[Radioprogestins. Their clinical use]. / Radioprogestinas. Su utilidad clínica.

It was obtained by synthesis a radioprogestin-iodine-131 and proved in two patients with hormono-dependent meningioma to progesterone with very good results in the scan of cerebral tumours localization; and in one patient in the treatment of this kind of tumour. No radiotoxicity or intolerance was present until today in six month of follow-up of this preliminary uses of radioprogestin in cerebral tumours hormono-dependent to progesterone; so it is proposed the use of this new radiopharmaco for the diagnosis and treatment of this tumours.

[Radioactive antiestrogens: their clinical use]. / II. Antiestrógenos radiactivos: su utilidad clínica.

Using antiestrogen labelled with iodine-131 we proved the useful as diagnostic and therapeutic tools to identified hormone dependent cancers in breast with very encorageous results in 7 cases of human cancer. The method was simple and safe and similar methods for scanning of prostate tumors dependent are in current research in our laboratory and will be object of other communications.

Scan of Hypothalamic Satiety Centers in the Control of Obesity: a preliminary report.

Using thioglucose labeled with goid-1 98 (Au-1 98) at doses of 2OµCi per patient, we took specific scans of the hypothalamic satiety centers in 50 normal volunteers and in 50 obesity patients, due to the ability of the hypothalamic satiety centers to take up thioglucose in their glucostat receptors. From the 50 obesity patients, two were classified as having hypothalamic obesity. The rest were controlled with serial scans in combination with nutritional, surgery and clinical control of obesity, with satisfactory results for the 'obesity team'.

Cysticercosis of the nervous system. Treatment by means of specific internal radiation.

Five hundred patients with cysticercosis of the nervous system were evaluated by scanning that used anti-Cysticercus antibodies labeled with indium 113. The same antibodies, labeled with iodine 131, were used for radioimmunotreatment. Ninety-six percent of the patients had good or excellent results, whereas only 4% had poor results. None of the patients showed intolerance or radiotoxicity during three months of clinical and laboratory follow-up. The diagnosis, treatment, and prognosis of cysticercosis of the nervous system are dramatically changing, due to the development of anti-Cysticercus antibodies labeled with radionuclides.

[Diagnosis and treatment of toxoplasmosis by means of radionuclide]. / Diagnóstico y tratamiento de la toxoplasmosis utilizando radionúclidos.

Using antibodies against Toxoplasma gondii labelled with indium-113 metaestable we obtained scan of rats infested with this disease in a simple and harmless way. Also using the same antibodies, but labelled with iodine-131, we destroyed by radiolysis the toxoplasmas of experimental animals with the Medial Lethal Dose obtained "in vitro" experiments. The experimental results are very encouraging and their use in human beings are in currently research in our laboratory and will be the object of a future communication.

[Diagnosis and treatment of trichinosis by means of radionuclide]. / Diagnóstico y tratamiento de la triquinosis utilizando radionúclidos.

Using the same technique that gave such good results in cysticercosis and other parasitic diseases we obtained antibodies labelled against trichinosis and proved their diagnostic value by scan in infected rats. These same antibodies at lethal dose, median, (LD50) radiolysed trichina larvae without damage to the animal. Experimental results are very encouraging and their potential use in human subjects are undergoing research in our laboratory and will be the object of a future report.

Preliminary report: radioimmunoscan of sympathetic ganglia and adrenal medulla.

The nerve growth factor is a polypeptide isolated from the salivary glands of certain laboratory animals. Its greatest physiological effect is on the autonomic nervous system. When antiserum against this nerve growth factor was injected in newborn animals nearly total destruction of the sympathetic ganglia was noted, a procedure known as immunosympathectomy. The anti-nerve growth factor labeled with 131iodine was injected in rats to determine organ distribution at different intervals (2, 4, 6, 8 and 24 hours). A selective concentration was obtained in the sympathetic ganglia and adrenal medulla (adrenal ganglia) 4 hours after the intravenous injection of 50 muCi. 131Iodine anti-nerve growth factor, with a specific activity of 0.001 gm. per mCi., permitted scanning of this structure for the first time. No intolerance or radiotoxicity has been observed in the animals and the results are encouraging. Radioimmunoscanning of the sympathetic ganglia and adrenal medulla in the human and radioimmunosympathectomy of the structures are being studied currently and will be subjects of future communications.

[Gammagraphy of the carotid glomus]. / Gammagrafía del glomus carótidec

Using the colorant proteic complex labell with Tc-99 m. we visualize--by the first time--the carotideal glomus in the human in 6 volunteers and one patient with tumor. The results are very encorageous: the method was simple and safe (one single dose endovenously) and hardless (no radiotoxicity presents in 3 months of clinical and laboratory controls) and there is a good visualization by scan of carotideal bodies "in vivo", in human being. We think this new method and labell compound could be useful in research and medical diagnoses.

[Scintillography of the adrenal medulla]. / Centelleografia de la medula adrenal

The "nerve growth factor" is a polipeptide isolated from salivary glands of some mammals. Its main physiological effect is on the autonomic nervous system. The injection of antiserum in newborn animals leads to nearly total destruction of the sympathetic ganglia (immunosympathectomy). Anti-nerve growth factor labelled with Iodine-131 was injected in rats for the determination of organ distribution at different times (2,4,6,8 and 24 hours). A selective concentration in the adrenal medulla was obtained at 4 hrs. after intravenous administration of 50 uCi of anti-nerve growth factor with an specific activity of 0.001 g/mCi that permits, for the first time, the scan of the adrenal medulla. No intolerance or radiotoxicity was observed in the animals during a six-month follow-up period. The results are very encoragin, and the application of this new method in humans is at present under study.

Basal ganglia scans in the human.

Using a 64Cu complex, we obtained human basal ganglia scans in three normal volunteers and in one patient with Wilson's disease with an oral dose of 1 mCi. The method with this new radioactive compound was simple and safe and the results were very encouraging.

[Hypophyseal gammography in man. Preliminary report]. / Gammagrafía hipofisaria en el ser humano. Informe preliminar

Two normal individuals (healthy volunteer) and one patient with pituitary adenoma were evaluated with estrogenic complex 131-I for pituitary scan. All of them receive 400 muCi of the radionuclide orally. The study was performed 24 hs. after the ingestion of the drug. The results obtained with this method were so encouraging: one side, any toxic reaction was detected through a period of three months, clinical nor laboratory; other side, we visualized directly and in an no invasive form, the pituitary gland with only one dose of the drug administered orally. It is necessary more investigation for a good evaluation of this.