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1.
Sci Rep ; 12(1): 21668, 2022 12 15.
Article in English | MEDLINE | ID: mdl-36522442

ABSTRACT

Sense of time is a complex construct, and its neural correlates remain to date in most part unknown. To complicate the frame, physical attributes of the stimulus, such as its intensity or movement, influence temporal perception. Although previous studies have shown that time perception can be compromised after a brain lesion, the evidence on the role of the left and right hemispheres are meager. In two experiments, the study explores the ability of temporal estimation of multi-second actions and non-biological movements in 33 patients suffering from unilateral brain lesion. Furthermore, the modulatory role of induced embodiment processes is investigated. The results reveal a joint contribution of the two hemispheres depending not only on different durations but also on the presence of actions. Indeed, the left hemisphere damaged patients find it difficult to estimate 4500 ms or longer durations, while the right hemisphere damaged patients fail in 3000 ms durations. Furthermore, the former fail when a biological action is shown, while the latter fail in non-biological movement. Embodiment processes have a modulatory effect only after right hemisphere lesions. Among neuropsychological variables, only spatial neglect influences estimation of non-biological movement.


Subject(s)
Brain Injuries , Perceptual Disorders , Humans , Functional Laterality , Psychomotor Performance , Judgment , Perceptual Disorders/etiology , Perceptual Disorders/psychology , Brain Injuries/complications , Brain , Neuropsychological Tests
2.
Neurol Sci ; 39(1): 135-139, 2018 Jan.
Article in English | MEDLINE | ID: mdl-29086123

ABSTRACT

The needs of community-dwelling stroke patients are often not fully addressed. The Global Stroke Community Advisory Panel had developed the Post Stroke Checklist (PSC) with the aim of standardizing long-term stroke assessment and consequently care of patients. PSC has been validated for UK and Singapore, and an Italian version has been proposed. The aim of this study is to assess the needs of community-dwelling Italian stroke patients using an online version of PSC. Secondary aim is to assess utility of PSC for patients and clinicians. The PSC was administered to a sample of 64 patients with stroke in Italy by general practioners. PSC is a questionnaire formed by 11 questions, each one covering a domain identified as important for patients' health. After administration of PSC, patient and clinician satisfaction with the PSC was assessed by a specific questionnaire. The PSC identified specific problems for patients related to a worsening from the last examination not evaluated by any specialist. The online PSC highlighted problems related to mood, (in 50% of sample), mobility (53.1%), spasticity (42.2%), and pain (37.5%). Both patients and clinicians provided good results about the utility of online PSC. The PSC was confirmed to be a useful tool for identifying the needs of community-dwelling patients with stroke. Particular attention should be deserved to problems related to mood, mobility, and hence participation to social life, pain, and spasticity. For taking into account these aspects, the online PSC can be a useful portable tool for clinicians.


Subject(s)
Checklist/standards , Primary Health Care/standards , Stroke Rehabilitation/standards , Stroke/diagnosis , Aged , Female , Humans , Italy , Male , Middle Aged , Needs Assessment , Patient Satisfaction
4.
Minerva Med ; 106(5): 287-307, 2015 Oct.
Article in English | MEDLINE | ID: mdl-26505839

ABSTRACT

Gait disorders are common and very disabling in elderly people, leading to an increase of risk of falling and reductions in quality of life. So far, many clinical classifications of gait disorders in the elderly population have been proposed. Here we suggest a novel categorization of gait disorders in elderly people, which takes into account the several resources required during gait. The biomechanical constraints, movement and sensory strategies, orientation in space, control of dynamics and cognitive processing are essential to perform safely gait. Moreover, the strictly connection between gait and balance has been discussed. According to this perspective, a literature search was performed including studies investigating the rehabilitation procedures in the management of balance and gait disorders in elderly people. Training aimed at improving muscle strength and flexibility, movement strategies, sensorimotor integration and sensory reweighting processes, balance in static and dynamic conditions and cognitive strategies have been proposed as possible therapeutic approaches in elderly people affected by gait disorders. Moreover, the role of new technological devices in improving balance and gait control has been also described. A multidisciplinary and interdisciplinary approach is fundamental for the management of gait disorders in elderly people. Rehabilitation procedures should take into consideration all the potential constraints involved in gait disorders in order to select the most appropriate intervention.

