ABSTRACT
The correlations between serum HDL, total cholesterol, triglycerides or free fatty acids levels and the percentage of human peripheral blood lymphocytes bearing receptors for SRBC, MRBC, Con A or sIgG were sought in the aged people. The persons examined showed a marked heterogeneity in their serum lipid levels as well as in the results of lymphocyte surface receptor analysis. However, the only correlation found was that between the percentage of MRBC-rosette forming cells and the level of serum free fatty acids. The total cholesterol level, known as the modulator of some physical parameters of lymphocyte membrane, had, in our examination, no correlation with the changes of surface properties of lymphocytes. The possible physiological role of the phenomena observed is discussed.
Subject(s)
Lipids/blood , Lymphocytes/analysis , Receptors, Cell Surface/analysis , Age Factors , Aged , Animals , Cell Membrane , Cholesterol/blood , Cholesterol, HDL , Female , Humans , Immunoglobulin G/analysis , Lipoproteins, HDL/blood , Male , Mice , Receptors, Concanavalin A/analysisABSTRACT
Male and female mice were given oestradiol and its effect on the tissues in the lymphatic system were observed including the thymus, lymph nodes and spleen. The weight of these organs was determined together with the number of cells present in them, with the percent proportion of live cells, their proliferative ability and metabolic activity. The obtained results indicate that oestradiol exerts a suppressive effect on the cells of these organs both in males and females and that this effect is strongest in the thymus.
Subject(s)
Estradiol/pharmacology , Spleen/drug effects , Thymus Gland/drug effects , Animals , Female , Lymph Nodes/cytology , Lymph Nodes/drug effects , Lymphocytes/drug effects , Male , Mice , Organ Size , Spleen/cytology , Thymus Gland/cytologyABSTRACT
The authors determined the lymphocyte count, nucleo-cytoplasmic ratio, nuclear diameter, and the number of nucleoli and their morphology in peripheral blood of female mice. The results indicate that lymphocyte count remains unchanged during the sexual cycle but changes occur in the nucleocytoplasmic ratio, nuclear diameter, the number and morphology of lymphocyte nucleoli and are synchronized with the cycle. The observations suggest that changes in the maturity and activity of lymphocytes depend on the phase of the sexual cycle.
