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1.
J Clin Tuberc Other Mycobact Dis ; 18: 100140, 2020 Feb.
Article in English | MEDLINE | ID: mdl-31909226

ABSTRACT

BACKGROUND: Smear microscopy is the mainstay for diagnosis of Tuberculosis (TB) in Ethiopia. This technique; however, is insensitive to detect Mycobacteria from most clinical specimens. Currently, light emitting diode (LED) fluorescence microscope is advocated to be used in high Tuberculosis (TB) burden settings by World Health Organization (WHO). However, the utility of this method is not evaluated for bleach treated sputum samples in Ethiopia. OBJECTIVE: The objective of the study is to evaluate the diagnostic importance of Auramine O (AO) staining in direct and concentrated sputum against conventional Zehil-Neelsen (ZN) and culture from the sputum samples of suspected pulmonary tuberculosis patients. METHODS: A cross-sectional study was conducted on 346 adult new pulmonary TB suspected patients at St. Peter's Specialized Hospital, Addis Ababa, Ethiopia. Three sputum samples (spot-morning-spot) were collected in sterile cups for direct Zehil-Neelsen and AO staining. Morning sputum samples were used for Mycobacterial culture on Mycobacterial Growth Indicator Tube (MGIT) 960. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) were evaluated against the gold standard culture method. Data were analyzed using STATA version 13.0. All statistical tests were considered as statistically significant if the two sided P-value was < 0.05. RESULTS: Bleach treated sputum samples with AO staining yielded more cases as compared to direct ZN and direct AO by 6.3% and 11.5%, respectively. The sensitivity of concentrated AO and direct AO were remarkably high as compared to conventional ZN (71.8% vs. 44.5% and 62.7% vs. 44.5%). The concentrated sputum with staining of AO had a high rate (18.6%) of detecting scanty graded smears as compared to conventional ZN method. CONCLUSIONS: Our findings indicated that the concentrated sputum with AO staining yielded high rate of sensitivity (71.8%) as compared to the conventional ZN method (44.5%). Moreover, the concentrated sputum with AO staining had superior ability in detecting scanty graded smears compared to the conventional ZN method. Therefore, it is recommended to utilize AO staining with LED microscopy for better diagnosis of Acid Fast Bacilli (AFB) from TB suspected cases and patients with pauci-bacillary TB in Ethiopia.

2.
Int J Infect Dis ; 77: 74-81, 2018 Dec.
Article in English | MEDLINE | ID: mdl-30336266

ABSTRACT

BACKGROUND: Globally, HIV and tuberculosis (TB) are a leading cause of death if they occur as co-morbidities in affected individuals. The aim of this study was to evaluate the collaboration between TB and HIV control activities by determining the co-morbidity rate in Oromia Region, Ethiopia, during the period 2009-2015. METHODS: A retrospective health facility-based study was conducted. Data were collected from health facilities implementing the directly observed treatment short-course (DOTS) strategy in the region. A structured World Health Organization (WHO) reporting format was used as the data collection tool. Pre-antiretroviral therapy (ART)/voluntary counselling and testing for HIV (VCT) and TB unit registers were considered as the data sources. Data were collected quarterly and analyzed using IBM SPSS Statistics version 20. The odds ratio was used to assess statistical differences among variables. RESULTS: A total of 115268 TB patients were counselled and tested for HIV during the study period. Among the patients tested, 60086 (52.1%) were male, of whom 13680 (11.8%) were found to have an HIV infection. Among TB patients who were co-infected with HIV, there were slightly higher odds of HIV infection in females than in males (odds ratio 1.13, 95% confidence interval 1.09-1.17). Between 2009 and 2013, about 56% of TB and HIV co-morbid patients were put on co-trimoxazole preventive therapy (CPT) and 35% on ART. HIV infection occurred predominantly within the age group of 25-34 years (31%). On the other hand, 197152 HIV-infected patients were screened for TB symptoms and 8.4% were found to have active TB. The odds of having TB among males who were initially infected with HIV were higher as compared to females (odds ratio 1.31, 95% confidence interval 1.27-1.37). CONCLUSIONS: The prevalence of TB and HIV co-morbidity was 11.8% at TB clinics in the region. Low proportions of co-infected patients were put on CPT and ART. Therefore, it is essential to strengthen the WHO recommended TB and HIV collaborative activities in the region to reduce the burden of co-morbidity and mortality.


