ABSTRACT
A model of traumatic osteomyelitis in rats is created. The disease development was evaluated by bone marrow myelograms, results of scintigraphy, and histological studies.
Subject(s)
Femur/injuries , Osteomyelitis/pathology , Animals , Animals, Outbred Strains , Bone Marrow/immunology , Bone Marrow/pathology , Disease Models, Animal , Femur/immunology , Femur/pathology , Male , Osteomyelitis/etiology , Osteomyelitis/immunology , RatsABSTRACT
The influence of Saussurea controversa DC and Fillipendula ulmaria (L.) Maxim extracts on the immunological reactivity of rats with experimental osteomyelitis has been studied. The application of these extracts on the background of antibiotic therapy normalized the immunological reactivity indices: (i) reduced the levels of total immunoglobulins, IgM and IgG and (ii) increased the percentage of active neutrophils and their absorption capacity, as well as the percentage of completion of phagocytosis. The treatment with plant extracts reduced the acute inflammatory reaction and increased the total number of megakaryocites as compared to those upon antibiotic therapy.
Subject(s)
Filipendula/chemistry , Osteomyelitis , Plant Components, Aerial/chemistry , Plant Extracts/pharmacology , Saussurea/chemistry , Animals , Immunoglobulin G/immunology , Immunoglobulin M/immunology , Male , Osteomyelitis/drug therapy , Osteomyelitis/immunology , Osteomyelitis/pathology , Phagocytosis/drug effects , Plant Extracts/chemistry , Rats , Rats, WistarABSTRACT
Acute experimental hepatitis was induced by a single injection of 1% water solution of allyl spirit in a dose of 100 mg/kg. Morphofunctional state of peripheral blood and bone marrow cells was studied with the use of hematological and cytochemical methods. Specific changes were detected in the peripheral blood and bone marrow cell parameters in the early (6 and 12 h) and late (24h--10 days) periods after the injection. Changes in the liver and in the blood and bone marrow cells were irreversible. Most of the parameters studied returned to normal 22 days after the injection of allyl spirit.
