Subject(s)
Cicatrix, Hypertrophic/diagnosis , Keloid/diagnosis , Acne Vulgaris/complications , Acne Vulgaris/metabolism , Burns/complications , Burns/metabolism , Cicatrix, Hypertrophic/etiology , Cicatrix, Hypertrophic/metabolism , Cicatrix, Hypertrophic/surgery , Cryosurgery , Humans , Keloid/etiology , Keloid/metabolism , Keloid/surgery , Skin/metabolismABSTRACT
The effectiveness of the use of a stabilized composition of alpha 2-macroglobulin concentrate obtained from fraction III of plasma proteins according to Cohn in burn disease in the experiment on guinea pigs was studied. Under the influence of intraabdominal administration for 4 days of alpha 2-macroglobulin concentrate with a stabilizer, healing of the burn wounds, normalization of a state of the animals occurred 2 times more rapidly than in control ones, activity of acid proteinases restored by day 5 (in control--by day 14) due to increase in activity of proteolytic enzyme inhibitors.
Subject(s)
Burns/drug therapy , alpha-Macroglobulins/therapeutic use , Animals , Disease Models, Animal , Female , Guinea Pigs , Injections, Intraperitoneal , Male , Time Factors , alpha-Macroglobulins/chemistryABSTRACT
The technique of dermotension, peculiarities and expediency of its use in postburn and mechanical skin deformation in 50 children ranging in age from 2 to 14 years are described. It is expedient to perform operative elimination of the postburn alopecia, severe contracture of the neck, cicatricial bandage of the chest and abdomen by means of the dermotensive flaps. This permits to reduce a number of operative steps, create a sufficient reserve of healthy tissue identical to the lost one both in texture and in colour. Dermotension has the advantages over the pediculate plasty and can be widely used in children with the burn sequelae.
Subject(s)
Burns/surgery , Tissue Expansion/methods , Adolescent , Burns/complications , Child , Child, Preschool , Contracture/etiology , Contracture/prevention & control , Humans , Wounds and Injuries/surgeryABSTRACT
The experience with performing operations in 17 patients with contracture of the neck, face, trunk with the use of composite cutaneous arterialized flaps from the lateral surface of the thoracic wall and inclusion of the latissimus dorsi has been analysed. It is established that such a plasty is attended by the lesser risk of circulatory impairement in the transferred tissues as compared with the available methods of non-free plasty.
Subject(s)
Burns/complications , Cicatrix/surgery , Contracture/surgery , Skin Transplantation/methods , Surgical Flaps , Adolescent , Adult , Arteries/transplantation , Child , Child, Preschool , Cicatrix/etiology , Contracture/etiology , Humans , Skin/blood supplyABSTRACT
In patients with pathological scars, especially in children, the activity of proteolytic enzymes (prekallikrein, acid and neutral proteinases) is increased. Summary inhibitory activity and content of the alpha 2-macroglobulin in the serum and scar tissue is also increased. This is indicative of continued inflammation.
Subject(s)
Burns/enzymology , Cicatrix/enzymology , Prekallikrein/metabolism , Protease Inhibitors/metabolism , alpha-Macroglobulins/metabolism , Adolescent , Adult , Aged , Burns/blood , Burns/complications , Child , Child, Preschool , Cicatrix/etiology , Enzyme Activation/physiology , Humans , Middle AgedABSTRACT
Biochemical and electron microscopy study of the collagen molecule from 14 biopsy specimens of the postburn scar (in 9 patients before and in 5 after cryoeffects) revealed that the postburn scar contains I, II, III and VIII collagen types changed according to the amino acid composition. It was found that after cryogenic effects on the scar there was a tendency to normalization of the collagen structure.
