[Effects of nirmin on central hemodynamics in patients with heart failure in the acute period of myocardial infarct]. / Vliianie nirmina na tsentral'nuiu gemodinamiku u bol'nykh s serdechnoi nedostatochnost'iu v ostrom periode infarkta miokarda.

Nirmin, a novel dosage form of nitroglycerin, was used to treat heart failure in 47 patients on days 1-3 after acute myocardial infarction. The drug was intravenously injected at 12-400 micrograms/min for 3-24 hours. Central hemodynamic changes were evaluated from equilibrium radionuclide ventriculographic data and pulmonary diastolic and central venous pressures. Nirmin improved the clinical status in 89.3% of the patients. Hemodynamic effects of the agent were manifested by reduced myocardial preload and its improved contractility, followed by elevated left ventricular ejection fraction and decreased hypokinesia of the myocardial affected areas.