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1.
Reg Anesth Pain Med ; 2024 Feb 21.
Article in English | MEDLINE | ID: mdl-38388017

ABSTRACT

BACKGROUND: Radiofrequency (RF) treatment of the genicular nerves reduces chronic knee pain in patients with osteoarthritis (OA) or persistent postsurgical pain (PPSP) after total knee arthroplasty (TKA). The objective of this study is to compare long-term outcomes of cooled and conventional RF and perform an economic evaluation. METHODS: The COCOGEN trial is a double-blinded, non-inferiority, pilot, randomized controlled trial that compared the effects up to 12 months of cooled and conventional RF in patients with chronic knee pain suffering from OA or PPSP after TKA following a 1:1 randomization rate. Outcomes were knee pain, functionality, quality of life, emotional health, medication use, and adverse events. A trial-based economic evaluation was performed with a 12-month societal perspective. Here, the primary outcome was the incremental costs per quality-adjusted life year (QALY). RESULTS: 41 of the 49 included patients completed the 12-month follow-up. One patient in the PPSP cooled RF group had substantial missing data at 12-month follow-up. The proportion of patients with ≥50% pain reduction at 12 months was 22.2% (4/18) in patients treated with conventional RF versus 22.7% (5/22) in patients treated with cooled RF (p>0.05). There was a statistically significant difference in the mean absolute numerical rating scale at 12 months after cooled RF and conventional RF in patients with PPSP (p=0.02). Differences between other outcomes were not statistically significant. The health economic analysis indicated that cooled RF resulted in lower costs and improved QALYs compared with conventional RF in PPSP but not in OA. There were no serious adverse events. CONCLUSIONS: Both RF treatments demonstrated in approximately 22% of patients a ≥50% pain reduction at 12 months. In patients with PPSP, contrary to OA, cooled RF seems to be more effective than conventional RF. Additionally, cooled RF has in patients with PPSP, as opposed to OA, greater effectiveness at lower costs compared with conventional RF. TRIAL REGISTRATION NUMBER: NCT03865849.

2.
Reg Anesth Pain Med ; 48(5): 197-204, 2023 05.
Article in English | MEDLINE | ID: mdl-36653065

ABSTRACT

BACKGROUND: Radiofrequency (RF) treatment of the genicular nerves has the potential to reduce chronic knee pain due to osteoarthritis or persistent postsurgical pain, however, a direct comparison between the two main modalities used, conventional and cooled, is lacking. METHODS: This double blind, non-inferiority, pilot, randomized controlled trial compared the effects of cooled and conventional RF in chronic knee pain patients suffering from osteoarthritis or persistent postsurgical pain after total knee arthroplasty. Patients were randomized following a 1:1 rate. The primary outcome was the proportion of patients with ≥50% pain reduction at 3 months postintervention. Other outcomes were knee pain, functionality, quality of life, emotional health, and adverse events up to 6 months postintervention. Conventional RF treatment was tested for non-inferiority to cooled in reducing knee pain at 3 months follow-up. RESULTS: Forty-nine of 70 patients were included, of which 47 completed a 3-month follow-up. The primary outcome was achieved in 4 of 23 patients treated with conventional RF (17%) vs in 8 of 24 with cooled (33%) (p=0,21). Results from the non-inferiority comparison were inconclusive in relation to the non-inferiority margin. There was no statistically significant difference between secondary outcomes. There were no serious adverse events. CONCLUSIONS: Both conventional and cooled RF treatment reduced pain in the osteoarthritis and persistent postsurgical pain population. This pilot study did not demonstrate statistically significant differences in the proportion of patients experiencing ≥50% pain reduction between techniques. The non-inferiority analysis was inconclusive. These results warrant further research. TRIAL REGISTRATION NUMBER: NCT03865849.


Subject(s)
Osteoarthritis, Knee , Humans , Pilot Projects , Osteoarthritis, Knee/complications , Osteoarthritis, Knee/diagnosis , Osteoarthritis, Knee/surgery , Quality of Life , Pain Management/methods , Treatment Outcome , Pain, Postoperative/diagnosis , Pain, Postoperative/etiology , Pain, Postoperative/prevention & control
3.
Pain Pract ; 22(5): 541-546, 2022 06.
Article in English | MEDLINE | ID: mdl-35485298