6.
Eur J Phys Rehabil Med ; 50(5): 525-33, 2014 Oct.
Article in English | MEDLINE | ID: mdl-24963604

ABSTRACT

BACKGROUND: Spasticity is a common disabling symptom of several neurological conditions including stroke. Botulinum toxin type A (BTX-A) injection represents the gold standard therapy for focal spasticity. Post-stroke management of patients receiving BTX-A therapy has been variously investigated, but general agreement on how and when to implement rehabilitation is lacking. AIM: To perform a national survey of experts on the most appropriate rehabilitation procedures after BTX-A therapy for the focal treatment of spasticity. DESIGN: The study employed the Delphi technique through the COSMO project (Consensus on Post-Injection Management in Post-stroke Spasticity). METHODS: Italian neurologists and physiatrists with experience in BTX-A therapy were selected to participate in the survey. Their anonymous opinions on key issues in treatment strategies in post-stroke spasticity were collected in three sequential rounds facilitated by a web platform. Consensus on a given issue was defined as agreed opinion by at least 66% of the survey participants. RESULTS: In all, 44 Italian experts were involved. Positive consensus was reached on the need to start rehabilitation during the first week after BTX-A injection therapy, with a rehabilitation program comprising both stretching combined with electrical stimulation and exercise therapy. Functional surgery may be considered only after 12-24 months in cases of BTX-A therapy failure. The use of commercial or custom-made orthoses in selected cases was recommended. The appropriate time interval between two BTX-A injections is 3-6 months, and clinical assessment should be performed 1 month after injection. CONCLUSION: The results of this national survey confirm that clinical experts on the use of BTX-A therapy for spasticity after stroke agree on the need to initiate rehabilitation treatment immediately after BTX-A injection: muscle stretching exercises, eventually combined with neuromuscular electrical stimulation, may enhance the effect of BTX-A therapy. Outcome after BTX-A therapy should be assessed at repeated follow-up visits. CLINICAL REHABILITATION IMPACT: This expert panel survey can provide guidance for clinicians in the assessment of patients treated with BTX-A therapy.


Subject(s)
Botulinum Toxins, Type A/therapeutic use , Muscle Spasticity/drug therapy , Neuromuscular Agents/therapeutic use , Stroke Rehabilitation , Attitude of Health Personnel , Delphi Technique , Disease Management , Humans , Italy , Muscle Spasticity/etiology , Muscle Spasticity/rehabilitation , Practice Patterns, Physicians' , Stroke/complications
7.
Eur J Phys Rehabil Med ; 50(5): 489-94, 2014 Oct.
Article in English | MEDLINE | ID: mdl-24346154

ABSTRACT

BACKGROUND: The degree of initial paresis relates to spasticity development in stroke patients. However, the importance of proximal and distal paresis in predicting spasticity after stroke is unclear. AIM: To investigate the role of topical distribution of initial limb paresis to predict clinically relevant spasticity in adults with stroke. DESIGN: Retrospective cohort study METHODS: Seventy-two first-ever ischemic stroke patients were examined. At the acute phase of illness, demographics and the European Stroke Scale motor items (maintenance of outstretched arm position, arm raising, wrist extension, grip strength, maintenance of outstretched leg position, leg flexion, foot dorsiflexion) were evaluated. At six months after the stroke onset, spasticity was assessed at the upper and lower limb with the modified Ashworth Scale. Clinically relevant spasticity was defined as modified Ashworth Scale ≥3 (0-5). RESULTS: The degree of initial paresis of the proximal muscles of the upper limb and the distal muscles of the lower limb showed the strongest association and the best profile of sensitivity-specificity in predicting clinically relevant spasticity at the upper and lower limb, respectively. Younger age showed higher risk for developing clinically relevant spasticity in the upper limb. CONCLUSIONS: Our findings support the hypothesis that the initial degree of proximal paresis of the upper limb and distal paresis of the lower limb as well as age may be considered early predictors of clinically relevant spasticity in adults with ischemic stroke. CLINICAL REHABILITATION IMPACT: Our findings further improve the role of initial paresis as predictor of spasticity after stroke.


