1.
J Biol Chem
; 259(21): 13011-6, 1984 Nov 10.
Article
in English
| MEDLINE
| ID: mdl-6092359
ABSTRACT
The stereochemistry of the major isomer of 14,15-dihydroxy-5,8,10,12-eicosatetraenoic acid formed from 15-hydroperoxyeicosatetraenoic acid in human leukocytes was determined. The structure (erythro-14(R),15(S]-14,15-dihydroxy-5,8-cis-10,12-trans-eicosatetraenoi c acid) was assigned based on sodium arsenite thin-layer chromatography, NMR spectroscopy, and comparison with material prepared by total synthesis. This compound was found to inhibit leukotriene B4-induced superoxide anion generation in human neutrophils (IC50 = 10(-8)-10(-7) M). Superoxide anion generation induced by either formylmethionyl-leucyl-phenylalanine or arachidonic acid was not affected.
Subject(s)
Blood Platelets/physiology , Leukotriene B4/analogs & derivatives , Neutrophils/physiology , Arachidonic Acid , Arachidonic Acids/pharmacology , Chromatography, High Pressure Liquid , Chromatography, Thin Layer , Gas Chromatography-Mass Spectrometry , Humans , Indicators and Reagents , Leukotriene B4/blood , Leukotriene B4/chemical synthesis , Leukotriene B4/pharmacology , Magnetic Resonance Spectroscopy , N-Formylmethionine Leucyl-Phenylalanine/pharmacology , Neutrophils/drug effects , Superoxides/blood
2.
Prostaglandins
; 10(5): 807-12, 1975 Nov.
Article
in English
| MEDLINE
| ID: mdl-1215543
3.
Methods Enzymol
; 43: 388-404, 1975.
Article
in English
| MEDLINE
| ID: mdl-1134365
Subject(s)
Anti-Bacterial Agents , Magnetic Resonance Spectroscopy , Methods , Molecular Conformation , Solvents
4.
J Org Chem
; 37(21): 3290-3, 1972 Oct 20.
Article
in English
| MEDLINE
| ID: mdl-5072899
5.
J Am Chem Soc
; 92(26): 7591-3, 1970 Dec 30.
Article
in English
| MEDLINE
| ID: mdl-5490719
6.
Tetrahedron Lett
; (56): 4901-4, 1970 Dec.
Article
in English
| MEDLINE
| ID: mdl-5500064
7.
Steroids
; 11(6): 787-98, 1968 Jun.
Article
in English
| MEDLINE
| ID: mdl-5671486
Subject(s)
Pregnanes , Chemical Phenomena , Chemistry , Magnetic Resonance Spectroscopy , Spectrum Analysis
8.
J Am Chem Soc
; 89(10): 2444-7, 1967 May 10.
Article
in English
| MEDLINE
| ID: mdl-6042748
9.
J Am Chem Soc
; 89(10): 2454-9, 1967 May 10.
Article
in English
| MEDLINE
| ID: mdl-6042750