ABSTRACT

BACKGROUND: Radiofrequency (RF) treatment of the genicular nerves offers pain relief in patients suffering from chronic knee pain including persistent post-surgical knee pain (PPSP). We present the first case report of the development of complex regional pain syndrome (CRPS) in a chronic knee pain patient after an RF ablation of the genicular nerves that was successfully treated with dorsal root ganglion (DRG) stimulation. CASE PRESENTATION: The patient developed increased pain, sympathetic and dysmorphic changes of the index knee 10 weeks after RF treatment for PPSP. Diagnosis of CRPS type II was made using positive clinical findings and the Budapest diagnostic tool. Laboratory workup and PET-CT were negative. The patient was refractory to usual care and she was treated successfully with dorsal ganglion root stimulation. CONCLUSIONS: Complex regional pain syndrome is a possible complication of RF ablation of the genicular nerves in patients with chronic knee pain, and DRG stimulation may be a treatment option. Physicians should be aware of this complication, especially when patients have a medical history of CRPS.


Subject(s)
Catheter Ablation/adverse effects , Complex Regional Pain Syndromes/therapy , Ganglia, Spinal/physiology , Osteoarthritis, Knee/complications , Transcutaneous Electric Nerve Stimulation , Arthralgia/etiology , Arthralgia/therapy , Complex Regional Pain Syndromes/etiology , Female , Ganglia, Spinal/diagnostic imaging , Humans , Pain/surgery , Positron Emission Tomography Computed Tomography
4.
Knee Surg Sports Traumatol Arthrosc ; 27(2): 611-617, 2019 Feb.
Article in English | MEDLINE | ID: mdl-30298415

ABSTRACT

PURPOSE: To assess the risk of femoral tunnel convergence in combined anterior cruciate ligament (ACL) and anterolateral ligament (ALL) reconstructions. The hypothesis was that a more proximal and anterior orientation of the ALL femoral tunnel should reduce the risk of convergence with the ACL femoral tunnel. METHODS: 15 fresh-frozen cadaver knees were examined. An anatomic ACL femoral tunnel was drilled arthroscopically in each specimen and ALL tunnels were made in two directions: (1) 0° coronal angulation and 20° axial angulation, (2) 30° coronal angulation and 30° axial angulation. Computed tomography scans were performed to investigate tunnel convergence and to measure the minimal distance between tunnels, tunnel length and the LFC width. RESULTS: Tunnel convergence occurred in 20 of 30 cases (67%). Convergence was significantly reduced when tunnels were drilled at 30° coronal and 30° axial angulation (p < 0.05). The mean length of the ALL tunnel was 15.9 mm [95% CI (13.6; 18.1)] and was independent of ALL tunnel angulation. The mean minimal distance between the ALL and ACL tunnel was 3.1 mm [95% CI (2.1; 4.1)]. The odds ratio for tunnel convergence was 3.5 for small LFC, relative to large LFC (n.s.) CONCLUSION: A high risk of tunnel convergence was observed when performing combined ACL and ALL reconstructions. The clinical relevance of this work is that the occurrence of tunnel conflicts can be reduced by aiming the ALL tunnel in a more proximal and anterior direction. Surgeons should be aware of this, since tunnel convergence could jeopardize the ACL reconstruction and fixation.


Subject(s)
Anterior Cruciate Ligament Injuries/surgery , Femur/surgery , Knee Joint/surgery , Aged , Aged, 80 and over , Anterior Cruciate Ligament Injuries/diagnostic imaging , Anterior Cruciate Ligament Reconstruction , Cadaver , Female , Humans , Male , Tomography, X-Ray Computed
5.
Knee ; 24(5): 949-956, 2017 Oct.
Article in English | MEDLINE | ID: mdl-28784565

ABSTRACT

BACKGROUND: The aim of this study was to provide a characterization of the tensile properties of the medial collateral ligament (MCL), lateral collateral ligament (LCL), anterolateral ligament (ALL) and medial patellofemoral ligament (MPFL). Our hypothesis was that extra-articular knee ligaments are heterogeneous in nature and possess distinct material properties. METHODS: MCL (n=12), LCL (n=11), MPFL (n=12) and ALL (n=19) samples from fresh frozen human cadaveric knees were subjected to uniaxial tensile testing to failure and analyzed for their material properties. The elastic modulus (slope of the linear portion of the stress/strain curve), ultimate stress (stress at failure), ultimate strain (strain at failure) and strain energy density (area under the stress/strain curve) were calculated. RESULTS: The MCL had the highest elastic modulus (441.8±117.2MPa) and was significantly greater than the MPFL (294.6±190.4MPa) and LCL (289.0±159.7MPa) (P<0.05) as well as the ALL (173.7±91.8MPa) (P<0.001). The ultimate stress was significantly higher (P<0.05) for the LCL (83.6±38.1MPa) and MCL (72.4±20.7MPa), relative to the MPFL (49.1±31.0MPa) and ALL (46.4±20.1MPa). The ultimate strain of the LCL (41.0±9.9%) and ALL (37.8±7.9%) were significantly higher (P<0.05) compared to the MCL (22.9±2.5%) and MPFL (22.2±5.6%). The strain energy density of the LCL (15.2±6.4MPa) was significantly greater (P<0.05) than all other ligaments (ALL 7.8±3.1MPa, MCL 7.5±2.9MPa and MPFL 5.0±2.9MPa). CONCLUSIONS: Extra-articular knee ligaments are a heterogeneous group with respect to material characteristics. Each ligament has tensile properties that are significantly different from others and treatment strategies should take these findings into account.