Subject(s)
Brain Ischemia/complications , Lower Extremity , Muscle Spasticity/etiology , Paresis/diagnosis , Stroke/complications , Upper Extremity , Age Factors , Aged , Aged, 80 and over , Brain Ischemia/diagnosis , Female , Humans , Male , Middle Aged , Paresis/complications , Point-of-Care Systems , Predictive Value of Tests , Prognosis , Retrospective Studies , Risk Factors , Stroke/diagnosis
8.
Eur J Phys Rehabil Med ; 48(3): 483-506, 2012 Sep.
Article in English | MEDLINE | ID: mdl-23075907

ABSTRACT

Management of brachial plexus injury sequelae is a challenging issue in neurorehabilitation. In the last decades great strides have been made in the areas of early diagnosis and surgical techniques. Conversely, rehabilitation of brachial plexus injury is a relatively unexplored field. Some critical aspects regarding brachial plexus injury rehabilitation have to be acknowledged. First, brachial plexus injury may result in severe and chronic impairments in both adults and children, thus requiring an early and long-lasting treatment. Second, nerve damage causes a multifaceted clinical picture consisting of sensorimotor disturbances (pain, muscle atrophy, muscle weakness, secondary deformities) as well as reorganization of the Central Nervous System that may be associated with upper limb underuse, even in case of peripheral injured nerves repair. Finally, psychological problems and a lack of cooperation by the patient may limit rehabilitation effects and increase disability. In the present paper the literature concerning brachial plexus injury deficits and rehabilitation in both adults and children was reviewed and discussed. Although further research in this field is recommended, current evidence supports the potential role of rehabilitation in reducing both early and long-lasting disability. Furthermore, the complexity of the functional impairment necessitates an interdisciplinary approach incorporating various health professionals in order to optimizing outcomes.


Subject(s)
Brachial Plexus Neuropathies/rehabilitation , Brachial Plexus/injuries , Disability Evaluation , Rehabilitation Centers , Adult , Child , Humans
9.
Eur J Phys Rehabil Med ; 48(1): 147-53, 2012 Mar.
Article in English | MEDLINE | ID: mdl-22543558

ABSTRACT

BACKGROUND: Gait training with the help of assistive technological devices is an innovative field of research in neurological rehabilitation. Most of the available gait training devices do not allow free movement in the environment, which would be the most suitable natural and motivating condition for training children with neurological gait impairment. AIM: To evaluate the potential applicability of a new robotic walking aid as a tool for gait training in non-ambulatory children with Cerebral Palsy. DESIGN: Single case study SETTING: Outpatient regimen POPULATION: A 11-years-old child unable to stand and walk independently as a result of spastic tetraplegic cerebral palsy (CP). METHODS: The experimental device was a newly actuated version of a dynamic combined walking and standing aid (NF-Walker®) available in the market which was modified by means of two pneumatic artificial muscles driven by a foot-switch inserted in the shoes. The child was tested at baseline (while maintaining the standing position aided by the non-actuated NF-Walker®) and in the experimental condition (while using the actuated robotic aid). The outcome measures were: 2-minute walking test, 10-metre walking test, respiratory and heart parameters, energy cost of locomotion. RESULTS: At baseline, the child was unable to perform any autonomous form of locomotion. When assisted by the actuated aid (i.e. during the experimental condition), the child was successful in moving around in his environment. His performance was 19.63 m in the 2-minute walking test and 64 s in the 10-metre walking test. Respiratory and heart parameters were higher than healthy age-matched children both at baseline and in the experimental condition. The energy cost of gait, which was not valuable in the baseline condition, was significantly higher than normality during the experimental condition. CONCLUSION: The new robotic walking aid may help children suffering from CP with severe impairment of gait to move around in their environment. CLINICAL REHABILITATION IMPACT: This new robotic walking device may have a potential impact in stimulating the development and in training of gait in children with neurological gait impairment. Future studies are warranted in order to test this hypothesis.


Subject(s)
Cerebral Palsy/rehabilitation , Exercise Therapy/instrumentation , Robotics/instrumentation , Self-Help Devices , Walkers , Walking/physiology , Cerebral Palsy/physiopathology , Child , Equipment Design , Follow-Up Studies , Gait/physiology , Humans , Male
10.
Eur J Phys Rehabil Med ; 48(2): 189-96, 2012 Jun.
Article in English | MEDLINE | ID: mdl-22083263

