Retrospective single-surgeon study of outcomes after laparoendoscopic single-site cholecystectomy and sigmoidectomy.

PURPOSE: Laparoendoscopic single-site (LESS) surgery is performed through a single port but requires a larger incision than conventional laparoscopy, which theoretically increases the risk of laparoscopic port hernia. Our primary objective is to determine the trocar site hernia rate among our patients. METHODS: This retrospective study is based on the analysis of demographic, intraoperative, and postoperative data of 219 patients who underwent cholecystectomy or sigmoidectomy by LESS surgery between December 1st, 2009 and November 30th, 2012. RESULTS: Cholecystectomy and sigmoidectomy LESS surgery were performed on 190 and 29 patients, respectively. Three patients developed a trocar site hernia within a median follow-up time of 34.7 months. Eleven patients were obese, 20 had a history of abdominal surgery, and 20 had a preoperative umbilical hernia but none of them developed a trocar site hernia, neither did the 11 subsequently pregnant women. Significant association was found between preoperative umbilical hernia and early complications including incisional cellulitis and hematoma. CONCLUSIONS: A rate of 1.4% of trocar site hernia was observed in our study population. This rate is similar to the one reported after conventional laparoscopy. Peri-umbilical incision, longer than that with conventional laparoscopy, allowed better preexisting hernia handling, made anatomical closing easier among obese patients, and facilitated specimen extraction thus limiting traumatic operations.

[Salpingo-oophorectomy by laparoendoscopic single-site surgery for everybody]. / L'annexectomie par cœlio-chirurgie mono-trocart pour tous.

OBJECTIVES: To study the adnexectomy by laparoendoscopic single-site surgery with conventional laparoscopic instruments, we standardised the technique of salpingo-oophorectomy. PATIENTS AND METHODS: In this prospective study, all patients with adnexectomies from June 2010 to January 2014 were included. Laparoendoscopic single-site adnexectomy with conventional instruments is described step by step in order to make it available for the majority of gynecologic surgeons. Laparoconversions and complications are also noted. RESULTS: We realized 42 bilateral salpingo-oophorectomies, 16 single salpingo-oophorectomy. The average operative time was 45min (15-120) with negligible blood losses. There were no laparoconversions and very few complications. After 15-20 adnexectomies, the procedure took less and less time. DISCUSSION AND CONCLUSION: Adnexectomy by laparoendoscopic single-site surgery procedure with conventional laparoscopic instruments is easily reproducible with standardized steps and has many advantages.

[Day case laparoscopic sacral colpopexy for genital prolapse]. / Prise en charge ambulatoire de la promontofixation laparoscopique pour prolapsus génital.

OBJECTIVE: To demonstrate the feasibility of day case laparoscopic sacral colpopexy with the help of a fast tracking protocol. METHODS: Three motivated patients suffering from external cystocele have been strictly selected from September 2011 to October 2011 according to criteria such as Body Mass Index, ASA score, comorbidities et French day case rules. Laparoscopic sacral colpopexies consisted in anterior and posterior polyesther meshes sutured with non-resorbable wires. We are used to proceed through a SILS(©) unique ombilical port. We have used standard and straight laparoscopic instruments and laparoscope. The bladder catheter has been removed two hours after surgery, the patients have been encouraged to stand up and they have received a light meal before Chung score has been quoted. The patients have been discharged in the evening before 7 pm. RESULTS: The patients are 65, 67 and 66 years old, two of them had a past history of pelvic surgery. We did not deplore any complication during the procedure, no blood loss, no laparoscopic conversion (additional trocar); the procedures durations were 92, 120 and 124 min. These three patients have not been readmitted. Clinical examination has been scheduled between 6 and 8 weeks after surgery. We did not describe any pelvic or parietal complication, no early recurrence. CONCLUSION: We have demonstrated here the feasibility in good security conditions of day case laparoscopic sacral colpopexy for genital prolapse. A fast tracking protocol is essential and selecting the patients is required.

