ABSTRACT
The aim of this study was to assess the prevalence and prognostic value of major alterations of portal flow in patients with steroid-treated alcoholic hepatitis. Fifty patients with severe, histologically proven alcoholic hepatitis were enrolled. Clinical data, liver test results, and hepatic Doppler ultrasound findings were collected at inclusion and at month 2. Patients were followed for 1 year or until death. Major changes in portal flow were defined as reversed or alternating flow in the portal trunk and/or in intrahepatic portal branches. Changes in portal flow were observed in 24 (48.0%) of 50 and 17 (39.5%) of 43 patients at inclusion and month 2, respectively. Univariate analysis showed that age older than 50 years, steatosis less than 20% on initial liver biopsy, presence of major changes in portal flow, Child-Turcotte-Pugh score higher than 12, factor V level higher than 45%, and hepatofugal splenic blood flow were associated with a lower 1-year survival. Cox regression analysis showed that steatosis < 20% (relative hazard [RH] = 9.3, P = .0009) and major changes in portal flow (RH = 3.1, P = .04), were independently associated with poor survival. In conclusion, major changes in portal flow are frequent in patients with severe alcoholic hepatitis. Altered portal flow and steatosis < 20% are new prognostic factors in steroid-treated alcoholic hepatitis and must be taken into account in patient management.
Subject(s)
Fatty Liver/drug therapy , Fatty Liver/physiopathology , Hepatitis, Alcoholic/drug therapy , Hepatitis, Alcoholic/physiopathology , Portal System/physiology , Steroids/therapeutic use , Adult , Biopsy , Fatty Liver/mortality , Fatty Liver/pathology , Female , Hepatitis, Alcoholic/mortality , Hepatitis, Alcoholic/pathology , Humans , Liver/drug effects , Liver/pathology , Liver/physiology , Liver Circulation , Male , Middle Aged , Multivariate Analysis , Prevalence , Prognosis , Survival RateSubject(s)
Carcinoma, Hepatocellular/diagnosis , Hepatitis C/complications , Liver Cirrhosis/virology , Liver Neoplasms/diagnosis , Biopsy , Carcinoma, Hepatocellular/therapy , Carcinoma, Hepatocellular/virology , Genotype , Hepacivirus/genetics , Hepatitis C/etiology , Hepatitis C/virology , Humans , Liver Neoplasms/therapy , Liver Neoplasms/virology , Male , Middle Aged , Neoplasm Recurrence, Local , Tomography, X-Ray Computed , Transfusion Reaction , UltrasonographyABSTRACT
AIM: To investigate the feasibility and efficacy of hepatitis C virus screening in drug users in an addiction out-patient unit. PATIENTS AND METHODS: All patients followed in an addiction out-patient unit were asked to undergo anti-hepatitis C virus antibody testing; further evaluation and treatment if indicated, were offered to positive patients. When treatment was initiated (Metavir score >=F2), patients were followed-up both by the hepatologist and the out-patient unit physician. RESULTS: Between July 1997 and September 2000, 404 consecutive patients (310 men, mean age: 32, alcohol intake >=50 g per day in 51%, 94% in opiate substitution program) were included. Sixty-six per cent (269/404) of patients agreed to undergo HCV antibodies testing: 84% had a positive test. 68% of these patients accepted ALT serum measurement and 120 had indications for liver biopsy. Eighty-eight liver biopsies were performed, showing severe fibrosis (Metavir score F3 or F4) in 20 cases (22%). Ethanol intake was significantly correlated to fibrosis (P<0.05). Antiviral treatment was indicated in 47 patients but was only initiated in 27 due to patient refusal (n=7) or contraindication (n=13). Treatment had to be discontinued in 12 cases because of psychiatric side effects (depression: n=3; delirium: n=3; severe irritability: n=3; relapse with heroin injection: n=3). Finally, only 5 patients were sustained responders. CONCLUSION: Despite the high seroprevalence of HCV antibodies in this unit, the benefits of antiviral therapy are low due to high drop out rate. Ethanol withdrawal should be the highest priority in these patients.