ABSTRACT

BACKGROUND: It has been well established that the presence of neglect is a predictor of poor functional outcome after stroke. Most rehabilitation studies on neglect have been performed with at least two months post-stroke. However, a recent series of stroke management indications highlight the importance of early rehabilitation treatment and evidence regarding neglect rehabilitation in the early phase after stroke is needed. AIM: To evaluate the effectiveness of right half-field patches in treating neglect in patients during the early phase of stroke. DESIGN: Randomized controlled trial. SETTING: Acute care setting in an urban general hospital. POPULATION: Eighteen patients with left unilateral neglect recruited among 56 patients consecutively admitted with right hemispheric stroke. METHODS: The patients were evaluated at pre-treatment, post-treatment, and at a 7-day follow-up. The experimental group received right half-field patch treatment (n=10) for approximately 8 hours a day for 15 consecutive days. The control group received visual scanning training (n=8) for 40 minutes every weekday in a 15 day period. RESULTS: Both groups significantly improved their performance in all outcome measures. No difference in the amount of improvement between the two groups was found. CONCLUSION: Right half-field eye patching could be a promising technique for treating visual spatial neglect during the early stages of stroke. CLINICAL REHABILITATION IMPACT: The eye-patching technique may represent an easily applicable and inexpensive method for neglect rehabilitation in the early stage after stroke.


Subject(s)
Functional Laterality , Perceptual Disorders/rehabilitation , Sensory Deprivation , Stroke Rehabilitation , Visual Perception , Aged , Aged, 80 and over , Female , Follow-Up Studies , Humans , Male , Middle Aged , Perceptual Disorders/etiology , Perceptual Disorders/physiopathology , Retrospective Studies , Single-Blind Method , Stroke/complications , Stroke/physiopathology , Treatment Outcome
11.
Eur J Phys Rehabil Med ; 47(4): 561-8, 2011 Dec.
Article in English | MEDLINE | ID: mdl-21796089

ABSTRACT

BACKGROUND: Whiplash associated disorders commonly affect people after a motor vehicle accident, causing a variety of disabling manifestations. Some manual and physical approaches have been proposed to improve myofascial function after traumatic injuries, in order to effectively reduce pain and functional limitation. AIM: To evaluate whether the application of the Fascial Manipulation© technique could be more effective than a conventional approach to improve cervical range of motion in patients with subacute whiplash associated disorders. DESIGN: Pilot randomized clinical trial. METHODS: Eighteen patients with subacute whiplash associated disorders were randomized into two groups. Group A (N.=9) received three, 30-minute sessions, (every five days during a two week period) of neck Fascial Manipulation©. Group B (N.=9) received ten, 30-minute sessions (five days a week for two consecutive weeks) of neck exercises plus mobilization. Patients were evaluated before, immediately after and two weeks post-treatment. PRIMARY OUTCOME MEASURES: cervical active range of motion (flexion, extension, right lateral-flexion, left lateral-flexion, right rotation, and left rotation). RESULTS: A statistically significant improvement in neck flexion was found after treatment in favour of Group A (60.2±10.8°) compared with Group B (46.3±15.1°). No differences were found between groups for the other primary outcomes at post-treatment or follow-up. CONCLUSION: The Fascial Manipulation© technique may be a promising method to improve cervical range of motion in patients with subacute whiplash associated disorders. CLINICAL REHABILITATION IMPACT: Myofascial techniques may be useful for improving treatment of subacute whiplash associated disorders also reducing their economic burden.


Subject(s)
Fascia/physiology , Manipulation, Spinal/methods , Neck Pain/rehabilitation , Whiplash Injuries/rehabilitation , Adult , Cervical Vertebrae/physiology , Female , Humans , Italy , Male , Middle Aged , Neck Pain/etiology , Neck Pain/physiopathology , Outcome Assessment, Health Care , Outpatients , Pilot Projects , Range of Motion, Articular/physiology , Statistics, Nonparametric , Whiplash Injuries/complications , Whiplash Injuries/physiopathology , Young Adult
12.
Eur J Phys Rehabil Med ; 47(3): 435-40, 2011 Sep.
Article in English | MEDLINE | ID: mdl-21460790

