[Polyamine and middle-molecule peptide levels in patients with chronic myeloid leukemia during treatment]. / Soderzhanie poliaminov i srednemolekuliarnykh peptidov u bol'nykh khronicheskim mieloleikozom v protsesse lecheniia.

Proliferative activity of myeloblasts as well as the content of possible regulators of hemopoiesis--polyamines and medium-molecular peptides were investigated in the time course of chronic myeloid leukemia. It has been noted that their levels correlate with the leukemic process progressing, and with the response to the chemotherapy conducted.

[Middle molecules as an indicator of the degree of disruption of blood coagulation in hemophilia]. / Molekuly srednei massy kak pokazatel' stepeni narusheniia gemokoaguliatsii pri gemofilii.

The blood plasma levels of medium-mass molecules (MMM) have been studied by UV spectrophotometry in patients with hemophilia A, B, and AB. The hemocoagulation status has been estimated with the use of the parameters reflecting the general blood coagulation ability and with the correction tests, using the thromboplastin generation test. The MMM levels in all hemophilia forms under study have been found essentially elevated vs. those in health. A clear-cut relationship between the severity of hemostasis disorders, blood plasma MMM levels, and the coagulologic parameters has been demonstrated.

[Polyamine levels of the blood of healthy persons]. / Soderzhanie poliaminov v krovi zdorovykh liudei.

A fraction content of free and conjugated polyamines was studied in whole blood of 70 practically healthy persons. Spermine and spermidine were mainly found among the polyamines with some quantitative predominance of the latter. Putrescine was not observed in blood or its amount was not detected by means of spectrophotometry. The data obtained suggest that the free and conjugated polyamines should be studied simultaneously.