ABSTRACT
The distribution of iodine-125 labeled human alpha-fetoprotein in mice was studied after its intravenous injection. The maximal accumulation of alpha-fetoprotein in different tissues and organs of animals was observed mainly 5 hours after injection. Then the protein was gradually eliminated from the body. In the liver, intestine and blood of intact animals 125I-alpha-fetoprotein persists for at least three days. Accumulation of alpha-fetoprotein in various tissues and organs may determine the different biological effects of this protein. In the mice with transplanted lymphatic leukemia cells P388 the high level of alpha-fetoprotein accumulation was detected in the tumor tissue, reaching 6% of the injected amount per 1 g of tissue. This allows considering the radionuclide-labeled alpha-fetoprotein as a promising medical radionuclide marker for the radiological detection of malignant tumors.
Subject(s)
Iodine Radioisotopes/pharmacokinetics , Leukemia, Lymphoid/metabolism , alpha-Fetoproteins/pharmacokinetics , Animals , Female , Humans , Injections, Intravenous , Intestinal Mucosa/metabolism , Liver/metabolism , Mice , Mice, Inbred DBA , Radionuclide Imaging , Tissue Distribution , Xenograft Model Antitumor AssaysABSTRACT
The effect of nightly temperature drops of different durations (2, 4, and 6 h) on the processes of apical and axillary meristem organogenesis was studied in young Cucumis sativus L. under short photoperiod (day/night, 10/14 h), long photoperiod (16/8 h), and continuous light. Nightly temperature drops for 2 h had no effect on cucumber development under all studied photoperiods; however, longer temperature drops (4-8 h) accelerated the development under long photoperiod and continuous light. Short-term exposures to low temperature under continuous light considerably increased lateral branching of cucumber plants.