ABSTRACT

BACKGROUND: Lower limb paresis is one of the main determinants of postural transferring, standing and walking disability in patients with stroke. Early prognosis of recovery of lower limb function and of related functional disability is an important issue in neurorehabilitation clinical practice. AIM: Aim of this study was to assess the relationship between active ankle dorsiflexion and the Mingazzini manoeuvre with the prognosis of lower limb function and of postural transferring, standing and walking ability in patients with stroke. DESIGN: This was a longitudinal study with prospectively collected data. SETTING: University hospital. POPULATION: The study included 53 patients with first unilateral brain ischemic stroke. METHODS: Patients were evaluated initially (mean 4.02 days) and approximately at six months (mean 178.6 days) after stroke. Initial assessment included active ankle dorsiflexion and the Mingazzini manoeuvre. The assessment after six months included three outcome measures evaluating the rate of improvement of lower limb function and of postural transferring, standing and walking ability (Postural Assessment Scale for Stroke patients, Functional Ambulation Category, Motricity Index leg subtest). RESULTS: The active ankle dorsiflexion showed to be related with the prognosis of lower limb function and of walking ability, while the Mingazzini manoeuvre was related with the improvement of postural transferring and standing ability. CONCLUSION: Active ankle dorsiflexion and the Mingazzini manoeuvre are related with the prognosis of lower limb function and of postural transferring, standing and walking ability in patients with stroke. CLINICAL REHABILITATION IMPACT: These simple bedside tests give a picture of improvement potential of motor activities connected to lower limb function in patients with acute stroke.


Subject(s)
Ankle Joint/physiopathology , Posture/physiology , Stroke Rehabilitation , Stroke/physiopathology , Walking/physiology , Aged , Female , Humans , Linear Models , Longitudinal Studies , Male , Predictive Value of Tests , Prognosis , Prospective Studies , Treatment Outcome
13.
Eur J Phys Rehabil Med ; 46(3): 423-38, 2010 Sep.
Article in English | MEDLINE | ID: mdl-20927008

ABSTRACT

Spasticity is a major disabling symptom in many patients with spinal and/or cerebral lesions. During functional movements, spasticity manifests itself within the complex condition of the "spastic movement disorder". The pathophysiology of the spastic movement disorder relies on multiple factors including abnormal supraspinal drive, abnormal control of reflex activities, and changes in muscle mechanical properties. The most widely used procedures for management of spasticity are represented by pharmacological treatment aimed at inhibiting reflex hyperexcitability. In the last decades, several non pharmacological procedures for treating spasticity have been put forward, including muscle stretching, muscle reinforcement, physical agents and pain management. These procedures may have both neurophysiological and biomechanical effects on the spastic movement disorder. In the present paper, the literature concerning non-pharmacological procedures in the treatment of spasticity was reviewed and discussed, taking into account the multifaceted pathophysiology of the spastic movement disorder. Although further research in this field is recommended, existing evidence supports the potential role of rehabilitation interventions as a therapeutic tool, which could be integrated with traditional pharmacological procedures in the management of the spastic movement disorder.


Subject(s)
Muscle Spasticity/rehabilitation , Muscle Stretching Exercises , Resistance Training , Biofeedback, Psychology/methods , Electric Stimulation Therapy , Humans , Muscle Spasticity/physiopathology , Pain/etiology , Pain/physiopathology , Pain Management , Short-Wave Therapy , Ultrasonic Therapy
14.
Eur J Phys Rehabil Med ; 45(4): 493-500, 2009 Dec.
Article in English | MEDLINE | ID: mdl-20032907

ABSTRACT

AIM: Constraint-induced movement therapy (CIT) is a rehabilitation intervention put forward by Taub and colleagues for sensorimotor disorders in children with hemiparesis, comprising consisting of the restraint of the unaffected arm and concurrent intensive training of the affected arm for six hours/day for two weeks. The aim of this study was to evaluate the effectiveness of a modified CIT program (mCIT) characterized by restraining the unaffected hand with a cotton mitten during daily activities and a reduced intensity training program for two h/week for five weeks. METHODS: Ten children (age: 1-9 years) with hemiparetic cerebral palsy were enrolled in a randomized, cross-over study in which the effects of a mCIT and a conventional physiotherapy program were compared. The amount of use and the functional performance of the affected arm were evaluated by means of two specifically devised tests (Use and Function Test). A further test evaluated functional performance during bimanual tasks. These measures showed a good inter-rater and inter-session reliability. All tests were administered before, at the end and four weeks after treatment. RESULTS: Significant differences between the two therapeutic approaches were evidenced in both affected arm use (P=0.008) and function (P=0.018). These improvements maintained at the follow-up (Use Test P=0.07; paretic arm function P=0.012). Bimanual function performance showed a trend towards improvement in both post-treatment and follow-up testing. The conventional physiotherapy group did not show any improvement in any outcome measure. CONCLUSIONS: The mCIT program proposed in the present study showed to be a promising rehabilitative procedure in children with congenital arm paresis after cerebral palsy.


