ABSTRACT
The pharmacological activity of a pediatric formulation of the phenolic hydrophobic drug propolis was studied in the experiments on albino rats of various age with toxic liver damages of various duration and in acute hepatic ischemia. In all models of hepatic abnormalities, the drug was found to show antioxidative properties which were moderate (30-60%). In addition, there were improvements in hepatic secretion of bile, cholic acids, and cholesterol. On the other hand, the membrane-stabilizing effect of the drug was exerted in not all the tested models of hepatic damage.
Subject(s)
Aging/drug effects , Liver/drug effects , Propolis/administration & dosage , Acute Disease , Animals , Carbon Tetrachloride Poisoning/drug therapy , Chemical and Drug Induced Liver Injury/drug therapy , Disease Models, Animal , Drug Evaluation, Preclinical , Ischemia/drug therapy , Liver/blood supply , Propolis/pharmacology , Rats , Rats, WistarSubject(s)
Liver/drug effects , Superoxide Dismutase/therapeutic use , Acute Disease , Animals , Bile/drug effects , Bile/metabolism , Carbon Tetrachloride Poisoning/drug therapy , Carbon Tetrachloride Poisoning/metabolism , Carbon Tetrachloride Poisoning/mortality , Chemical and Drug Induced Liver Injury/drug therapy , Chemical and Drug Induced Liver Injury/metabolism , Chemical and Drug Induced Liver Injury/mortality , Drug Evaluation, Preclinical , Flavonoids/therapeutic use , Liver/metabolism , Mice , Plant Extracts/therapeutic use , Rats , Rats, WistarABSTRACT
The albino rat experiments studied the pharmacological action of oxycinnamic acid derivatives in acute tetrachloromethane-induced hepatic dystrophy and combined CCl4-ethanol-induced hepatic lesion. The tested agents were found to produce cholagogic, membrane-protective, and antioxidative effects in these hepatic abnormalities, thus improving the functional (cholate- and glycogen-synthetic) parameters of the liver.
Subject(s)
Chemical and Drug Induced Liver Injury/drug therapy , Coumaric Acids/therapeutic use , Acute Disease , Animals , Carbon Tetrachloride Poisoning/complications , Carbon Tetrachloride Poisoning/drug therapy , Chemical and Drug Induced Liver Injury/etiology , Drug Evaluation, Preclinical , Ethanol/toxicity , Flavonoids/therapeutic use , Liver/drug effects , Plant Extracts/therapeutic use , Rats , Rats, Wistar , Vitamin E/therapeutic useABSTRACT
The hepatoprotective activity of 16 derivatives of +hydroxycinnamic acids was studied on the model of acute tetrachloromethane-induced hepatitis. The effects of the agents administered in doses of 5, 15, and 30 mg/kg were compared with those of silibor, vitamin E and flamine. The studied compounds were shown to possess the bile-expelling, antioxidant and membrane-protective effects being superior in some cases to similar effects of reference drugs. The structure-activity relationship was established.