Subject(s)
Knee Joint/physiology , Ligaments, Articular/physiology , Aged , Aged, 80 and over , Biomechanical Phenomena , Cadaver , Collateral Ligaments/physiology , Elastic Modulus , Elasticity , Female , Humans , Male , Stress, Mechanical , Tensile Strength
6.
Knee ; 24(5): 957-964, 2017 Oct.
Article in English | MEDLINE | ID: mdl-28789872

ABSTRACT

OBJECTIVES: The aim of this study was to provide information about the mechanical properties of grafts used for knee ligament reconstructions and to compare those results with the mechanical properties of native knee ligaments. METHODS: Eleven cadaveric knees were dissected for the semitendinosus, gracilis, iliotibial band (ITB), quadriceps and patellar tendon. Uniaxial testing to failure was performed using a standardized method and mechanical properties (elastic modulus, ultimate stress, ultimate strain, strain energy density) were determined. RESULTS: The elastic modulus of the gracilis tendon (1458±476MPa) (P<0.001) and the semitendinosus tendon (1036±312MPa) (P<0.05) was significantly higher than the ITB (610±171MPa), quadriceps tendon (568±194MPa), and patellar tendon (417±107MPa). In addition, the ultimate stress of the hamstring tendons (gracilis 155.0±30.7MPa and semitendinosus 120.1±30.0MPa) was significantly higher (P<0.001, respectively P<0.05), relative to the ITB (75.0±11.8MPa), quadriceps tendon (81.0±27.6MPa), and patellar tendon (76.2±25.1MPa). A significant difference (P<0.05) could be noticed between the ultimate strain of the patellar tendon (24.6±5.9%) and the hamstrings (gracilis 14.5±3.1% and semitendinosus 17.0±4.0%). No significant difference in strain energy density between the grafts was observed. CONCLUSIONS: Material properties of common grafts used for knee ligament reconstructions often differ significantly from the original knee ligament which the graft is supposed to emulate.


Subject(s)
Knee Joint/physiology , Ligaments, Articular/physiology , Tendons/physiology , Tendons/transplantation , Aged , Aged, 80 and over , Autografts/physiology , Biomechanical Phenomena , Cadaver , Elastic Modulus , Gracilis Muscle/physiology , Gracilis Muscle/transplantation , Hamstring Tendons/physiology , Hamstring Tendons/transplantation , Humans , Middle Aged , Patellar Ligament/physiology , Patellar Ligament/transplantation , Quadriceps Muscle/physiology , Quadriceps Muscle/transplantation , Plastic Surgery Procedures , Thigh
7.
Arthroscopy ; 33(5): 1028-1035.e1, 2017 May.
Article in English | MEDLINE | ID: mdl-28359668

ABSTRACT

PURPOSE: To characterize the tensile and histologic properties of the anterolateral ligament (ALL), inferior glenohumeral ligament (IGHL), and knee capsule. METHODS: Standardized samples of the ALL (n = 19), anterolateral knee capsule (n = 15), and IGHL (n = 13) were isolated from fresh-frozen human cadavers for uniaxial tensile testing to failure. An additional 6 samples of the ALL, capsule, and IGHL were procured for histologic analysis and determination of elastin content. RESULTS: All investigated mechanical properties were significantly greater for both the ALL and IGHL when compared with capsular tissue. In contrast, no significant differences between the ALL and IGHL were found for any property. The elastic modulus of ALL and IGHL samples was 174 ± 92 MPa and 139 ± 60 MPa, respectively, compared with 62 ± 30 MPa for the capsule (P = .001). Ultimate stress was significantly lower (P < .001) for the capsule, at 13.4 ± 7.7 MPa, relative to the ALL and IGHL, at 46.4 ± 20.1 MPa and 38.7 ± 16.3 MPa, respectively. The ultimate strain at failure was 37.8% ± 7.9% for the ALL and 39.5% ± 9.4% for the IGHL; this was significantly greater (P = .041 and P = .02, respectively) for both relative to the capsule, at 32.6% ± 8.4%. The strain energy density was 7.8 ± 3.1 MPa for the ALL, 2.1 ± 1.3 MPa for the capsule, and 7.1 ± 3.1 MPa for the IGHL (P < .001). The ALL and IGHL consisted of collagen bundles aligned in a parallel manner, containing elastin bundles, which was in contrast to the random collagen architecture noted in capsule samples. CONCLUSIONS: The ALL has similar tensile and histologic properties to the IGHL. The tensile properties of the ALL are significantly greater than those observed in the knee capsule. CLINICAL RELEVANCE: The ALL is not just a thickening of capsular tissue and should be considered a distinct ligamentous structure comparable to the IGHL in the shoulder. The tensile behavior of the ALL is similar to the IGHL, and treatment strategies should take this into account.