Subject(s)
Activities of Daily Living , Cerebral Palsy/rehabilitation , Exercise Therapy/methods , Paresis/rehabilitation , Restraint, Physical , Cerebral Palsy/complications , Cerebral Palsy/physiopathology , Child , Child, Preschool , Cross-Over Studies , Follow-Up Studies , Hand , Humans , Infant , Paresis/etiology , Paresis/physiopathology , Recovery of Function , Treatment Outcome
15.
Eur J Phys Rehabil Med ; 45(3): 349-54, 2009 Sep.
Article in English | MEDLINE | ID: mdl-19396056

ABSTRACT

AIM: The level of daily life autonomy in patients with stroke may be related to recovery of affected arm function. The aim of the study was to assess whether four simple bedside indexes of arm recovery can predict levels of autonomy in daily life activities. METHODS: A consecutive sample of 48 patients presenting with upper limb paresis/plegia in the acute stage after stroke was selected. Patients underwent five evaluation sessions at 7, 14, 30, 90 and 180 days after stroke. Forward stepwise multiple regression analysis was used to clarify the role of four potential predictors of upper limb recovery (active finger extension, shoulder abduction, shoulder shrug and hand movement scales). Dependent variables in these models were the Barthel Index score and sub-items of the Burke-Fahn-Marsden Scale. RESULTS: The active finger extension scale showed a highly significant statistical correlation with patient performance in nearly all outcome measures. The shoulder shrug correlated with the BI score, and with the dressing and hygiene Burke-Fahn-Marsden Scale sub-items. Shoulder abduction and hand movement scale played only a minor role. CONCLUSIONS: The active finger extension scale proved to be a strong early predictor of recovery of daily life autonomy in patients with stroke. This finding could be important in order to planning a specific rehabilitation treatment after the onset.


Subject(s)
Activities of Daily Living , Arm/physiopathology , Recovery of Function , Stroke/physiopathology , Adult , Aged , Aged, 80 and over , Disability Evaluation , Female , Humans , Male , Middle Aged , Outcome Assessment, Health Care , Prognosis , Stroke Rehabilitation
16.
Neurorehabil Neural Repair ; 22(4): 396-403, 2008.
Article in English | MEDLINE | ID: mdl-18326890

ABSTRACT

BACKGROUND: Functional neuroimaging studies show adaptive changes in areas adjacent and distant from the stroke. This longitudinal study assessed whether changes in cortical excitability in affected and unaffected motor areas after acute stroke correlates with functional and motor recovery. METHODS: We studied 13 patients with moderate to severe hemiparesis 5 to 7 days (T1), 30 days (T2), and 90 days (T3) after acute unilateral stroke, as well as 10 healthy controls. We used paired-pulse transcranial magnetic stimulation to study intracortical inhibition and facilitation, recording from the bilateral thenar eminences. F waves were also recorded. RESULTS: At T1, all patients showed significantly reduced intracortical inhibition in the unaffected hemisphere. At T2, in patients whose motor function recovered, intracortical inhibition in the unaffected hemisphere returned to normal. In patients with poor clinical motor recovery, abnormal disinhibition persisted in both hemispheres. At T3, in patients whose motor function progressively recovered, the abnormal disinhibition in the unaffected hemisphere decreased further, whereas in patients whose motor function remained poor, abnormal inhibition in the unaffected hemisphere persisted. No modification of F-wave latency and amplitude were found in patients and controls. CONCLUSIONS: During early days after stroke, motor cortical disinhibition involves both cerebral hemispheres. Longitudinal changes in motor disinhibition of the unaffected hemisphere may reflect the degree of clinical motor recovery.


Subject(s)
Motor Cortex/physiopathology , Neural Inhibition , Neuronal Plasticity , Recovery of Function , Stroke Rehabilitation , Stroke/physiopathology , Adaptation, Physiological/physiology , Aged , Brain Mapping , Evoked Potentials, Motor/physiology , Female , Functional Laterality/physiology , Humans , Male , Middle Aged , Neural Inhibition/physiology , Neural Pathways/physiopathology , Neuronal Plasticity/physiology , Paresis/etiology , Paresis/physiopathology , Paresis/rehabilitation , Recovery of Function/physiology , Time Factors , Transcranial Magnetic Stimulation
17.
Neurology ; 67(11): 2050-2, 2006 Dec 12.
Article in English | MEDLINE | ID: mdl-17159119

ABSTRACT

We randomly assigned 33 patients with left hemisphere stroke, limb apraxia, and aphasia to an apraxia or a control (aphasia) treatment group. Before and after each treatment, patients underwent a comprehensive neuropsychological testing battery and a caregiver evaluation of patient's activities of daily life (ADL) independence. Apraxia severity was related with ADL independence. Control (aphasia) treatment improved patients' language and intelligence performance. Apraxia treatment specifically improved praxic function and ADL.