Subject(s)
Communicable Disease Control , HIV Infections/epidemiology , Outcome and Process Assessment, Health Care , Tuberculosis/epidemiology , Adolescent , Adult , Anti-Retroviral Agents/therapeutic use , Child , Child, Preschool , Comorbidity , Ethiopia/epidemiology , Female , Follow-Up Studies , HIV Infections/drug therapy , HIV Infections/prevention & control , Humans , Infant , Male , Middle Aged , Prevalence , Retrospective Studies , Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use , Tuberculosis/drug therapy , Tuberculosis/prevention & control , World Health Organization , Young Adult
3.
PLoS One ; 13(6): e0198947, 2018.
Article in English | MEDLINE | ID: mdl-29924828

ABSTRACT

OBJECTIVES: Quality of tuberculosis (TB) microscopy diagnosis is not a guarantee despite implementation of External Quality Assurance (EQA) service in all laboratories of health facilities. Hence, we aimed at evaluating the technical quality and the findings of sputum smear microscopy for acid fast bacilli (AFB) at health centers in Hararge Zone, Oromia Region, Ethiopia. METHODS: A cross-sectional study was carried out between July 8, 2014 and July 7, 2015.A pre-tested structured questionnaire was used to collect data. Lot Quality Assurance Sampling (LQAS) method was put into practice for collecting all necessary sample slides. Data were analyzed by using SPSS (Statistical Package for Social Sciences) version 20 software. P-value < 0.05 was considered as statistically significant. RESULTS: Of the total55 health center laboratories which had been assessed during the study period, 20 (36.4%) had major technical errors; 13 (23.6%) had 15 false negative results and 17 (30.9%) had 22 false positive results. Moreover, poor specimen quality, smear size, smear thickness, staining and evenness were indicated in 40 (72.7%), 39 (70.9%), 37 (67.3%), 27(49.1%) and 37 (67.3%) of the collected samples, respectively. False negative AFB findings were significantly associated with lack of Internal Quality Control (IQC) measures (AOR (Adjusted Odds Ratio): 2.90 (95% CI (Confidence Interval): 1.25,6.75) and poor staining procedures (AOR: 2.16(95% CI: 1.01, 5.11). CONCLUSIONS: The qualities of AFB smear microscopy reading and smearing were low in most of the laboratories of the health centers. Therefore, it is essential to strength EQA program through building the capacity of laboratory professionals.


Subject(s)
Bacteriological Techniques/methods , Laboratories/statistics & numerical data , Mycobacterium tuberculosis/isolation & purification , Quality Control , Sputum/microbiology , Tuberculosis/diagnosis , Confidence Intervals , Cross-Sectional Studies , Ethiopia/epidemiology , False Negative Reactions , False Positive Reactions , Humans , Laboratories/standards , Microscopy/methods , Odds Ratio , Quality Assurance, Health Care/organization & administration , Quality Improvement/organization & administration , Specimen Handling/methods , Tuberculosis/epidemiology , Tuberculosis/microbiology
4.
Front Med (Lausanne) ; 5: 38, 2018.
Article in English | MEDLINE | ID: mdl-29516002

ABSTRACT

BACKGROUND: Directly Observed Treatment Short-course (DOTS) has been one of the major strategies to combat the epidemic of tuberculosis (TB) globally. This study aimed to evaluate TB treatment outcomes between September 2004 and July 2014 under the DOTS program at one of the largest public hospitals in Ethiopia. METHODS: A retrospective data of TB patients registered at Asella Teaching Hospital between September 2004 and July 2014 were obtained from hospital registry. Treatment outcomes and types of TB cases were categorized according to the national TB control program guideline. Binomial and multinomial logistic regression models were used to analyze the association between treatment outcomes and potential predictor variables. RESULTS: A total of 1,755 TB patients' records were included in the study. Of these, 945 (53.8%) were male, 480 (27.4%) smear-positive TB, 287 (16.4%) HIV positive, and 1,549 (88.3%) new cases. Among 480 smear-positive pulmonary TB cases, 377 (78.5%) patients were cured, 21 (4.40) completed the treatment, 35 (7.3%) transferred out, 19 (4.0%) died, 24 (5.0%) defaulted, and 4 (0.8%) failure. Overall, 398 (82.9%) smear-positive pulmonary TB patients were successfully treated. For smear-negative TB (n = 641) and extrapulmonary TB cases (n = 634), 1,036 (81.3%) completed the treatment and demonstrated favorable response. Taking all TB types into account, 1,434 (81.7%) were considered as successfully treated. In the multivariate binary logistic model, patients in older age group (AOR = 0.386, 95% CI: 0.250-0.596) and retreatment cases (AOR = 0.422, 95% CI: 0.226-0.790) were less likely to be successfully treated compared to younger and new cases, respectively. In multinomial logistic regression, age increment by 1 year increased the risk of death and default of TB patients by 0.05 (adjusted ß = 0.05; 95% CI: 0.03, 0.06) and 0.02 (adjusted ß = 0.02; 95% CI: 0.01, 0.04). The odds of TB patients who died during treatment were higher among HIV-infected TB patients (adjusted ß = 2.65; 95% CI: 1.28, 5.50). CONCLUSION: The treatment success rate of TB patients was low as compared to the national target. TB control needs to be strengthened for the enhancement of treatment outcome.

