Sensor extended imaging workflow for creating fit for purpose models in basic and applied cell biology.

While various engineering disciplines spent years on developing methods and workflows to increase their R&D efficiency, the field of cell biology has seen limited evolution in the fundamental approaches to interact with living cells. Perturbations are mostly of chemical nature, and physiologically relevant contexts and stimuli are left with limited attention, resulting in a solution space constrained within the boundaries of presently manageable perturbations. To predict in the laboratory how a drug will work in a human patient, cell biology must have a closer look at life and strive to mimic the human being in all his complexity. By implementing an iterative process from perturbation to measurement and vice versa, the authors suggest using a sensor-extended imaging workflow to implement product development practices to cell biology, opening a physiologically relevant solution space for the development of truly translational and predictive fit for purpose in vitro cell models.

Using Low-Cost Sensors to Develop a High Precision Lifting Controller Device for an Overhead Crane-Insights and Hypotheses from Prototyping a Heavy Industrial Internet Project.

The subject of this study was the product development project creating a new innovative proof-of-concept (POC) prototype device that could control a connected industrial overhead crane in order to perform automatic or semi-automatic high precision lifts within a limited time frame. The development work focused on innovating a new measuring concept, which was parallel to finding suitable sensors for the application. Furthermore, the project resulted in a closed loop control system with Industrial Internet connected sensors and a user interface for factory workers. The prototyping journey is depicted to illustrate the decisions made during the product development project to contribute to both the pragmatic and the process discussion in the field of Industrial Internet. The purpose of this research was to explore and generate hypotheses for how new applications should be developed for heavy industry connected devices. The research question is: what are the implications of applying agile product development methods, such as Wayfaring, to heavy industrial machinery and Industrial Internet -based problems? The methodologies used in this paper, in addition to developing the device, are case study research and hypotheses generated from case studies. The hypotheses generated include that it is also possible to prototype large size connected machinery with low-cost and in a short time, and investment decisions for heavy Industrial Internet products become easier with concrete data from proof-of-concept prototypes by creating knowledge about the investment risk and the value proposition.