1.
Distinct type-2A protein phosphatases activate HMGCoA reductase and acetyl-CoA carboxylase in liver.
FEBS Lett
; 413(1): 115-8, 1997 Aug 11.
Article
in English
| MEDLINE
| ID: mdl-9287127
ABSTRACT
Acetyl-CoA carboxylase and HMGCoA reductase are inactivated by the same AMP-activated protein kinase and are activated by type-2A protein phosphatase. To determine whether the same species of protein phosphatase-2A were involved, we studied the interconversion of acetyl-CoA carboxylase and HMGCoA reductase in isolated rat hepatocytes. We show that (i) these enzymes are differently regulated in hepatocytes and (ii) the species of type-2A protein phosphatase involved in their activation are different and can be separated by anion-exchange chromatography.