5.
Public Health ; 152: 1-8, 2017 Nov.
Article in English | MEDLINE | ID: mdl-28715656

ABSTRACT

OBJECTIVES: Adequate nutrition is an important factor to determine the health and well-being of women, children and society as a whole. Although various nutritional policies were formulated and aimed at reducing malnutrition at the global level, the magnitude of malnutrition (body mass index [BMI] <18.5 kg/m2) among women remained between 10% and 40% in most low- and middle-income countries. We aimed to determine the prevalence of malnutrition and to identify the associated risk factors among women of reproductive age. STUDY DESIGN: A cross-sectional study was conducted in Ziway Dugda district in Ethiopia among 430 women of reproductive age between September 20 and November 21, 2015. METHODS: A systematic sampling method was used to select the study participants. Descriptive statistics and logistic regression were used to determine the prevalence of malnutrition and to identify associated independent risk factors such as women's age, housing conditions, drinking water sources, habits of hand washing, dietary intake and food insecurity. RESULTS: The mean values of weight, height and BMI of the study participants were 51 kg, 157 cm and 18.1 kg/m2, respectively. Prevalence of malnutrition (BMI <18.5 kg/m2) among women of reproductive age was found to be 48.6%. Being in the age group of 26-35 years (adjusted odds ratio [AOR] = 0.50, 95% confidence interval [CI] = 0.26-0.84), thatched housing conditions (AOR = 1.83, 95% CI = 1.16-2.89), unprotected sources of drinking water (AOR = 1.65, 95% CI = 1.06-2.57), lack of habit of hand wash after using the toilet (AOR = 1.62, 95% CI = 1.06-2.47), consumption of fish (AOR = 2.12, 95% CI = 1.12-3.99), consumption of dairy products (AOR = 2.40, 95% CI = 1.42-4.03) and food insecurity (AOR = 2.44, 95% CI = 1.50-3.95) were considered as independent predictors of risk for having malnutrition among women of the same age group compared to women from food secured households. CONCLUSIONS: A high prevalence of malnutrition (48.6%) was observed among women of reproductive age. Although nutrient-rich foods were available, their consumption appears insufficient. Hence, it is strongly recommended to have behavioural change communication for enhancing adequate intake of a diversified diet and to promote environmental and hygienic conditions of women through improving their socio-economic status.


Subject(s)
Malnutrition/epidemiology , Adolescent , Adult , Cross-Sectional Studies , Ethiopia/epidemiology , Female , Humans , Middle Aged , Prevalence , Risk Factors , Young Adult
6.
BMC Public Health ; 17(1): 121, 2017 01 25.
Article in English | MEDLINE | ID: mdl-28122536