Subject(s)
Activities of Daily Living , Apraxias/rehabilitation , Stroke Rehabilitation , Adult , Aged , Aphasia/complications , Aphasia/rehabilitation , Apraxias/complications , Extremities/physiopathology , Female , Follow-Up Studies , Humans , Male , Middle Aged , Stroke/complications
19.
J Neurol Neurosurg Psychiatry ; 77(7): 822-5, 2006 Jul.
Article in English | MEDLINE | ID: mdl-16549416

ABSTRACT

AIMS: To study the association of pain with motor complications in 117 patients with Parkinson's disease. METHODS: Patients were asked to refer any pain they experienced at the time of study and lasting since at least 2 months. Basic parkinsonian signs and motor complications (including motor fluctuations and dyskinesia) were assessed and Unified Parkinson's Disease Rating Scale (UPDRS) motor score part III (during on) and part IV were calculated. Information on age, sex, duration of disease, use of dopamine agonists and levodopa, years of levodopa treatment and current levodopa dosage, medical conditions possibly associated with pain, and depression were collected. Single and multiple explanatory variable logistic regression models were used to check the association of pain with the investigated variables. RESULTS: Pain was described by 47 patients (40%) and could be classified into dystonic (n.19) and non dystonic pain (n.16); in 12 patients both types coexisted. Multiple explanatory variable logistic regression models indicated a significant association of pain with motor complications (adjusted OR, 5.7; 95% CI, 2 to 16.5; p = 0.001). No association was found between pain, dystonic or non dystonic, and the other investigated variables including medical conditions known to be associated to pain in the general population. There was a significant correlation (r = 0.31, p<0.05) between severity of pain (measured on a Visual Analogue Scale) and severity of motor complications (UPDRS part IV). CONCLUSIONS: Pain may be a representative feature of Parkinson's disease frequently associated with motor complications. The association is independent of a number of potentially relevant demographic and clinical variables.


Subject(s)
Motor Skills Disorders/etiology , Pain/etiology , Parkinson Disease/complications , Aged , Female , Humans , Male , Middle Aged , Pain Measurement , Parkinson Disease/drug therapy , Severity of Illness Index
20.
Neurol Sci ; 27(6): 397-401, 2006 Dec.
Article in English | MEDLINE | ID: mdl-17205224

ABSTRACT

We used qualitative visual assessment and semiquantitative measures of striatal DAT binding using [(123)I]FP-CIT-SPET in 85 patients with Parkinson's disease (PD). We compared these two assessments and their correlation with PD clinical progression. SPET imaging was visually classified by a nuclear medicine physician as normal or abnormal pattern grade I, II and III, in relation to a different degree of radioligand reduction uptake. Nineteen patients presented abnormal grade I (group 1), 53 grade II (group 2) and 13 grade III (group 3). The UPDRS III motor score, the H-Y score, the rigidity and bradykinesia subscores were significantly different among the three groups. Post hoc analysis showed that all values of these clinical parameters were higher in group 3 than in 2 and 1. All clinical indices were also significantly higher in group 2 than in group 1. This means that groups 3 and 2 were clinically more severely affected. No significant differences among the 3 groups were observed for age or duration of disease. Values of the mean striatum uptake were also significantly different among the three groups. Post hoc analysis revealed significantly lower values of the mean striatum uptake in group 3 with respect to groups 2 and 1; values were also significantly lower in group 2 than in group 1. We conclude that our findings of good consistency between visual and semi-quantitative assessment may help simplify the evaluation of striatal DAT binding in PD in a clinical routine setting.


Subject(s)
Corpus Striatum/diagnostic imaging , Parkinson Disease/diagnostic imaging , Tomography, Emission-Computed, Single-Photon/methods , Tropanes , Aged , Corpus Striatum/metabolism , Dopamine Plasma Membrane Transport Proteins/metabolism , Female , Humans , Iodine Radioisotopes , Male , Middle Aged
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