Lipid metabolism in young males with hypotestosteronaemia and oligospermia prior to, during, and after treatment.

Relationships between plasma testosterone levels and selected parameters of lipid metabolism were studied in a group of young sterile males prior to, during, and after hormone therapy. Initial hypertriacylglycerolaemia and decreased concentrations of HDL cholesterol returned to normal values after 30 days of methyltestosterone administration. LDL cholesterol concentrations decreased significantly as did plasma apolipoprotein B levels. These changes persisted also one month after cessation of treatment. The results suggest that restoration of initially decreased testosterone levels in the studied group of sterile males is associated with the restoration of the lipid profile.

Some measures of lipid metabolism in young sterile males before and after testosterone treatment.

The concentration of total cholesterol and triacylglycerols in plasma and their distribution in lipoproteins as well as the level of apolipoprotein-B and of endogenous testosterone were measured in 30 young sterile males before and after the treatment with methyltestosterone (Agovirin SPOFA) in a dose of 10 mg daily for 30 days. Before the treatment the level of total cholesterol in plasma and in VLDL fraction was normal, while that in LDL fraction was increased and in HDL fraction decreased. Similarly, the level of triacylglycerols in plasma was increased and correspondingly also the levels of that in all lipoprotein fractions. After the treatment no changes in total and VLDL cholesterol were found, while a significant decrease in LDL fraction and increase in HDL fraction was observed. Moreover, a significant decrease was found in a level of total plasma and VLDL triacylglycerols.

[Clinical experiences with mechanical and hormonal contraception]. / Klinické skúsenosti s mechanickou a hormonálnou antikoncepciou.

PIP: Over a 10-year period 2407 women were prescribed contraceptives: 2046 used the IUD DANA (Super, Special, Cor, Fix, and Lux), and 280 used hormonal contraceptives (Biogest, Brombiogest, Chlorbiogest, and Norbiogest). 51 women used Depo-Provera and 30 used the domestic Antiko-capiky, both chemical preparations. Pregnancy occurred with the IUDs in 9.03% of the cases, with the hormonal preparations in 2.9% of the cases, with Depo-Provera in .0% of the cases, and with Antiko-capiky in .3% of the cases. The IUDs caused complications in 8% hormonal contraceptives in 5%, Depo-Provera in 15%, and Antiko-capiky in 13%. The findings suggested that the higher the effectiveness of a method in preventing pregnancy, the greater the risk of detrimental side-effects, either directly from the area of the reproductive organs, or from the secondary connective systems. Study of the biochemical, endocrinological, and morphological factors and the physiological functions behind each of the contraceptive-related complications is deemed necessary in order to understand them in regard to each of the mentioned methods.^ieng

[Our experiences with the use of contraceptive preparation Depo-Provera]. / Nase skúsenosti s pouzitím antikoncepcného prostriedku Depo-Provera.

PIP: The contraceptive Depo-Provera (Upjohn), consisting of 150 mg of medroxyprogesterone acetate in 1 injection every 3 months, has a pregnancy index of .31. After injecting 51 patients with this contraceptive, menstrual cycles were closely observed. Of the 51, 6 women totally stopped menstruating; many of the rest experienced very irregular cycles. The considerable weight increase found in many cases is also to be considered. 2 women felt depressed, describing their cond ition as similar to that occurring during pregnancy. The number of pregnancies was 0. Considering the disturbance of the menstrual cycle, it is not advisable to prescribe this contraceptive to young women and women who are still planning to having children.^ieng