[Feasibility of laparoendoscopic single-site surgery in gynecology with conventional laparoscopic instruments]. / Faisabilité de la cœliochirurgie gynécologique par mono-trocart avec instruments droits standards.

OBJECTIVES: To describe the safety and efficacy of single-port access for laparoscopic surgery in gynecology with conventional laparoscopic instruments. PATIENTS AND METHODS: In this prospective study, we report our experience with 90 patients who underwent Single Port Access (SPA) laparoscopic surgery for gynecologic pathology with the use of the SILS(®) Port Multiple Instrument Access Port (Covidien(®), Mansfield, MA). RESULTS: We realised 15 ovarian cystectomies, 30 salpingo-oophrectomies with 14 one side, 9 lysis of adhesions, 7 distal tubal repairs, 6 salpingectomy, 8 other procedures. The mean surgical time is 47 min (25-120). One conversion to conventional laparoscopy and one in laparotomy were performed. The mean duration stay is 2 days [1-3]. DISCUSSION AND CONCLUSION: SPA in gynecology is feasible with conventional laparoscopic instruments. SPA surgery represents the newest frontier in minimally invasive surgery.

Effects of amino acid combinations on the development of organotypic culture of the myocardium from young and old rats.

Effects of 20 L-amino acids in concentration of 0.05 ng/ml on the development of myocardium of young (3-month-old) and old (24-month-old) rats in organotypic tissue culture were investigated. Stimulation of cell proliferation in the myocardium of young animals appeared under the influence of asparagine, histidine, serine, lysine, arginine, glutamic acid, and isoleucine. In the myocardium of old rats, proliferative effects remained only for two amino acids, lysine and arginine. Combinations of one stimulating and one inactive amino acids effectively increase the stimulating effect in both young and old rats. Modulating properties of amino acids and their combinations provide the basis for the synthesis of peptides regulating regenerative processes in the myocardium, particularly during aging.

Colorectal cancer in Russian-speaking Jewish emigrés: community-based screening.

OBJECTIVES: Colorectal cancer (CRC) screening by fecal occult blood testing and flexible sigmoidoscopy is recommended by many authorities for those older than age 50. Ashkenazi Jews have been shown to have a higher level of CRC and polyps than the general population. A subset of Ashkenazi Jews, Russian-speaking Jewish immigrants to the United States (RJIs), have not been studied extensively for CRC and may have additional risk factors not found in other Ashkenazi populations. METHODS: A retrospective chart review was undertaken of fecal occult blood tests, endoscopy reports, and pathology reports of 132 RJIs and 124 non-RJI controls over age 50 between 1987 and 1999 at the Jewish Hospital of Cincinnati Medical Outpatient Clinic. RESULTS: Mean ages at the time of diagnosis or flexible sigmoidoscopy were 68 yr for RJIs and 66 yr for the non-RJI patients. Of the RJI patients, 38.7% had positive findings: 37 (28.0%) with lesions < 2 cm, five (3.8%) with lesions > 2 cm, and nine (6.8%) with CRC. Of the non-RJI control group patients, 16.9% had positive findings: 16 (12.9%) with lesions < 2 cm, three (2.4%) with lesions > 2 cm, and two (1.6%) with CRC. Age- and sex-matched statistical analysis revealed significantly greater CRC and significantly more polyps > 2 cm for the RJI patients (p < 0.003). This is higher than in other studies of Ashkenazis, which show a 2.3% incidence, and in statistics from the National Cancer Institute, which reveal a national CRC incidence rate for those over age 65 to be 0.30%. CONCLUSIONS: RJIs in our study have polyps > 2 cm and CRC at a rate of 10.6%, as compared with 4.0% for in-clinic controls and a national average of 0.30% for patients over age 65. This suggests a need for more aggressive screening of this patient population for CRC.