ABSTRACT

BACKGROUND: HIV/AIDS is a major public health problem in Ethiopia. University students are often a young and sexually active group that is at risk of acquiring and transmitting HIV. We assessed risky HIV sexual behaviors and utilization of voluntary counseling and testing services among undergraduate students at Addis Ababa Science and Technology University, Ethiopia. METHODS: A cross-sectional study was conducted between May and June, 2013. Standardized semi-structured self-administered questionnaire was used to collect data. Simple random sampling technique was use to select departments from each school. All students in the selected departments were the study participants. Data were entered into EPI-Info and analyzed using SPPS statistical packages. P-value < 0.05 was considered as statistically significant. RESULTS: Of the total 602 students selected, an overall response rate of 557 (92.6%) were registered. Among the participants 361 (60%) were males. The student ages' were ranged from 17 up to 25 years with mean age of 20.3 ± 1.6. Around 385 (64%) of them were in the age group of 17 up to 20 years. Among the study participants, 161 (26.8%) had sexual contact and the mean age of first sexual encounter was 17.4 (SD =2.3) years. About 443 (76%) of students knew that condoms can prevent Sexually Transmitted Infections (STIs). Among sexually active students, 74 (46%) had not used condom during first time sex. Among those responded, 488 (83.4%) had heard information about VCT; however, 52% had not ever used VCT service. The overall mean score of knowledge and attitude of students towards risk perception on HIV was around 66% and 57%, respectively. Students who enrolled in health science departments had almost three time more knowledge [AOR(95%CI) = 2.83 (1.67, 4.80)] and two and half times more favorable [AOR (95% CI) = 2.55 (1.60, 4.06)] attitudes towards HIV risk reduction strategies than students in non-health related departments. CONCLUSIONS: Some students were engaged in risky sexual behaviour even though they had heard about HIV/AIDS. The perception of risk for acquisition of HIV infection and utilization of VCT were low. HIV prevention and control strategies including education in the areas of HIV/AIDS as part of university programs curriculum, specially non-health students, and strengthening health institutions to provide youth-friendly VCT services for HIV with "know your HIV status" campaigns are strongly recommended.


Subject(s)
Counseling/statistics & numerical data , HIV Infections/psychology , Risk-Taking , Sexual Behavior/psychology , Students/psychology , Adolescent , Condoms/statistics & numerical data , Cross-Sectional Studies , Ethiopia , Female , HIV Infections/prevention & control , Humans , Male , Perception , Schools , Sexually Transmitted Diseases/prevention & control , Surveys and Questionnaires , Universities , Young Adult
7.
Int J Mycobacteriol ; 5(2): 164-9, 2016 06.
Article in English | MEDLINE | ID: mdl-27242227

ABSTRACT

OBJECTIVE/BACKGROUND: The World Health Organization (WHO) declared tuberculosis (TB) as a global public health emergency and recommended directly observed treatment, short-course (DOTS) as a standard strategy to control the disease. In Ethiopia the strategy was started in 1992 as a pilot in the Arsi and Bale zone, Oromia Region. The DOTS strategy has been subsequently scaled up in the country and implemented at a national level reaching better coverage, although there are recognizable variations from region to region and district to district. The aim of this study was to assess the impact of the DOTS strategy on smear-positive pulmonary TB case findings and their treatment outcomes in the Afar Regional State, Ethiopia, from 2003 to 2012 and from 2002 to 2011, respectively. METHODS: A health facility-based retrospective study was conducted. Data were collected and reported on a quarterly basis using the WHO reporting format for TB case findings and their treatment outcomes from all DOTS-implementing health facilities in all zones of the region to the Federal Ministry of Health. RESULTS: A total of 34,894 of TB cases had been registered in the period from 2003 to 2012. Out of these, 11,595 (33.2%) were smear-positive pulmonary TB, 13,859 (39.7%) smear-negative pulmonary TB, and 9838 (28.2%) extrapulmonary TB. The case detection rate (CDR) of smear-positive pulmonary TB had increased from 18.3% to 37.2%, with the average value being 32% (standard deviation=6.8) from the total TB cases to its peak of 39% in 2008. The treatment success rate (TSR) had an average value of 86.2% from 2002 to 2011 with its peak value being 96.5% in 2007. Moreover, the average values of treatment defaulter and treatment failure rate were 2.9% and 2.7%, respectively. CONCLUSION: The implementation for the DOTS strategy in the area improved the CDR of smear-positive TB, although it is unacceptably lower than the recommended WHO target of 70%. Additionally, the WHO target of 85% for TSR had already been achieved in the region. However, continued efforts should be in place to increase the CDR and maintain the high TSR registered.


