[Hypothalamo-hypophyseo-gonad system function in boys with an abnormal puberty syndrome]. / Funktsional'noe sostoianie gipotalamo-gipofizarno-gonadnoi sistemy u mal'chikov s sindromom nepravil'nogo pubertata.

The blood basal testosterone-, LH-, FSH levels, 17-CS and 17-HOCS excretion with the urine, circadian rhythms of testosterone-, LH- and FSH secretion were studied in 21 boys, aged 11 to 13 years, with abnormal puberty, manifesting in pronounced sexual hirsutism in the presence of infantile testicles. Functional tests, using chorionic gonadotropin, clomiphene citrate and spironolactone, were performed, as well. The blood level of testosterone and the change in its circadian secretion were markedly reduced in all the subjects under examination. 17-CS excretion with the urine was within normal, whereas that of 17-HOCS was increased, indicating the intensified adrenal functional activity. The study of the blood gonadotropic hormone basal level and circadian rhythms, as well as of the hypophyseal functional reserves revealed diverse changes in LH and FSH production, i.e. a high activity of the hypophyseal LH function and low FSH secretion were noted. The pathogenetic mechanisms of disturbed maturation in abnormal puberty are discussed.

[Androgenic function of the testes and gonadotropic activity of the pituitary gland in various forms of cryptorchism in children and adolescents]. / Androgennaia funktsiia iaichek i gonadotropnaia aktivnost' gipofiza pri razlichnykh formakh kriptorkhizma u mal'chikov i podrostkov.

Biochemical and radioimmunoassay of testosterone content in the blood and urine, epitestosterone and 17-CS level in the urine of 80 boys has shown, that the ovarian androgenic function is reduced in all the forms of cryptorchidism. The potential testis reserves are progressively lowered with the age in patients with bilateral and false retention and remain unchanged in unilateral cryptorchidism. In the absolute majority of patients the change in gonadotropic hormone production is noted, manifesting in the decreased and/or increased LH and FSH content in the blood of different patients, that is seemed to reflect heterogeneity of cryptorchidism pathogenetic forms. The ovarian testosterone production rise after chorionic gonadotropin injection did not inhibit the hypophyseal FSH activity.

[Blood serum immunoglobulins in small boys and adolescents with hypogonadism]. / Immunoglobuliny syvorotki krovi u mal'chikov i podrostkov, stradaiushchikh gipogonadizmom.

The immunoglobulin (Ig) concentration was studied in the blood serum of 31 boys with secondary hypogonadism. There was revealed a marked fall in the content of Ig of the A, M, and G classes, particularly of the M class, in all the patients before the treatment. After disappearance of the clinical hypogonadism signs and normalization of the blood testosterone level under the effect of chorionic gonadotropin therapy the plasma Ig concentration was found to be restored to the normal; the greatest relative elevation was revealed in case of IgM. Possible relations of testosterone with the immunocompetent organs and tissues are discussed.

[Correlation of the production of gonadotropic and sex hormones in boys and girls during sex maturation]. / Sootnoshenie produktsii gonadotrophykh i polovykh gormonov u mal'chikov i devochek v period polovogo sozrevaniia

PIP: There is an early period of puberty in boys at the age of 10 to 13, accompanied by an increase in the level of follicle stimulating hormone and a low secretion of luteinizing hormone and testosterone, with no secondary sexual signs. The beginning of an increase in the luteinizing hormone and testosterone concentration in boys coincides with the development of secondary sexual signs. The stabilization of the level of luteinizing hormone takes place in boys already at the 2nd degree of the sexual development. The secretion of luteinizing hormone at this point corresponds already to the normal level in adult men. The level of testosterone in the blood continues to increase and does not reach its definitive level until after the age of 17, or at the 5th degree of sexual development. Like in boys, the increase of the follicle stimulating hormone in girls precedes the increase of the luteinizing hormone secretion. The beginning of the increase in the follicle stimulating hormone coincides with an increase in the level of estrogens and testosterone in the blood, and with the appearance of secondary signs of sexual maturation. The increase of the luteinizing hormone secretion takes place later in girls than in boys and is accompanied by a new and significant increase in the level of estrogens in the blood. At the 2nd degree of sexual development, the level of testosterone in the blood of girls is substantially higher than at the other stages.^ieng