[The evaluation of susceptibility to oxidation of selected lipoproteins of pregnant women with type B diabetes mellitus in 2nd and 3rd trimester of pregnancy]. / Ocena podatnosci na proces oksydacji wybranych lipoprotein u ciezarnych chorych na cukrzyce klasy B w II i III trymestrze ciazy.

OBJECTIVES AND DESIGN: The aim of study was estimation of susceptibility on the process of oxidation of selected lipoproteins of pregnant women with IDDM in II, III trimester of pregnancy. MATERIALS AND METHODS: Study included 80 women. Patients were divided into four groups: pregnant with IDDM, pregnant healthy, nonpregnant with and without IDDM. We used spectrophotometric method for estimation of susceptibility on oxidation of HDL, LDL in the four groups of patients. RESULTS: In the group of diabetic pregnant we found increased serum concentrations of LDL. The comparison of examined groups showed statistically significant higher susceptibility on the oxidation of chosen lipoproteins in pregnant with IDDM. This group of patients characterized lower antioxidation activity than other groups. CONCLUSIONS: Diabetic pregnant characterized higher serum concentrations of LDL, and increase of peroxidation of lipids than other groups. This group showed lower total antioxidation activity. In the groups of diabetic women we obtained increased suspectibility of oxidation LDL and HDL.