Subject(s)
Antitubercular Agents/therapeutic use , Tuberculosis, Pulmonary/diagnosis , Tuberculosis, Pulmonary/drug therapy , Adolescent , Adult , Aged , Child , Child, Preschool , Ethiopia/epidemiology , Female , Humans , Infant , Middle Aged , Mycobacterium tuberculosis/growth & development , Mycobacterium tuberculosis/isolation & purification , Retrospective Studies , Treatment Failure , Treatment Outcome , Tuberculosis, Pulmonary/epidemiology , Tuberculosis, Pulmonary/microbiology , Young Adult
8.
Int J Mycobacteriol ; 5 Suppl 1: S117-S118, 2016 Dec.
Article in English | MEDLINE | ID: mdl-28043497

ABSTRACT

BACKGROUND: World Health Organization (WHO) declared tuberculosis (TB) as a global public health emergency and recommended DOTS as a standard strategy for controlling the disease. TB is one of the major causes of infectious diseases in the world, and 25% of all avoidable deaths in developing countries. About a third of the world's population is estimated to be infected with tubercle bacilli, and hence at risk of developing active disease. The objective of the study was, therefore, to evaluate the impact of DOTS strategy on smear-positive pulmonary tuberculosis case finding and their treatment outcomes in Gambella Regional State, Ethiopia. METHODS: A retrospective health facility-based descriptive study was employed. Quarterly data were collected by using WHO structured reporting format for TB case finding and treatment outcome from all DOTS implementing health facilities in the region. RESULTS: A total of 10,024 TB cases (all forms) were registered and reported between the periods from 2003 up to 2012. Out of these, 4100 (40.9%) were smear-positive pulmonary TB, 3164 (31.6%) were smear-negative pulmonary TB and 2760 (27.5%) had extra-pulmonary TB. An average case detection rate (CDR)1 of 40.9% (SD=0.1) and treatment success rate (TSR)2 of 55.7% (SD=0.28) for smear-positive pulmonary TB including other forms of TB were reported for the specified years period. Additionally, the average mean values of treatment defaulter and treatment failure rates were 4.2% and 0.3%, respectively. CONCLUSIONS: The recommended TSR set by WHO was achieved as it was already been fulfilled more than 85% from 2009 up to 2011 in the region and the reported CDR was far below (40.9%) for smear-positive pulmonary TB including other forms of TB from the target. Therefore, extensive efforts should be established to maintain the achieved TSR and to increase the low level of CDR for all forms of TB cases through implementing alternative case finding strategies.

9.
BMC Res Notes ; 8: 357, 2015 Aug 19.
Article in English | MEDLINE | ID: mdl-26285700

ABSTRACT

BACKGROUND: A third of the world population is infected with tuberculosis (TB) bacilli. TB accounts for 25% of all avoidable deaths in developing countries. The objective of the study was to assess impact of directly observed treatment short-course (DOTS) strategy on new tuberculosis case finding and treatment outcomes in Somali Regional State, Ethiopia from 2003 up to 2012 and from 2004 up to 2013, respectively. METHODS: A health facility based retrospective study was employed. Quarterly reports were collected using World Health Organization (WHO) reporting format for TB case finding and treatment outcome from all zones in the region to the Federal Ministry of Health. RESULTS: A total of 31, 198 all types of new TB cases were registered and reported during the period from 2003 up to 2012, in the region. Out of these, smear positive pulmonary TB cases were 12,466 (40%), and 10,537 (33.8%) and 8195 (26.2%) for smear negative pulmonary TB and extra-pulmonary TB cases, respectively. An average case detection rate (CDR) of 19.1% (SD 3.6) and treatment success rate (TSR) of 85.5% (SD 5.0) for smear positive pulmonary TB were reported for the specified years period. For the overall study period, trend chi-squire analysis for CDR was X(2) = 2.1; P > 0.05 and X(2) = 5.64; P < 0.05 for TSR. CONCLUSIONS: The recommended TSR set by WHO was achieved (85.5%) and the CDR reported was far below (19.1%) from the recommended target. Extensive efforts should be established to maintain the achieved TSR and to increase the low CDR for the smear positive pulmonary TB cases through implementing alternative case finding strategies.


