[Cortisol metabolic intensity in the liver of guinea pigs in allergic processes of the immediate and delayed types]. / Intensivnost' metabolizma kortizola v pecheni morskikh svinok pri allergicheskikh protsessakh nemedlennogo i zamedlennogo tipov

The intensity of cortisol metabolism was studied under conditions of perfusion of the liver in situ by solutions containing cortisol in different concentrations; in this case metabolism coursed chiefly in the direction of cortisone formation. With the increase of cortisol concentration in the inflowing perusate there was also a rise in the intensity of its metabolism in the hepatic tissue. In anaphylactic alteration of hepatic tissue the intensity of cortisol transformation into cortisone decreased, this pointing to disturbances of cortisol oxidation. Experimental allergic encephalomyelitis is also acccompanied by a reduction in the intensity of cortisol metabolism.