Subject(s)
Knee Joint/physiology , Ligaments, Articular/physiology , Shoulder Joint/physiology , Aged , Aged, 80 and over , Biomechanical Phenomena , Cadaver , Female , Humans , Joint Capsule/anatomy & histology , Joint Capsule/physiology , Knee Joint/anatomy & histology , Ligaments, Articular/anatomy & histology , Male , Shoulder Joint/anatomy & histology , Tensile Strength/physiology
8.
Acta Orthop Belg ; 80(2): 166-71, 2014 Jun.
Article in English | MEDLINE | ID: mdl-25090787

ABSTRACT

UNLABELLED: It has been demonstrated that the use of echography during intra-articular shoulder infiltrations provides superior results. The correct infiltration technique and the related (contra-) indications are still under discussion. The authors' objective was to ascertain how intra-articular shoulder infiltrations are done in Holland and Flanders. An electronic questionnaire was answered by 35 members of the FLESSS (Flanders) and 30 members of the WSE (Netherlands) and was then processed statistically. RESULTS: 21.54% of those questioned think they have sufficient experience with the use of echography during intra-articular infiltrations. 87.7% of the orthopaedists give a normal dose of corticoids to diabetes patients and more than 71% infiltrate when anticoagulants are used. Whereas 68.57% of the Flemish use posterior infiltration, 76.67% of the Dutch give an anterior injection. CONCLUSIONS: Echography is not used enough as an aid for intra-articular shoulder infiltrations. Neither diabetes mellitus nor anticoagulants are considered to be contra-indications. The Flemish shoulder specialists mainly administer posterior infiltration with methylprednisolone. The Dutch orthopaedists mainly administer anterior infiltration with triamcinolone.


Subject(s)
Injections, Intra-Articular/methods , Orthopedics , Practice Patterns, Physicians' , Shoulder Joint , Specialization , Humans , Netherlands , Shoulder Joint/diagnostic imaging , Ultrasonography
9.
Br J Sports Med ; 46(15): 1078-83, 2012 Dec.
Article in English | MEDLINE | ID: mdl-22842236

ABSTRACT

BACKGROUND: Football turf is increasingly used in European soccer competition. Little is known on the rotational torque that players experience on these fields. High rotational torques between the shoe outsole and the sports surface has been correlated with torsional injuries of the lower limb and knee. PURPOSE: To evaluate the effect of six parameters that could influence the rotational torque between the shoe outsole and the latest generation football turf. STUDY DESIGN: Controlled laboratory study. METHODS: A testing apparatus was constructed to measure the peak torque generated during a controlled rotation of the foot. Six parameters that could potentially influence the frictional forces, were considered: (1) the sports surface, (2) the shoe outsole cleat design, (3) the weather conditions, (4) the weight, (5) the presence of an impact and (6) the direction of rotation. RESULTS: The football turf without infill showed significantly lower frictional torques than natural grass whereas a football turf with sand/rubber infill had significantly higher torques. Blades were associated with significantly higher torques than studs on natural grass and on one football turf with sand/rubber infill. Dry weather was associated with higher torques only for the football turf without infill. The torque increased linearly and significantly with an increasing vertical load. The rotational torque increased significantly following an impact. Torques on external rotational movements were significantly higher with blades. CONCLUSIONS: Important differences in rotational torques are found and could be seen as potential risk factors for torsional injuries of the lower limb.


Subject(s)
Leg Injuries/etiology , Shoes , Soccer/injuries , Sports Equipment , Torsion Abnormality/physiopathology , Body Weight/physiology , Equipment Design , Female , Floors and Floorcoverings , Friction , Humans , Leg Injuries/physiopathology , Leg Injuries/prevention & control , Male , Torque , Torsion Abnormality/etiology
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