ABSTRACT
BACKGROUND: Bioactive glass (S53P4), abbreviated BG, currently seems to be the best material for reconstructing the posterior wall of the auditory canal and obliterating the postoperative cavity. PURPOSE: The aim of the study was to report preliminary results of otosurgery involving obliteration of the mastoid cavity after canal wall down mastoidectomy. METHODS: 11 adult patients who had had a history of chronic otitis media with cholesteatoma in one or both ears and previous canal wall down mastoidectomy. The duration of the follow-up was 6 months, with routine visits after 7 days, then 1, 3, and 6 months after surgery. The patient's medical history, noting other diseases potentially affecting the healing process, was analyzed. Healing, audiometric results, reduction of the volume of the cavity after surgery, and reduction of bacterial flora growth were assessed. RESULTS: There was not worsening in the audiological evaluation. Healing period was uneventful. There was a reduction in volume of the postoperative cavity, no development of pathological flora, and no recurrence of cholesteatoma. CONCLUSION: Obliteration of the mastoid process with S53P4 bioactive glass is a safe and effective method of treatment. Such a procedure should be considered as a treatment for patients after canal wall down surgery (CWD).
Subject(s)
Cholesteatoma, Middle Ear/surgery , Ear Canal/surgery , Glass , Mastoid/surgery , Mastoidectomy/methods , Otitis Media/surgery , Plastic Surgery Procedures/methods , Adult , Aged , Cholesteatoma, Middle Ear/complications , Cholesteatoma, Middle Ear/physiopathology , Chronic Disease , Female , Follow-Up Studies , Hearing , Humans , Male , Mastoid/microbiology , Mastoidectomy/adverse effects , Middle Aged , Otitis Media/complications , Otitis Media/physiopathology , Prospective Studies , Time Factors , Treatment OutcomeSubject(s)
Arteries/metabolism , Arteriosclerosis/prevention & control , Calcium Channel Blockers/administration & dosage , Calcium/metabolism , Lipid Metabolism , Models, Cardiovascular , Animals , Arteriosclerosis/etiology , Calcium Channel Blockers/pharmacology , Humans , In Vitro Techniques , Lipids/antagonists & inhibitors , RabbitsABSTRACT
Preservation of the quality of raw milk by activation of its natural lactoperoxidase (LP) system was studied. The milk was stored at 4, 10 and 17°C for a total period of 104, 72 and 48 h, respectively. At 4°C, the LP system was activated after 48 and 96 h. At the higher storage temperatures, activation was carried out initially and after 24 h and (at 10°C) 48 h of storage. The results show that, at 4°C, the Standard Plate Count in LP-activated milk remained fairly unchanged for at least 104 h, whereas bacterial multiplication in the controls started after 48 h. At 10°C, an activation resulted in a lag-phase of at least 72 h, but at 17°C this was reduced to below 24 h. The observed changes in the counts of coliforms and psychrotrophs followed the same general pattern. These results suggest that activation of the LP system in combination with moderate cooling (e.g., with available well water) could be a useful alternative to extend the keeping quality of raw milk. Overnight storage might then be possible, provided the initial hygienic quality of the milk is good and the milk is promptly taken care of in the morning.
