ABSTRACT
ObjectiveTo estimate the prevalence of disability and anxiety in Covid-19 survivors at discharge from hospital and analyze relative risk by exposures. DesignMulti-center retrospective cohort study. SettingTwenty-eight hospitals located in eight provinces of China. MethodsA total of 432 survivors with laboratory-confirmed SARS CoV-2 infection participated in this study. At discharge, we assessed instrumental activities of daily living (IADL) with Lawtons IADL scale, dependence in activities of daily living (ADL) with the Barthel Index, and anxiety with Zungs self-reported anxiety scale. Exposures included comorbidity, smoking, setting (Hubei vs. others), disease severity, symptoms, and length of hospital stay. Other risk factors considered were age, gender, and ethnicity (Han vs. Tibetan). ResultsPrevalence of at least one IADL problem was 36.81% (95% CI: 32.39-41.46). ADL dependence was present in 16.44% (95% CI: 13.23-20.23) and 28.70% (95% CI: 24.63-33.15) were screened positive for clinical anxiety. Adjusted risk ratio (RR) of IADL limitations (RR 2.48, 95% CI: 1.80-3.40), ADL dependence (RR 2.07, 95% CI 1.15-3.76), and probable clinical anxiety (RR 2.53, 95% CI 1.69-3.79) were consistently elevated in survivors with severe Covid-19. Age was an additional independent risk factor for IADL limitations and ADL dependence; and setting (Hubei) for IADL limitations and anxiety. Tibetan ethnicity was a protective factor for anxiety but a risk factor for IADL limitations. ConclusionA significant proportion of Covid-19 survivors had disability and anxiety at discharge from hospital. Health systems need to be prepared for an additional burden resulting from rehabilitation needs of Covid-19 survivors.
ABSTRACT
Objective: To investigate the value of ultrasound guided intra-amniotic instillation of pulmonary surfactant (PS) combined with prenatal ambroxol hydrochloride (AH) for prevention of lung injury in preterm rabbits. Methods Totally 20 pregnant New Zealand rabbits were randomly divided into 4 groups (each n=5), i.e. ultrasound guided intra-amniotic instillation of PS before cesarean section (PS group), prenatal AH (AH group), ultrasound guided intra-amniotic instillation of PS combined with prenatal AH (PS+AH group) and control group. On the 27th day of pregnancy, rabbit fetuses were removed through cesarean section 1 hour after injection. The survival time of the preterm rabbits, the concentration of interleukin-6 (IL-6) and dipalmitoyl phosphatidylcholine (DPPC) in bronchoalveolar lavage fluid, the expression level of pulmonary surfactant-associated proteins-A (SP-A) in lung tissue were detected. And the lung tissue sections were taken to observe the degree of lung injury. Results: Compared with control group, the survival time of the preterm rabbits of PS group, AH group and PS+AH group prolonged, the concentration of IL-6 decreased, the concentration of DPPC and SP-A increased, and the pathological score of lung injury decreased (all P<0.05). There were significant differences between PS+AH group and PS, AH group in those indexes except for survival time (all P<0.05). Conclusion: Ultrasound guided intra-amniotic instillation of PS combined with prenatal AH plays a role in the prevention of lung injury in preterm rabbits.
ABSTRACT
Cultivation of wild Fritillaria glabra can be easily achieved without extra energy consumption simply by shading the seedbed from light to lower 2.7 to 3℃ C of bed temperature with concomitant increase of relative humidity. By so doing, ciltivation can be carried out on ground 1200m lower sea level than its native habitat. Successfal cultivation of F.glabra in Feng county, Shaxi Province, resulted in excellent thigh yield.
