ABSTRACT
The anticarcinogenic effects of bioginseng and two germanium-selective drugs produced by cultivating cells of ginseng radix (Panax ginseng C. A. Mey) in a conventional medium or in media containing organogermanium compounds were studied. Squamous-cell carcinomas of the uterus cervix and vagina were induced by intravaginal applications of 7,12-dimethylbenz(a)anthracene in mice. The drugs of ginseng were used orally or intravaginally during a long period of time of the postinitiation stage of carcinogenesis. All the drugs used locally effectively inhibited the development of induced carcinomas of the uterus cervix and vagina. When orally used, the drugs of ginseng exhibited only an insignificant tendency to inhibit the carcinogenesis of uterus cervix and vagina. The anticarcinogenic effects of the compared drugs were similar.
Subject(s)
Anticarcinogenic Agents/administration & dosage , Panax , Plants, Medicinal , Precancerous Conditions/prevention & control , Uterine Cervical Neoplasms/prevention & control , Vaginal Neoplasms/prevention & control , 9,10-Dimethyl-1,2-benzanthracene , Animals , Cells, Cultured , Chi-Square Distribution , Drug Screening Assays, Antitumor , Female , Germanium/pharmacology , Mice , Mice, Inbred Strains , Organometallic Compounds/pharmacology , Panax/drug effects , Plant Extracts/administration & dosage , Precancerous Conditions/chemically induced , Precancerous Conditions/mortality , Uterine Cervical Neoplasms/chemically induced , Uterine Cervical Neoplasms/mortality , Vaginal Neoplasms/chemically induced , Vaginal Neoplasms/mortalityABSTRACT
The influence of official drug bioginseng produced from cultivated cells of ginseng radix (Panax ginseng C. A. Mey) on carcinogenesis of the mammary gland was studied. Adenocarcinomas of the mammary gland were induced in rats by single intramammary injections of N-methyl-N-nitrosourea (MNU) at a dose of 1 mg per gland into the tissues of all 12 mammary glands. Bioginseng was given per os at a daily dose of 0.5 ml per rat for 27 weeks beginning 1 week after the MNU administration. Bioginseng and the control MNU-group decreased the incidence and multiplicity of the mammary gland tumors at 44 and 62% respectively. By radioimmune assay it was found that bioginseng normalised abnormally high level of estradiol in blood of rats treated by MNU.
Subject(s)
Adenocarcinoma/prevention & control , Antineoplastic Agents/therapeutic use , Mammary Neoplasms, Experimental/prevention & control , Panax , Plants, Medicinal , Adenocarcinoma/blood , Adenocarcinoma/chemically induced , Animals , Cells, Cultured , Estradiol/blood , Female , Mammary Neoplasms, Experimental/blood , Mammary Neoplasms, Experimental/chemically induced , Methylnitrosourea , Plant Extracts/therapeutic use , Rats , Rats, WistarABSTRACT
The study was concerned with the inhibitory effect of officinal preparations of phytoadaptogenic drugs such as bioginseng and Eleutherococcus senticosus and Rhaponticum carthamoides root extracts on the carcinogenesis induced by transplacental administration of N-nitrosoethylurea. The phytodrugs were given orally over a year. The administration of the drugs was followed by longer survival of the rats and lower occurrence and/or multiplicity of tumors (mainly those of the central nervous system). The drugs were placed in the order of decreasing anticarcinogenic activity as follows: bioginseng, Rhaponticum carthamoides extract and Eleutherococcus senticosus extract.