selection , Skull Base Neoplasms/surgery , Adult , Contraindications , Craniotomy/adverse effects , Female , Humans , Male , Middle Aged , Reoperation , Retrospective Studies , Skull Base Neoplasms/diagnostic imaging , Skull Base Neoplasms/pathology , Tomography, X-Ray Computed
9.
Acta Neurochir (Wien) ; 139(6): 487-506, 1997.
Article in English | MEDLINE | ID: mdl-9248582

ABSTRACT

Surgical indications for arteriovenous malformations (AVMs) arising at the region of the basal ganglia are questionable and the majority of cases are considered inoperable. Albeit not free from risks of morbidity and mortality, the treatment of choice is usually radiosurgery for small lesions, and embolization plus radiosurgery for larger lesions. Nevertheless, some lesions may be amenable for surgical resection due to their favorable location. Eighteen cases of such AVMs were selected for a direct approach in our series. Seventeen cases were classified as Spetzler and Martin [22] grade III, and one case was a grade V. Ten patients were males and eight females. The mean age was 28.3 years (ranged from 2 to 43 years). Sixteen patients had had previous hemorrhagic events prior to hospital admission. Eleven patients had pre-operative well established neurological deficits, and seven patients although symptomatic had a normal neurological exam at admission. Fifteen patients had their AVMs completely resected. Among the eleven patients with previous neurological deficits nine had no change in their pre-operative condition and two experienced postoperative neurological worsening. In the long-term follow-up six patients had a complete recovery and five recovered only partially. Among the seven patients whose neurological examination was normal pre-operatively five remained unchanged, one had a transient motor deficit, and one died due to a thalamic venous infarction and massive bleeding into the thalamus. The anatomical knowledge and the precise localization of the arteriovenous malformation through the aid of neuroimage studies has provided the means to classify these AVMs and plan operative strategies for some small selected cases with relatively low morbidity.


Subject(s)
Basal Ganglia/surgery , Intracranial Arteriovenous Malformations/surgery , Adolescent , Adult , Basal Ganglia/pathology , Cerebral Angiography , Child , Child, Preschool , Female , Humans , Intracranial Arteriovenous Malformations/pathology , Male
10.
Acta Neurochir (Wien) ; 139(4): 325-31, 1997.
Article in English | MEDLINE | ID: mdl-9202772

ABSTRACT

In a period of 10 years fifteen patients bearing sixteen aneurysms arising at the posterior cerebral artery were operated at our institution. Based on the approaches selected for each location a division of the posterior cerebral artery into three surgical segments is proposed. The first segment (S1), or anterior extends from the basilar artery bifurcation to the point where the artery reaches the level of the most lateral edge of the cerebral peduncle, the second segment (S2), or middle extends from the posterior limit of S1 to a point located just before the most medial extent of the artery in the quadrigeminal cistern (collicular point), and the third segment (S3), or posterior corresponds to the collicular point and to the portions of the posterior cerebral artery distal to it. Utilizing the concept of surgical segments all aneurysms in our series were satisfactorily exposed. Those arising at the S1 segment (8 cases) were operated either through a pterional or a pretemporal approaches; those from the S2 segment (6 cases) were operated either via the subtemporal or the subtemporal transventricular routes; and that arising from the S3 segment (1 case) was managed through the occipital interhemispheric approach. Among the aneurysms eleven were small, one was large, and four were large or giant. Ten of these aneurysms were surgically clipped, two coagulated, three treated by trapping and in one case the aneurysm was resected and the posterior cerebral artery was reconstructed by a termino-terminal anastomosis. The surgical results were considered good in all cases but one, where the patient died due to clinical complications three months after surgery. It is our belief that the use of this classification can provide the means to best select the most appropriate surgical approach to treat aneurysms arising at the posterior cerebral artery.


Subject(s)
Cerebral Arteries/surgery , Intracranial Aneurysm/surgery , Adolescent , Adult , Female , Humans , Male , Microsurgery , Middle Aged
11.
Acta Neurochir (Wien) ; 138(1): 1-11; discussion 11, 1996.
Article in English | MEDLINE | ID: mdl-8686518

ABSTRACT

Microsurgery of multiple aneurysms is still a controversial subject. In order to avoid the risk of rebleeding and the consequent increase in morbidity in such cases all aneurysms or at least as many aneurysms as possible should be treated in the first operative procedure. To reach that goal aneurysms located on the contralateral side should also be considered for clipping during the first operation. Between 1984 and 1994 a series of 51 patients harboring multiple aneurysms of which 55 aneurysms were located on the contralateral side of the craniotomy were operated at our institution. No mortality or morbidity could be directly ascribed to the aneurysm that was clipped contralaterally. Based on that series we have described the anatomical features, technical aspects and surgical difficulties of approaching bilateral aneurysms through the same craniotomy.


