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1.
J Infect Dis ; 204(11): 1772-8, 2011 Dec 01.
Article in English | MEDLINE | ID: mdl-21998472

ABSTRACT

One approach to investigate if human genetic variation influences the selection of Plasmodium falciparum drug resistance is to compare the frequency of resistant infections among human populations differing in their genetic background and living in the same epidemiological context. A further complementary approach consists in comparing drug resistance among subjects differing for genes involved in drug metabolism. Here we report, from malariological surveys performed in Burkina Faso, that the prevalence of P. falciparum chloroquine-resistant infections (pfcrt 76T and/or pfmdr1 86Y alleles) differs among sympatric ethnic groups, being higher in the Mossi and Rimaibé groups than in the Fulani group (odds ratio [OR], 2.24; 95% confidence interval [CI], 1.27-3.92; P = .007). The association analysis revealed that the human CYP2C8*2 variant, known to determine a poor drug metabolizer phenotype, was associated with P. falciparum chloroquine-resistant infections (OR, 1.66; 95% CI, 1.13-2.43; P = .008). This variant is more frequent in the Mossi-Rimaibé group (23.7% ± 1.4%) than in the Fulani group (9.9% ± 2.5%; P = .0003). This study provides an example of how host genetic variation may influence the selection dynamics of a pathogen's drug resistance.


Subject(s)
Aryl Hydrocarbon Hydroxylases/genetics , Black People/genetics , Drug Resistance/genetics , Malaria, Falciparum/genetics , Plasmodium falciparum/drug effects , Adolescent , Adult , Alleles , Antimalarials/pharmacology , Burkina Faso/epidemiology , Child , Chloroquine/pharmacology , Cross-Sectional Studies , Cytochrome P-450 CYP2C8 , Genetic Variation , Genotype , Humans , Malaria, Falciparum/ethnology , Malaria, Falciparum/parasitology , Membrane Transport Proteins/genetics , Middle Aged , Multidrug Resistance-Associated Proteins/genetics , Plasmodium falciparum/genetics , Prevalence , Protozoan Proteins/genetics , Young Adult
2.
Hum Immunol ; 70(11): 903-9, 2009 Nov.
Article in English | MEDLINE | ID: mdl-19664674

ABSTRACT

The Fulani of west Africa have been shown to be less susceptible to malaria and to mount a stronger immune response to malaria than sympatric ethnic groups. The analysis of HLA diversity is useful for the assessment of the genetic distance between the Fulani and sympatric populations, which represents the necessary theoretical background for the investigation of genetic determinants of susceptibility to malaria. We assessed the polymorphism of HLA-DRB1 and -DQB1 loci and analyzed the distribution of alleles/haplotypes in Fulani, Mossi, and Rimaibé from Burkina Faso. We then investigated the genetic relationship of these three ethnic groups with other sub-Saharan African populations as well as with Europeans. We confirmed that the Fulani from Burkina Faso are genetically distinct from sympatric Mossi and Rimaibé. Furthermore the Fulani from Burkina Faso are close to those from The Gambia and, intriguingly, share the distribution of specific alleles with east African populations (Amhara and Oromo). It is noteworthy that the HLA-DRB1*04 and -DQB1*02 alleles, which are implicated in the development of several autoimmune diseases, are present at high frequency in the Fulani, suggesting their potential involvement in the enhanced immune reactivity observed in this population.


Subject(s)
Genetic Loci , Genetics, Population , HLA-DQ Antigens/genetics , HLA-DR Antigens/genetics , Membrane Glycoproteins/genetics , Adolescent , Adult , Africa South of the Sahara , Africa, Western , Aged , Child , Europe , HLA-DQ Antigens/immunology , HLA-DQ beta-Chains , HLA-DR Antigens/immunology , HLA-DRB1 Chains , Humans , Membrane Glycoproteins/immunology , Middle Aged , Young Adult
3.
Am J Trop Med Hyg ; 71(2): 173-8, 2004 Aug.
Article in English | MEDLINE | ID: mdl-15306706

ABSTRACT

We have characterized Plasmodium falciparum genotypes among the Mossi and Fulani sympatric ethnic groups in villages in Burkina Faso during the rainy season. Differences in clinical malaria presentation and in immune responses to malaria occur between the two groups. Asexual parasite rate, density, and gametocyte rate were higher among the Mossi than the Fulani. There was no difference in frequencies of alleles of the P. falciparum merozoite surface protein 1 (msp-1), msp-2, and glutamate-rich protein (glurp) genes among the parasites in each group. However, there were significant differences in the mean number of P. falciparum clones in the two populations, with there being more in the Mossi than in the Fulani. This effect was especially marked in older children. These differences can most probably be attributed to genetic differences in immune responsiveness to malaria between the two ethnic groups.


Subject(s)
Genetic Variation , Malaria, Falciparum/ethnology , Malaria, Falciparum/genetics , Plasmodium falciparum/classification , Plasmodium falciparum/genetics , Animals , Anopheles/parasitology , Antigens, Protozoan/genetics , Black People , Burkina Faso/epidemiology , Burkina Faso/ethnology , Child , Child, Preschool , Ethnicity , Genetic Predisposition to Disease , Genotype , Humans , Malaria, Falciparum/immunology , Malaria, Falciparum/parasitology , Merozoite Surface Protein 1/genetics , Plasmodium falciparum/isolation & purification , Protozoan Proteins/genetics , White People
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