ABSTRACT
Herein we report a practical synthetic route to the lasso peptide lassomycin () and C-terminal variant lassomycin-amide (). The biological evaluation of peptides and against Mycobacterium tuberculosis revealed that neither had any activity against this bacterium. This lack of biological activity has led us to propose that naturally occurring lassomycin may actually exhibit a standard lasso peptide threaded conformation rather than the previously reported unthreaded structure.
Subject(s)
Amide Synthases/chemistry , Peptides, Cyclic/chemistry , Peptides, Cyclic/chemical synthesis , Amino Acid Sequence , Chemistry Techniques, Synthetic , Molecular Conformation , Protein ConformationABSTRACT
Growth of China s infants and children has improved since the introduction of economic reforms. After 1979, secular increases in both weight and length have been observed. In certain industrial centers, infant lengths have caught up to international standards. Overall prevalence of underweight and stunting have declined. However, the health benefits from economic growth have not been shared equally among the Chinese population. There remain large disparities in the standard of health delivered to different sectors of the Chinese population. Rural children and children of minority nationalities continue to suffer from malnutrition and thus lower growth as compared to urban children. Economic reform has also changed the Chinese diet. Infant and child obesity is rising. Therefore, although economic reform has stimulated improvements in the growth of China s children, continued development and attention is needed in disadvantaged areas and populations. Public education is also necessary for China s children to avoid the diet-related diseases frequently seen in the west.
Subject(s)
Asian People , Body Height/physiology , Body Weight/physiology , Growth/physiology , Child , Child Development/physiology , Child, Preschool , China , Diet , Female , Health Care Reform , Humans , Infant , Male , Population Surveillance , Risk Factors , Rural Population , Socioeconomic Factors , Urban PopulationABSTRACT
This paper describes the cost-benefit analysis of a computerized medical record system for use in physicians' offices. Actual data for savings in physician time in paper work was collected. The qualitative benefits of the system were evaluated using a questionnaire. The cost-benefit ratios demonstrated that the use of a computerized medical system is justified.
