ABSTRACT
The authors studied the effect of single intakes of metoclopramide on the acid and pepsin secretion in patients with chronic gastritis and duodenal ulcer. Peroral intake of 20 mg of metoclopramide during histamine-stimulated gastric secretion resulted in a distinct reduction of H ions and an insignificant reduction of pepsin secretion. Cerucal-initiated inhibition of acidity is accompanied by reduction of potassium concentration.
Subject(s)
Gastric Acid/metabolism , Gastritis/drug therapy , Metoclopramide/therapeutic use , Pepsin A/metabolism , Peptic Ulcer/drug therapy , Adult , Chronic Disease , Drug Evaluation , Female , Gastric Juice/drug effects , Gastric Juice/metabolism , Gastritis/physiopathology , Histamine , Humans , Male , Middle Aged , Peptic Ulcer/physiopathologyABSTRACT
Intragastric administration of a synthetic analog of prostaglandin E2 to patients with duodenal ulcers results in depression of the gastric acid production and in reduction of potassium level, leads to an elevation of the sialic acid debit and a rise of sodium concentration, not essentially changing calcium, chlorides, and pepsin levels. A combined analysis of gastric acid production and measurements of sialic acids, sodium and potassium detect the imbalance of the mucoid and bicarbonate secretion in peptic ulcers, this helping predict the disease course.
Subject(s)
Dinoprostone/therapeutic use , Duodenal Ulcer/drug therapy , Adolescent , Adult , Aged , Duodenal Ulcer/physiopathology , Electrolytes/analysis , Female , Gastric Acid/metabolism , Humans , Male , Middle Aged , Pepsin A/analysisABSTRACT
The content of electrolytes (Na+, K+, Ca2+) in human basal secrete has been determined before and after injection of histamine in gastric juice and insoluble mucus in healthy people. Electrolytes in the mucous membrane of the stomach, gastric juice and insoluble mucus have been determined in dogs with stomach fistula after Basow. Species peculiarities have been marked in electrolyte content change during gastric secretion.
