[Neonatal seizures: consider sinus thrombosis]. / Neonatale convulsies: denk aan een sinustrombose.

Cerebral sinovenous thrombosis is a possible cause of neonatal seizures. It can be demonstrated by neuroradiological Doppler ultrasound or MRI/MRV. Maternal, perinatal and neonatal factors all contribute to the development of sinovenous thrombosis. It is important to identify these factors and, if necessary and possible, to start treatment. Anticoagulation therapy should be considered when sinovenous thrombosis is diagnosed. Long-term follow-up is needed in these children, as they run a substantial risk of developing postneonatal epilepsy (ESES) and of poorer developmental outcomes.

Probable association of tachyarrhythmia with nebulized albuterol in a child with previously subclinical wolff Parkinson white syndrome.

We present the case of a 2-year-old asthmatic boy with atrioventricular (AV)-reentry tachycardia following albuterol inhalation, who was later diagnosed with Wolff-Parkinson-White (WPW) syndrome. The Naranjo adverse drug reaction probability scale score for this adverse event was 7, indicating that the association between his AV-reentry tachycardia and inhalation of albuterol is probable. To our knowledge, this is the first case report that shows the potential arrhythmogenic effects of albuterol in a child with WPW syndrome. We urge clinicians to be aware of this potentially life-threatening adverse effect and to closely monitor these patients when they need beta-adrenergic drugs in case of emergency. Furthermore, this report highlights the dilemma regarding the safe treatment of pediatric patients with both asthma and WPW syndrome.

Inverse relationship between birth weight and blood pressure in growth-retarded but not in appropriate for gestational age infants during the first week of life.

BACKGROUND: Various studies have shown an association between low birth weight and the prevalence of elevated blood pressure later in life. However, a relationship between birth weight and blood pressure in the neonatal period has not been investigated yet. OBJECTIVE: To study the relationship between birth weight and blood pressure during the first week of life. METHODS: Systolic blood pressure (SBP), diastolic blood pressure (DBP) and mean arterial blood pressure (MBP) were measured every 8 h during days 1, 2, 3, 4 and 7 in 44 small for gestational age (SGA) infants and compared with those of infants born with a birth weight appropriate for gestational age (AGA). The infants were matched for gestational age and gender. RESULTS: Meanbirth weight (range) in the SGA group was 778 (460-1,400) g versus 1,524 (960-2,730) g in the AGA group, and mean (range) gestational age of both groups was 30.5 (27.3-35.5) weeks. In the first week of life, SGA and AGA infants had similar SBP, DBP and MBP. Also, after adjustment for confounders (maternal medication, smoking), SBP, DBP and MBP rose equally in SGA and AGA infants during the first week of life. AGA infants showed a positive correlation between birth weight and blood pressure, but SGA infants showed an inverse correlation. CONCLUSIONS: Although differences in blood pressure were found between SGA and AGA infants in the first week of life, the inverse relationship between birth weight and blood pressure in SGA infants warrants follow-up studies to investigate a possible link with late cardiovascular disease.

Disturbance of cerebral neuronal migration following congenital parvovirus B19 infection.

OBJECTIVE: We describe the clinical course of an infant who presented with severe fetal anemia and fetal hydrops following congenital parvovirus B19 infection before 16 gestational weeks. The fetus was treated by cordocentesis and intrauterine transfusion at 18 weeks. RESULTS: The infant demonstrated mild unilateral ventriculomegaly on antenatal magnetic resonance imaging, and polymicrogyria and heterotopia on postnatal magnetic resonance imaging. CONCLUSION: This adds to the evidence in recent literature of central nervous system damage associated with congenital parvovirus B19 infection.