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N Z Med J ; 83(558): 114-6, 1976 Feb 25.
Article in English | MEDLINE | ID: mdl-131917

ABSTRACT

Current medication for Huntingtons chorea is based on compounds which affect the activity of acetylcholine and dopamine in the basal ganglia and is unsatisfactory. This report describes a small clinical trial of dopamine antagonists, tetrabenazine (Nitoman) and pimozide (Orap). Improvement was early and striking but was not maintained over the trial period of 83 weeks.


Subject(s)
Huntington Disease/drug therapy , Pimozide/therapeutic use , Tetrabenazine/therapeutic use , Adult , Drug Therapy, Combination , Female , Humans , Male , Pilot Projects , Pimozide/administration & dosage , Placebos , Tetrabenazine/administration & dosage
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