[Dynamics of osteogenesis after inoculation of autogenic mesenchymal stem cells of adipose tissue].

Experiment was conducted on 40 rats of Wister line. On the artificially reproduced experimental model autogenic mesenchimal stem cells (MSC) of adipose tissue were inoculated in space between bone autograph of tibia and mandible. MSC wasn't inoculated in the comparison group. Formation of a new bone substance in space between an autograph and mandible bone was observed. It was clear that after 120 days (180 days), there was a statistically significant decline of the area occupied by an immature fibroreticular bone. Described phenomenon, presumably, could be explained as a result of decline of the number of active cells in the population of inoculated MSC according to phenomenon of limited number divisions of cells on telomeres, described by Hayflick L. and Moorhead P.S.

[Influence of transplantation of autogenic mezenhymal stem cells from the fatty tissues on osseogenic process (experimental research)].

In experiments on 48 rats of line Wistar, divided at 2 groups (first--basic group and 2-d group--group of comparison) through the use of morphological method was researched influence of mesenchymal stem cells (MSC) inoculated in the area of autogenic bone graft from tibia fixed at the surface of the jaw. The animals of group of comparison didn't get MSC. Time frames of watching: 21, 60, 120 and 180 days, 6 rats on the point of experiment in either of the two of the group. Data of this research had shown the intensification of bone formation process in the basic group of experiment under the action of the inoculation of autogenic MSC from adipose tissue, and as consequence of it, in eventual, merge of bone formations in a single entity.