Subject(s)
Aneurysm, Ruptured/surgery , Craniotomy/methods , Dominance, Cerebral/physiology , Intracranial Aneurysm/surgery , Microsurgery/methods , Aneurysm, Ruptured/diagnostic imaging , Aneurysm, Ruptured/pathology , Arteries/pathology , Arteries/surgery , Brain/blood supply , Carotid Artery Diseases/diagnostic imaging , Carotid Artery Diseases/pathology , Carotid Artery Diseases/surgery , Cerebral Angiography , Humans , Intracranial Aneurysm/diagnostic imaging , Intracranial Aneurysm/pathology
12.
Acta Neurochir (Wien) ; 136(3-4): 204-11, 1995.
Article in English | MEDLINE | ID: mdl-8748855

ABSTRACT

A pretemporal approach to the interpeduncular and petroclival regions is described. Through a frontotemporal craniotomy based very low in the middle fossa the temporal lobe is completely exposed. The Sylvian, carotid, chiasmatic, and lamina terminalis cisterns are widely opened. The arachnoid fibers between the uncus and the frontal lobe, as well as those binding the temporal lobe to the tentorial edge and to the oculomotor nerve are also separated. The bridging veins from the temporal pole to the spheno-parietal sinus are usually coagulated and sacrificed allowing for posterior displacement of the temporal lobe. The approach combines the advantages of both the classical pterional and subtemporal approaches providing unhindered exposure of the anterior portion of the tentorial incisura in dealing with vascular and tumoural lesions arising at the sellar, parasellar, and interpeduncular regions, and at the superior aspect of the petroclival region.


Subject(s)
Brain Neoplasms/surgery , Cerebrovascular Disorders/surgery , Craniopharyngioma/surgery , Craniotomy/methods , Microsurgery/methods , Pituitary Neoplasms/surgery , Temporal Lobe/surgery , Basilar Artery/surgery , Diagnostic Imaging , Humans , Intracranial Aneurysm/surgery , Meningeal Neoplasms/surgery , Meningioma/surgery
13.
Am J Surg ; 168(5): 481-4, 1994 Nov.
Article in English | MEDLINE | ID: mdl-7977980

ABSTRACT

The charts of 81 patients who underwent skull base surgery between 1982 and 1993 were reviewed retrospectively. Data relative to demographic aspects, clinical stage, previous treatment, surgical approach, type of reconstruction, histology, extent of disease, complications, and follow-up were analyzed. The craniofacial approach for the anterior fossa was used in 53% of patients, the lateral skull base approach in 12%, and a combination of both in 17. Malignant tumors were diagnosed in 58 patients (72%), and histologically benign tumors in the remaining 23 (28%). Forty-one patients (51%) had skin cancer. There was dural invasion in 31 patients (38%), and 32 (40%) underwent microsurgical flap reconstruction. From the malignant group, 31 (53%) were alive with no evidence of disease (NED), and 6 (10%) were alive with disease. From the benign group, 19 (83%) were alive NED. The most common complications were cerebrospinal-fluid fistula (10%) and flap necrosis (9%). Statistical analyses of survival showed significantly different rates associated with histologic types (P = 0.0002), type of reconstruction (P = 0.0039), and previous treatment (P = 0.0018).


Subject(s)
Skull Neoplasms/surgery , Adolescent , Adult , Aged , Aged, 80 and over , Brain Neoplasms/surgery , Child , Dura Mater/surgery , Female , Humans , Male , Meningeal Neoplasms/surgery , Middle Aged , Retrospective Studies , Skin Neoplasms/surgery , Skull Neoplasms/mortality , Survival Rate
15.
Surg Neurol ; 22(2): 134-40, 1984 Aug.
Article in English | MEDLINE | ID: mdl-6740475

ABSTRACT

To analyze the incidence as well as the natural history of asymptomatic pituitary microadenomas, 450 pituitary glands obtained during routine autopsies were studied. The series consisted of patients of both sexes, without any evidence of pituitary dysfunction, in a broad age range. Thirty-nine tumors were found in 36 pituitary glands, with a peak incidence in the seventh decade of life and an evident predominance in male patients. The medical records and available x-ray films of the skull of these patients with subclinical microadenomas were reviewed for clinical evidence of endocrinopathy and to detect minor radiologic abnormalities of the sella turcica. No significant differences were found in comparing the histologic aspect of these tumors with symptomatic cases. The possibility of these tumors as a preclinical stage of pituitary adenoma or a separate entity is discussed.


