ABSTRACT
From the aerial parts, pericarps and roots of Solenostemma argel, three new pregnane glycosides (1-3) with two known ones and a new phenolic glycoside (4) have been isolated. Their structures were established by extensive 1D - and 2D NMR and mass spectroscopic analysis. The cytotoxicity of all compounds was evaluated against two human tumor cell lines (SW 480, MCF-7), but none of them was active in the concentration range 0.9-59.0µM. Compounds 2 and the known argeloside F at non toxic concentrations for the PBMCs (27.3µM and 27.6µM, respectively) significantly decreased the Il-1ß production by LPS-stimulated PBMCs. All isolated compounds showed a significant antioxidant potential with ORAC values in the concentration range 3481-9617µmoleq. Trolox/100g.
Subject(s)
Apocynaceae/chemistry , Glycosides/chemistry , Phenols/chemistry , Pregnanes/chemistry , Anti-Inflammatory Agents/chemistry , Anti-Inflammatory Agents/isolation & purification , Antineoplastic Agents, Phytogenic/chemistry , Antineoplastic Agents, Phytogenic/isolation & purification , Cell Line, Tumor , Glycosides/isolation & purification , Humans , Leukocytes, Mononuclear/drug effects , Molecular Structure , Phenols/isolation & purification , Plant Extracts/chemistry , Plant Roots/chemistry , Pregnanes/isolation & purificationABSTRACT
3beta-(3,4-Dihydroxycinnamoyl)-erythrodiol was isolated as the cytotoxic constituent of the roots of Zygophyllum geslini.
