ABSTRACT
Purpose: Coronavirus disease 2019 (COVID-19) is a highly formidable disease. Globally, multiple vaccines have been developed to prevent and manage this disease. However, the periodic mutations of severe acute respiratory syndrome coronavirus 2 variants cast doubt on the effectiveness of commonly used vaccines in mitigating severe disease in the Indian population. This study aimed to assess the effectiveness of the BBV152 vaccine and ChAdOx1-S vaccine in preventing severe forms of the disease. Materials and Methods: This retrospective study, based on hospital records, was conducted on 204 vaccinated COVID-19 patients using a consecutive sampling approach. Data on their vaccination status, comorbidities, and high-resolution computed tomography lung reports' computed tomography severity scores were extracted from their medical records. Fisher's exact test and binomial logistic regression analysis were employed to assess the independent associations of various factors with the dependent variables. Results: Of the 204 records, 57.9% represented males, with a mean age of 61.5±9.8 years. Both vaccines demonstrated effective protection against severe illness (90.2%), with BBV152 offering slightly better protection compared to ChAdOx1-S. Male gender, partial vaccination, comorbid conditions, and the type of vaccine were identified as independent predictors of severe lung involvement. Conclusion: This study indicates that both vaccines were highly effective (90%) in preventing severe forms of the disease in fully vaccinated individuals. When comparing the two vaccines, BBV152 was slightly more effective than ChAdOx1-S in preventing severe COVID-19.
ABSTRACT
Introduction: The COVID-19 pandemic is considered one of the most devastating situations globally, the worst affected were the senior citizens. A number of initiatives were carried out to control the COVID-19 pandemic; one such important measure is the development of COVID-19 vaccines to prevent the disease. But the continuous emergence of new SARS-COV2 variants (antigenic drift) and its demographic variation in virulence makes the vaccine's efficacy questionable. This study is intended to evaluate the association between the degree of lung involvement and the effectiveness of vaccination against the disease in cases admitted to a designated hospital in Tamil Nadu. Materials and Methods: A hospital records-based-retrospective research was conducted among COVID-19 patients admitted from the 1st of April 2021 to the 31st of May 2021, and information was gathered regarding their vaccination status, comorbid conditions, and CT severity score (CTSS) in the HRCT lung report. A consecutive sampling technique was used to choose the study participants; about 120 participants were included in the study. The Chi-square test and Fisher's extract test were used to evaluate the hypothesis. The relationship between a dependent variable and independent factors was estimated using multiple linear regression. Results: Among 120 participants, about 60.2% were males and 39.8% were females. Vaccination status and comorbid conditions had a significant association with severe lung involvement in COVID-19 patients. Conclusion: Non-vaccinated patients had severe lung involvement based on the HRCT lung scan findings than the vaccinated patients. To reduce mortality, it is essential to ensure universal coverage of COVID-19 vaccination.
ABSTRACT
Introduction: The tobacco epidemic is one of the biggest public health threats the world has ever faced, which kills more than 8 million people a year around the world. Transgenders are prone to use and abuse substances including tobacco and alcohol as a coping mechanism to manage minority stress experienced due to high levels of discrimination and lack of acceptance by society. Objectives: Among transgenders living in Chennai city, Tamil Nadu, (1) we aimed to estimate the prevalence and describe the pattern of tobacco use and (2) identify the sociodemographic factors associated with tobacco use. Methods: A community-based cross-sectional analytical study was conducted among 734 transgender adults living in the Chennai city of Tamil Nadu. A pre-tested, semi-structured interview schedule was used. Descriptive statistics such as frequency and proportions were used for categorical variables. Chi-square test was applied to find the significance of the association between tobacco use and sociodemographic factors. Results: The prevalence of the current use of any form of tobacco products among transgenders was 64.4%. About 27% had tried to stop using tobacco during the past 1 year. Education status, socioeconomic class, and occupation were significantly associated with the current use of any form of tobacco and trying to quit tobacco use. Conclusion: The prevalence of tobacco use among transgenders is alarming. The present study findings highlight the need to increase awareness activities by health authorities and non-government organizations (NGOs)/community-based organizations (CBOs) to generate awareness about the health hazards of tobacco use among transgenders. Tobacco control programs focussing on transgenders are essential.
ABSTRACT
INTRODUCTION: Rabies is a neglected zoonotic tropical disease that usually affects the poorest communities. Rabies is 100% fatal and at the same time 100% preventable. A huge proportion of death due to rabies occurs in Asia and Africa, and India is reported to have the highest incidence of rabies. AIMS: To assess the knowledge, attitude, and practice related to animal bites, rabies, and its prevention and utilization of health services for this purpose in the study population. METHODS: A community-based cross-sectional study done in an urban area among the age group 20 and above of both gender to assess and statistically highlight the knowledge, attitude, and practice related to animal bites, rabies, and its prevention and utilization of health services for this purpose in the study population. The sample size was estimated to be 350 and a simple random sampling technique was used for the selection of samples. RESULTS: About 76% had heard about rabies. Among them only 63.5% knew it is a fatal disease, only 37.6% knew animals other than dogs can also cause rabies, only 37.3% of the study participants knew about appropriate first aid. Only 37.5% of the animal bite victims washed their wound with soap and running water and 35% had a full course of vaccination. Education had been an important factor that created a significant difference in the knowledge level of the participants. CONCLUSIONS: Improved community awareness, forestalling animal rabies, and better access to affordable and potent human rabies vaccines are essential for the elimination of human rabies.
