[Treatment of trophic ulsers of different etiology].

The research included 40 patients with chronic trophic ulcers of lower extremities of different etiology (arterial insufficiency - 14 patients, venous insufficiency - 20 patients, diabetic foot syndrome - 6 people). According to the data of prime bacteriological inoculation, the main pathogens were: gram-positive coccus (Staphylococcus spp., Staphylococcus aureus - 75%, Staphylococcus epidermidis - 7,5%) and yeast-like fungi (Candida albicans - 7,5%). Microbial semination in plentiful quantity (more than 106 KOE) was detected at first inoculation in 85% of the patients. The ointment was applied for the patients. After 20 days, the lack of growth and the decrease of contamination level (lower than critical (less than 102 KOE) were noted. A visual analog scale estimated an intensity of pain in patients and it consisted of 39,8% before the treatment, 27,1% - after 10 days, 14,6% - after 20 days. The "Oflomelid" application allowed the reduction of the terms of wound cleansing from nonviable tissues in majority of patients and gained the fast transition from the granulation to epithelization phase. The principle of wound management with the application of ointment "Oflomelid" should be followed in a moist environment. A modern wound dressing must be used after the ointment. This shortened the terms of separate-phase wound repair and decreased the terms of the whole period of trophic ulcers repair in patients with vascular and endocrine pathology.

[The results of using cytoflavin in conservative treatment of patients with obliterating atherosclerosis of the lower extremity vessels].

Results of conservative treatment of 31 patients with PAD are presented. In 3 and 6 months after 10 everyday intravenous infusions of Cytoflavin (combination of succinic acid, inosine, nicitinamide and riboflavin) average increase of painfree walking distance among nonsmokers was 50.6% and 64.4% vs. 108.0% and 170.5% in subgroup of smokers respectively. Average increase of maximal walking distance in subgroup of nonsmoking and smoking patients was respectively 30.1% and 130.5% in three months and 37.6% and 144.8% in 6 months after Cytoflavin infusions.