Subject(s)
Antitubercular Agents/therapeutic use , Tuberculosis, Pulmonary/drug therapy , Adolescent , Adult , Child , Child, Preschool , Developing Countries , Drug Administration Schedule , Ethiopia/epidemiology , Female , Humans , Infant , Infant, Newborn , Male , Microscopy , Mycobacterium tuberculosis/drug effects , Mycobacterium tuberculosis/isolation & purification , Retrospective Studies , Treatment Outcome , Tuberculosis, Pulmonary/diagnosis , Tuberculosis, Pulmonary/epidemiology , Tuberculosis, Pulmonary/microbiology
10.
BMC Res Notes ; 7: 518, 2014 Aug 12.
Article in English | MEDLINE | ID: mdl-25112147

ABSTRACT

BACKGROUND: Human immunodeficiency virus (HIV) epidemic among youth is largely ignored and remains invisible to both young people themselves and to the society as a whole. Thus, the aim of the study was to assess the extent of perception risk of HIV and utilization of voluntary counseling and testing (VCT) service among high school students at Debre-berhan Town, Amhara Regional State, Ethiopia. METHODS: A cross-sectional study was carried out from November 2010 up to January 2011 among secondary school students at Debre-berhan Town. Perception risk and VCT use were considered as dependant variables. A stratified random sampling technique was used to recruit study participants by taking schools as strata. Semi-structured self-administered questionnaire was used to collect the necessary data. Data was entered and analyzed using SPSS version 17.0. P-value < 0.05 was considered as statistically significant. RESULTS: A total of 339 students were consented to participate in the study and the response rate was 96.3%. The student ages' were ranged from 15 up to 24 years. Among the study participants, 30 (8.8%) had sexual contact and the mean age of first sexual encounter was 16.4 (SD =2.05) years. Of sexually active students, 12 (40%) had sex with different persons within the last 6 months, 13 (43.3%) had ever used condom and 15 (50%) had used VCT service. There was no statistically significant association between risk perception towards HIV infection and ever use of VCT service (AOR (95% CI) = 1.0(0.30, 4.02). CONCLUSIONS: Some students were engaged in risky sexual behavior even though they had heard about HIV/AIDS. The perception of risk for acquisition of HIV infection and utilization of VCT were low. Thus, education on topic of HIV/AIDS through integrating as part of school curriculum and encouraging the existing health institutions to provide youth-friendly sexual counseling services including VCT for HIV are strongly recommended.


Subject(s)
Counseling/statistics & numerical data , HIV Infections/diagnosis , HIV Infections/psychology , Health Knowledge, Attitudes, Practice , Schools , Students/psychology , Voluntary Programs , Adolescent , Cross-Sectional Studies , Demography , Ethiopia , Female , HIV Infections/transmission , Humans , Male , Risk Factors , Sexual Behavior/psychology , Young Adult
11.
BMC Res Notes ; 7: 44, 2014 Jan 20.
Article in English | MEDLINE | ID: mdl-24444379

ABSTRACT

BACKGROUND: Tuberculosis is still the leading cause of illness in the world which accounted for 2.5% of the global burden of disease, and 25% of all avoidable deaths in developing countries. The aim of study was to assess impact of DOTS strategy on tuberculosis case finding and treatment outcome in Gambella Regional State, Ethiopia from 2003 up to 2012 and from 2002 up to 2011, respectively. METHODS: Health facility-based retrospective study was conducted. Data were collected and reported in quarterly basis using WHO reporting format for TB case finding and treatment outcome from all DOTS implementing health facilities in all zones of the region to Federal Ministry of Health. RESULTS: A total of 10024 all form of TB cases had been registered between the periods from 2003 up to 2012. Of them, 4100 (40.9%) were smear-positive pulmonary TB, 3164 (31.6%) were smear-negative pulmonary TB and 2760(27.5%) had extra-pulmonary TB. Case detection rate of smear-positive pulmonary TB had increased from 31.7% to 46.5% from the total TB cases and treatment success rate increased from 13% to 92% with average mean value of being 40.9% (SD = 0.1) and 55.7% (SD = 0.28), respectively for the specified year periods. Moreover, the average values of treatment defaulter and treatment failure rates were 4.2% and 0.3%, respectively. CONCLUSION: It is possible to achieve the recommended WHO target which is 70% of CDR for smear-positive pulmonary TB, and 85% of TSR as it was already been fulfilled the targets for treatments more than 85% from 2009 up to 2011 in the region. However, it requires strong efforts to enhance case detection rate of 40.9% for smear-positive pulmonary TB through implementing alternative case finding strategies.


Subject(s)
Antitubercular Agents/therapeutic use , Tuberculosis/drug therapy , Antitubercular Agents/administration & dosage , Developing Countries , Ethiopia/epidemiology , Female , Humans , Male , Mycobacterium tuberculosis/isolation & purification , Retrospective Studies , Sputum/microbiology , Treatment Outcome , Tuberculosis/epidemiology , Tuberculosis/microbiology
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