[Prevention of polymorphous ventricular tachycardia in patients with congenital long QT interval syndrome]. / Moznosti prevencie polymorfnej komorovej tachykardie u pacientov s kongenitálnym syndrómom dlhého QT intervalu.

Patients with the Romano-Ward long QT interval syndrome run a high risk of sudden cardiac death. Beta-blockers of the sympathetic nerve are effective treatment. Some patients die suddenly despite this treatment. The treatment of choice is a combination of beta-blockers of the sympathetic nerve and cardiostimulation. The authors describe a group of their own five patients from three families with the Romano-Ward syndrome. The course was favourable. The stimulation rate needed for normalization of the QT interval and a favourable clinical development was 78 +/- 6 imp./min. Based on data in the literature and their own experience the authors recommended combined treatment with beta-blockers and cardiostimulation in patients with the Romano-Ward syndrome, if monotherapy with beta-blockers is not effective.

[Ischemic heart disease with significant coronary stenosis and insulin resistance]. / Ischemická choroba srdca so signifikantnými koronárnymi stenózami a inzulínová rezistencia.

The authors examined a group of 22 patients with significant stenoses revealed on coronarographic examination. None of the patients were diabetic. Hyperinsulinaemia was found in 12 patients (54.5%). The hyperinsulinaemic and normoinsulinaemic groups differed significantly as to the type of obesity expressed by the W/H ratio, the incidence of hypertension and triglyceride levels. The authors discuss the direct participation of insulin resistance and compensatory hyperinsulinism in the pathogenesis of atherosclerosis and its participation in the manifestation of associated risk factors (dyslipidaemia, hypertension, obesity and NIDDM).