Subject(s)
External Fixators , Fracture Fixation/instrumentation , Fracture Healing/drug effects , Fractures, Bone/therapy , Meglumine/analogs & derivatives , Multiple Trauma/therapy , Pelvis/injuries , Succinates/therapeutic use , Accidents, Traffic , Follow-Up Studies , Fractures, Bone/diagnosis , Fractures, Bone/etiology , Humans , Meglumine/therapeutic use , Multiple Trauma/diagnosis , Multiple Trauma/etiology , Pelvic Bones , Retrospective Studies , Treatment OutcomeABSTRACT
The investigation showed that reamberin application in the complex treatment of patients with severe disintegrated fractures of pelvic bones is pathogenetically grounded. Despite polyetiological origin of critical conditions in the organism in this case, all these have a common pathophysiological basis of three main processes: hypoxia, intoxication, and immunosuppression. Succinic acid, which is contained in reamberin, is a substrate antihypoxant that stimulates the synthesis of restorative equivalents in the cell. A modifying effect of succinic acid on the processes of tissue metabolism, including cell respiration, LPO/AOS system, and synthesis of proteins, is the basis of pathophysiological ground of reamberin application in a complex treatment of patients with disintegrated fractures of pelvic bones.