Subject(s)
Adenoma/pathology , Pituitary Neoplasms/pathology , Adolescent , Adult , Aged , Child , Child, Preschool , Female , Humans , Infant , Infant, Newborn , Male , Middle Aged
16.
Arq. bras. neurocir ; 3(3): 159-79, 1984.
Article in Portuguese | LILACS | ID: lil-23120

ABSTRACT

Nesta segunda parte do artigo sao feitas consideracoes teoricas e praticas sobre a utilizacao de diureticos, barbituricos, hipotermia e oxigenacao hiperbarica no tratamento da hipertensao intracraniana.Ao final, o importante papel desempenhado pela enfermagem na terapia intensiva da pressao intracraniana elevada e focalizado de maneira eminentemente pratica


Subject(s)
Critical Care , Diuretics , Hyperbaric Oxygenation , Hypothermia , Intracranial Pressure , Nursing Care
17.
Arq. bras. neurocir ; 2(4): 255-60, 1983.
Article in Portuguese | LILACS | ID: lil-19046

ABSTRACT

Os autores relatam caso raro de embolia aerea durante cirurgia da fossa posterior em posicao sentada, no qual a entrada do ar se deu atraves de um dos ferimentos provocados pelos pinos do suporte-fixador de cabeca de Gardner. Sao discutidos os cuidados no preparo dos pacientes para cirurgia em posicao sentada. Sao analisados os 5 casos semelhantes encontrados na literatura


Subject(s)
Middle Aged , Humans , Female , Embolism, Air , Intraoperative Complications
18.
Arq. bras. neurocir ; 2(2): 83-100, 1983.
Article in Portuguese | LILACS | ID: lil-14631

ABSTRACT

Os autores fazem uma revisao sobre os diversos meios, modernamente utilizados, de terapeutica da hipertensao intracraniana.Nesta primeira parte do artigo, a hiperventilacao, a drenagem liquorica ventricular e o uso de corticosteroides sao analisados. Enfase e dada a valiosa contribuicao da monitorizacao continua da pressao intracraniana no controle e tratamento daquele estado patologico


Subject(s)
Humans , Drainage , Hyperventilation , Pseudotumor Cerebri , Adrenal Cortex Hormones , Monitoring, Physiologic
19.
Arq Neuropsiquiatr ; 38(1): 18-23, 1980 Mar.
Article in Portuguese | MEDLINE | ID: mdl-7406751

ABSTRACT

The authors present a critical analysis of the various methods of experimental production of aneurysms and report their own method in which saccular aneurysms were produced at the bifurcation of the common carotid artery in dogs with vein patch grafts. The objective point of this study was the creation of an experimental model to evaluate the efficacy of a therapeutic procedure. These aneurysms have a low incidence of thrombosis and a tendency to enlarge and to become spherical. They closely simulate the saccular aneurysms developing spontaneously in the cerebral arteries of man, and as such are useful models for experimental purposes.


Subject(s)
Carotid Arteries/surgery , Intracranial Aneurysm/surgery , Animals , Arteriovenous Shunt, Surgical , Disease Models, Animal , Dogs , Intracranial Aneurysm/etiology , Intracranial Aneurysm/pathology
20.
Arq Neuropsiquiatr ; 38(1): 24-32, 1980 Mar.
Article in Portuguese | MEDLINE | ID: mdl-7406752

ABSTRACT

Studies were performed on adult mongrel dogs to evaluate the possibility of occluding saccular aneurysms with an intravascular injection of the tissue adhesive Bucrylat (isobutyl-2-cyanoacrylate). Fourteen surgically constructed carotid aneurysms were occluded by the injection of Bucrylat through a fluoroscopically positioned intra-arterial catheter. Angiography performed immediately before and after injection and up to 1 month following treatment revealed progressive and persistent occlusion of the aneurysms. The specimens examined histologically 1 month after the injection showed an endothelialized fibrous tissue bridge crossing the neck of the aneurysm what appear to indicate a permanent occlusion of the structures treated. A similar approach to treat intracranial aneurysms will depend on advances in the field of selective intracranial catheterization that will permit safe and accurate catheterization of the aneurysm sac.


Subject(s)
Bucrylate/administration & dosage , Carotid Arteries , Cyanoacrylates/administration & dosage , Embolization, Therapeutic/methods , Intracranial Aneurysm/therapy , Animals , Bucrylate/pharmacology , Catheterization , Dogs , Injections, Intra-Arterial , Intracranial Aneurysm/diagnostic imaging , Intracranial Aneurysm/pathology , Radiography
SELECTION OF CITATIONS
SEARCH DETAIL
...