[Characteristics of the microcirculation and blood rheology in arterial and venous forms of mesenteric vascular occlusion]. / Osobennosti mikrotsirkuliatsii i reologii krovi pri arterial'noi i venoznoi formakh okkliuzii mezenterial'nykh sosudov.

The functional properties of microcirculation and rheology of blood were studied in dogs subjected to arterial and venous occlusion of mesenteric vessels (cranial mesenteric artery and cranial mesenteric vein). It was found that a local alterations of microvascular bed of intestinal wall are quite different in case of arterial or venous occlusion. The degree of hemorheological and microvascular deviations is higher in case of acute venous thrombosis than during the acute occlusion of cranial mesenteric artery.

[Prevention by alpha and beta adrenoreceptor agonists and lithium hydroxybutyrate of injuries to the endothelium of the rabbit aorta induced by catecholamines]. / Preduprezhdenie i alpha- i beta-antagonistami adrenoretseptorov i oksibutiratom litiia povrezhdenii éndoteliia aorty krolika, vyzyvaemykh katekholaminami.

The damage of endothelial cells and intercellular junctions caused by 10 microM epinephrine (E) and 10 microM norepinephrine (NE) has been observed in perfused rabbit aorta. Simultaneous perfusion of the rabbit aorta with E and NE induced marked endothelial injuries at very low drug doses (0.1 microM). Alpha- and beta-adrenoceptor antagonists prevented the development of catecholamine-induced endothelial alterations. Lithium hydroxybutyrate partially prevented endothelial alterations caused by 10 microM epinephrine, but blocked completely morphological injuries caused by simultaneous perfusion of the rabbit aorta with 0.1 microM E and NE.

[Change in the morphology and permeability of perfused rabbit arteries in the phase of acute elevation of intravascular pressure]. / Izmenenie morfologii i pronitsaemosti perfuziruemykh arterii krolika v fazu ostrogo povysheniia vnutrisosudistogo davleniia.

Morphological changes of the endothelium were induced by acute elevation of intravascular pressure in the normal perfused rabbit aorta from 100 to 250 mm Hg. The number of argyrophilic cells and stigmata per 1 mm2 of the luminal surface has significantly increased. The acute rise in intravascular pressure was followed by a 2-fold and 20-fold increase in the uptake of 125I-labelled low density lipoproteins in intact endothelial areas and denudation areas, respectively. The acute rise in intravascular pressure is suggested to increase the uptake of 125I-labelled LDL in the areas of damaged, but not in the areas of intact endothelium.