Subject(s)
Endometritis/mortality , Maternal Health Services/organization & administration , Peritonitis/mortality , Puerperal Infection/mortality , Adult , Diagnosis, Differential , Diagnostic Errors , Endometritis/diagnosis , Endometritis/prevention & control , Female , Humans , Maternal Health Services/standards , Maternal Mortality , Peritonitis/diagnosis , Peritonitis/prevention & control , Pregnancy , Prognosis , Puerperal Infection/diagnosis , Puerperal Infection/prevention & control , Russia , Time FactorsSubject(s)
Bacterial Infections/prevention & control , Cesarean Section/adverse effects , Endometritis/prevention & control , Surgical Wound Infection/prevention & control , Anti-Bacterial Agents/administration & dosage , Bacterial Infections/etiology , Chlorhexidine/administration & dosage , Endometritis/etiology , Female , Humans , Peritoneal Lavage/methods , Postoperative Care , Pregnancy , Surgical Wound Infection/etiologySubject(s)
Anti-Bacterial Agents/therapeutic use , Puerperal Infection/drug therapy , Female , Humans , PregnancyABSTRACT
Mechanisms of absorption, distribution and excretion of methicillin, oxacillin and cephaloridin were studied in 46 women with postnatal mastitis (serous and infiltrative forms). The results obtained allow one to document different clinical efficiency of antibiotics in treatment of patients with postnatal mastitis. Poor efficiency of cephaloridin in therapy of mastitis was shown.
Subject(s)
Cephaloridine/metabolism , Mastitis/metabolism , Methicillin/metabolism , Oxacillin/metabolism , Puerperal Infection/metabolism , Adult , Female , Humans , Kinetics , Milk, Human/metabolism , Pregnancy , Time FactorsABSTRACT
Features of absorption, distribution and excretion of methicillin, oxacillin and cephaloridine in 58 puerpera were studied. No complications were observed in the postnatal period of the puerpera. The results of the study of the antibiotic pharmacokinetics provided elaboration of the optimal regimen for the use of methicillin, oxacillin and cephaloridine in puerpera, i. e. I g intramuscularly every 6 hours.
Subject(s)
Cephalosporins/metabolism , Methicillin/metabolism , Oxacillin/metabolism , Puerperal Infection/metabolism , Absorption , Adult , Biopharmaceutics , Dose-Response Relationship, Drug , Female , Humans , Kinetics , Pregnancy , Time FactorsABSTRACT
The effect of some semi-synthetic penicillins, such as methicillin and oxacillin and cephalosporings, such as cephaloridin on the condition of the blood coagulation system in 85 patients with postnatal mastitis and endomyometritis was studied. It was shown that the above antibiotics had no significant effect on the parameters of the blood coagulating system. A decrease in the fibrinogen level was found in the mastitis patients treated with semi-synthetic penicillins and cephaloridin. An increase in the prothrombins index in the patients treated with methicillin oxacillin was shown. The use of the semi-synthetic penicillins and cephaloridin for the therapy of the puerpera with endomyometritis resulted in prolongation of the recalcification period. A decrease in the fibrinolytic activity most pronounced in therapy with cephaloridin was also found. Therefore, the above changes in the blood coagulating system of the puerpera with postnatal infections subjected to short-term treatment courses were insignificant and required no special correction.
Subject(s)
Blood Coagulation/drug effects , Cephaloridine/therapeutic use , Penicillins/therapeutic use , Puerperal Infection/drug therapy , Adolescent , Adult , Blood Coagulation Tests , Clinical Trials as Topic , Drug Evaluation , Endometritis/drug therapy , Female , Humans , Mastitis/drug therapy , Methicillin/therapeutic use , Oxacillin/therapeutic use , PregnancyABSTRACT
The effect of semisynthetic penicillins, such as methicillin and oxacillin and cephalosporins, such as cephaloridin of immunity and protein metabolism was studied on 63 patients with postnatal mastitis and endomyometritis. It was shown that the above antibiotics had no significant effect on the immunological reactivity and protein metabolism. However, lower titers of alpha-antitoxin, lysine levels and C-reactive protein content were registered in the mastitis patients treated with cephaloridin. Therefore, while recomending antibacterial drugs their effect on the immunity and protein metabolism should be taken into account and from this point of view semisynthetic penicillins are preferable in treatment of mastitis patients and semisynthetic penicillins and cephaloridin are preferable in treatment of endomyometritis patients.
