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Eksp Klin Farmakol ; 57(1): 13-5, 1994.
Article in Russian | MEDLINE | ID: mdl-8142853

ABSTRACT

Experimental studies were undertaken to examine azacaine used in mice during conduction anesthesia and in rabbits during epidural anesthesia in 0.75, 2 and 0.75, 1% solutions, respectively. It was found that azacaine in the above doses is 1.5-3.5-fold superior to 2% solutions of lidocaine (xycaine) and trimecaine (mesocaine) in their effect duration. Histological studies of the rabbit spinal cord after epidural azacaine administration revealed no significant changes in brain tissues.


Subject(s)
Anesthesia, Conduction , Anesthesia, Epidural , Anesthetics, Local , Pipecolic Acids , Animals , Dose-Response Relationship, Drug , Drug Evaluation, Preclinical , Lidocaine , Male , Mice , Rabbits , Trimecaine
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