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Cell Reprogram ; 20(6): 329-336, 2018 12.
Article in English | MEDLINE | ID: mdl-31251672

ABSTRACT

This prospective clinical case series aimed to investigate the safety and efficacy of suprachoroidal adipose tissue-derived mesenchymal stem cell (ADMSC) implantation in patients with dry-type age-related macular degeneration (AMD) and Stargardt's macular dystrophy (SMD). This study included four patients with advanced-stage dry-type AMD and four patients with SMD who underwent suprachoroidal implantation of ADMSCs. The best-corrected visual acuity (BCVA) in the study was 20/200. The worse eye of the patient was operated on. Patients were evaluated on the first day, first week, and first, third, and sixth months postoperatively. BCVA, anterior segment and fundus examination, color photography, fundus autofluorescence, optical coherence tomography, and visual field examination were carried out at each visit. Fundus fluorescein angiography and multifocal electroretinography (mf-ERG) recordings were performed at the end of the first, third, and sixth months and anytime if necessary during the follow-up. All eight patients completed the sixth month follow-up. None of them had any systemic or ocular complications. All of the eight patients experienced visual acuity improvement, visual field improvement, and improvement in mf-ERG recordings. Stem cell treatment with suprachoroidal implantation of ADMSCs seems to be safe and effective in the treatment of dry-type AMD and SMD.


Subject(s)
Adipose Tissue , Geographic Atrophy/surgery , Macular Degeneration/congenital , Mesenchymal Stem Cell Transplantation , Adult , Aged , Electroretinography , Female , Fluorescein Angiography , Follow-Up Studies , Geographic Atrophy/diagnostic imaging , Geographic Atrophy/pathology , Geographic Atrophy/physiopathology , Humans , Macular Degeneration/diagnostic imaging , Macular Degeneration/pathology , Macular Degeneration/physiopathology , Macular Degeneration/surgery , Male , Middle Aged , Prospective Studies , Recovery of Function , Stargardt Disease , Time Factors , Tomography, Optical Coherence
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