[Recovery of impaired respiratory activity in cats by thyroliberin analog (PR-546) devoid of hormonal properties]. / Vosstanovlenie narushennoi dykhatel'noi aktivnosti koshek analogom tiroliberina (PR-546), lishennym gormonal'nykh svoistv.

Synthetic analogue thyroliberin (PR-546) devoid of hormonal activity, recovered respiration in conditions of hyperventilation, two-sided vagotomy and hypoxia, caused by the 40-70% bleeding. PR-546 (in doses 100-500 micrograms/kg) intravenously injected was shown to abolish diagram activity decreased effect after hyperventilation. Injection of PR-546 to vagotomized cats in 1.5-2 h, increased breathing rate. The breathing activity resumed after long breaks in respiration as a result of peptide injection. The responses to analogue introductions is similar to the thyroliberin effect.

[Recovery from disorders of respiratory activity in cats using thyroliberin]. / Vosstanovlenie narushennoi dykhatel'noi aktivnosti koshek tiroliberinom.

Controlled lung hyperventilation in cats inhibited the activity of the diaphragm muscle with a subsequent stop of respiration after the end of hyperventilation. Thyroliberin (20-30 mg/kg) intravenously was shown to abolish these effects 15-20 min after application. Preliminary introduction of thyroliberin prevented the changes in the respiration rate and depth caused by vagotomy.