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Oftalmol Zh ; (3): 181-4, 1989.
Article in Russian | MEDLINE | ID: mdl-2797684

ABSTRACT

Experiments on 82 rabbits (162 eyes) have shown that RNA hydrolysate phonophoresis possesses a pronounced protective action by stimulating a rapid cupping of metabolic disturbances and a restoration of the chemical state of cellular elements of the retina in a relatively remote terms after the introducing of a monobromoacetate inhibitor (within first 3 days). Experimental therapy beginning 10 days after the introducing of monobromoacetate, i. e. in the period when, besides metabolic disturbances histomorphologic changes were also seen, considerably stimulated activation of compensatory-inflammatory processes. The investigations carried out allow to recommend RNA hydrolysate phonophoresis for clinical examination in dystrophic diseases of the retina.


Subject(s)
Oligoribonucleotides , Phonophoresis , Retinal Degeneration/drug therapy , Ribonucleotides/administration & dosage , Acetates/poisoning , Animals , Drug Evaluation, Preclinical , Female , Histocytochemistry , Male , Rabbits , Retina/drug effects , Retina/metabolism , Retinal Degeneration/chemically induced , Retinal Degeneration/metabolism , Time Factors
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