ABSTRACT
The article deals with present-day evidence concerning the role of blood-platelet activity in the development of a pathological process and acute ischemia in patients presenting with chronic arterial insufficiency of the lower extremities. Proved herein is the necessity of long-term administration of antiplatelet drugs in order to prevent vascular complications on the part of the heart, brain, and peripheral arteries, with a description of the drugs most commonly used for these purposes.
Subject(s)
Arteriosclerosis Obliterans/drug therapy , Aspirin/therapeutic use , Fibrinolytic Agents/therapeutic use , Leg/blood supply , Platelet Aggregation Inhibitors/therapeutic use , Arteriosclerosis Obliterans/surgery , Aspirin/administration & dosage , Aspirin/adverse effects , Chronic Disease , Fibrinolytic Agents/administration & dosage , Fibrinolytic Agents/adverse effects , Hemorrhage/chemically induced , Humans , Middle Aged , Platelet Aggregation Inhibitors/administration & dosage , Platelet Aggregation Inhibitors/adverse effects , Stomach/drug effects , Time FactorsABSTRACT
The article deals with the main clinical and instrumental methods of determining severity of chronic arterial insufficiency of the lower extremities, showing possibilities of morphological studies for an accurate diagnosis of the ischaemia degree. Also determined are promising trends of studying the hypoxia-inducible factor (HIF) and vascular endothelial growth factor (VEGF) in assessment of ischaemic impairments of lower-extremities tissue.
Subject(s)
Arterial Occlusive Diseases/diagnosis , Biomarkers/blood , Leg/blood supply , Arterial Occlusive Diseases/blood , Chronic Disease , Disease Progression , Exercise Test , Humans , Hypoxia-Inducible Factor 1/blood , Prognosis , Severity of Illness Index , Vascular Endothelial Growth Factor A/bloodABSTRACT
Chair of Neurology of the Advanced Medical Training Department of the Federal Educational Facility of the Higher Vocational Education Russian State Medical University under the Russian Public Health Ministry, Moscow, Russia. The article deals with the findings obtained in examining and treating a total of eighty-seven patients suffering from atherosclerosis obliterans of the lower-limb arteries with stage IIB and III chronic arterial insufficiency. Studied were impairments of the theological properties of the blood and plasma, erythrocytic deformability and the concentration of malonic dialdehyde in blood at admission to the hospital, upon completion of the course of conservative treatment, and after the reconstructive vascular intervention performed. It was determined that the leading mechanism disturbing oxygen utilization by tissues is a decrease in erythrocytic deformability, which promotes shunting of the arterial blood flow and persists after the surgical vascular reconstruction preformed.
