Identifying Adult Population at Risk for Undiagnosed Diabetes Mellitus in Medan City, Indonesia Targeted on Diabetes Prevention.

Background: Diabetes mellitus is a health problem in Indonesia, where its prevalence rises annually. The condition may negatively impact one's quality of life and lead to significant complications-over 50% of patients with type 2 diabetes mellitus, the most common diabetes type worldwide. To implement diabetic prevention interventions and achieve effective diabetes mellitus control, screening for undiagnosed diabetes mellitus in high-risk populations is essential. Objective: This study aimed to identify people at risk for undiagnosed diabetes mellitus using the Finnish Diabetes Risk Score (FINDRISC) and oral glucose tolerance test (OGTT). Methods: This cross-sectional study was carried out, which involved 300 people in Medan City between the ages of 30-75. The study was conducted between July 14 and October 20, 2020. The Finnish Diabetes Risk Score and anthropometric measurements (weight, height, and waist circumference) were used to evaluate each respondent. Low, medium, and high-risk outcome categories were created. All responders underwent oral glucose tolerance tests, with results classified as normal, prediabetes, or diabetes. The Chi-square test was used to examine the data and identify potential risk variables for diabetes mellitus. Results: Of 300 individuals, 91.7% were female, and 8.3% were male. 33.7% of participants had a low risk of acquiring diabetes, 55.0% had an intermediate risk, and 11.3% had a high risk. 70% of participants who took an oral glucose tolerance test had blood glucose levels that were normal (less than 100 mg/dl), 18.7% had blood glucose levels suggestive of prediabetes (between 100 and 125 mg/dl), and 11.3% had blood glucose levels suggestive of diabetes (126 mg/dl or higher). Ages 54 to 64 years and older, high body mass index and central obesity, a lack of vegetables and fruits in the daily diet, inactivity, uncontrolled hypertension, a history of hyperglycemia, and a family history of diabetes were all linked to a significant increase in the risk of developing diabetes. Most respondents at low risk of developing type 2 diabetes had normal blood sugar levels, while those at high risk of developing type 2 diabetes had high blood glucose levels (p = 0.005). Conclusion: Oral glucose tolerance testing and the FINDRISC questionnaire may be used to identify individuals who are at high risk for developing diabetes and to encourage them to adopt healthy behaviours.

Survivor's experience in fighting breast cancer.

Considering that breast cancer diagnosis affects a woman physically and emotionally, treatment during the therapy phase requires enthusiasm. Therefore, this study aims to explore breast cancer survivors' experiences with treatment. A qualitative methodology was used, while the data were collected with in-depth interviews and analyzed using interpretative phenomenological analysis. The study samples included up to five individuals who met the inclusion criteria of having stage III breast cancer for longer than 5 years without metastases and were obtained using the purposive sampling technique. Two themes emerged from the interview data, namely, the past events and the psychological state of breast cancer patients. There were four subthemes under the overall theme of the events, including risk factors for breast cancer, symptoms, extensive therapy, and preventing metastases. Meanwhile, the psychological state theme contained six sub-themes, including rejection and anger against diagnosis, despair, embracing the disease, self-concept, and stress. Before beginning treatment, patients implicitly expect clinicians to provide them with a thorough explanation of how chemotherapy works. Based on the results, it can be concluded that supporting and empowering breast cancer patients is a struggle for caregivers and healthcare professionals.

Open Clinical Trial of Sambiloto (Andrographis paniculata) Ethanolic Extract Capsules in Treatment of Malaria Patients in Batubara District, Indonesia.

Introduction: Malaria infection is still a public health problem in Indonesia. One of the problems in combating malaria in Indonesia is the limited kind of antimalarial drugs provided by the government. Sambiloto (Andrographis paniculata) extract has been shown to have antimalarial activity in human clinical trials. Aim: To assess the ability of a single A. paniculata ethanolic extract capsule to treat malaria in humans caused by Plasmodium falciparum or P. vivax alone or mixed infections of both. Methods: An open clinical trial was conducted in Batubara District, Sumatra Utara Province, Indonesia, a malaria-endemic area. Sixty-nine malaria patients found in the field were diagnosed microscopically as malaria vivax, malaria falciparum, and mixed infections uncomplicated malaria with 12 years old and above. Previously all patients signed informed consent. All patients have been treated with A. paniculata ethanolic extract capsules 250 mg thrice a day for five days. Parasite density was calculated from D0, D1, D2, D3, D7, D14, and D28. Results: The efficacy of A . paniculata ethanolic extract capsules 250 mg thrice a day for five days against malaria vivax, malaria falciparum, and mixed malaria patients was 94.2%. There are no side effects were found during treatment. Conclusion: A. paniculata ethanolic extract can be used as an alternative antimalarial candidate derived from native Indonesian medicinal plants or as an adjunct in standard treatment for malaria.

The Influence of Nutritional Status and Ventilation on the Incidence of Pulmonary Tuberculosis at Langsa.

BACKGROUND: Pulmonary Tuberculosis is still a global health threat and the cause of the average of 1.3 million deaths each year. AIM: The objective of the research was to analyse the influence of ventilation and nutritional status on the incidence of pulmonary tuberculosis at Langsa, in 2018. METHODS: The population was all pulmonary tuberculosis adult patients at Langsa, in 2018, with AFB+ of 315 people, and the samples were 116 patients in the case group and 116 patients in the control group. The data were analysed by using logistic regression with simple logistic regression test and multiple logistic regression tests. RESULTS: The result of multiple logistic regression tests showed that there was the influence of nutritional status (p ≤ 0.001; OR = 2.645 (95% CI 1.494-4.683) and ventilation (p ≤ 0.044; OR = 1.816 (95% CI 1.015-3.250) on the incidence of pulmonary tuberculosis. CONCLUSION: To break off the chain of pulmonary tuberculosis contagion, it is necessary to increase people's awareness of the importance of healthy life behaviour and healthful home by providing health counselling about the requirement for good nutritional status and ventilation.

The Relationship of Physical Activity and Obesity with the Incidence of Hypertension in Adults Aged 26-45 Years in Medan.

BACKGROUND: The incidence rate of hypertension is increasing in Indonesia concerning unhealthy behaviours such as unhealthy physical activity and eating pattern which trigger obesity. In Indonesia, the prevalence of hypertension in > 18-year-old people was 34.1% in 2018. AIM: The objective of the research was to find out the relationship between physical activity and obesity with the incidence of hypertension in adults (26-45 years old) in Medan. METHODS: The research was done in Medan, using a case-control study design. The samples were 150 hypertension patients, taken by using proportional allocation: 75 of them were in the case group and the other 75 of them were in the control group. The data were gathered by conducting interviews, measurement, and questionnaires and analysed by using simple logistic regression test. RESULTS: The result of the research showed that there was significant relationship of physical activity (p = 0.000; OR = 3.6; 95% CI, 1.802-7.270) and obesity (p = 0.000; OR = 4; 95% CI, 2.030-7.900) with the incidence of hypertension in 26-45-year-old respondents. CONCLUSION: Make a habit of a healthy lifestyle in their daily life by doing physical activity regularly and good eating pattern to forestall hypertension.