ABSTRACT
A comparative assessment of buffer activity of reamberin and polyoxyfumaren was made. Their influence on systemic consumption of oxygen, content of lactate in blood, parameters of central hemodynamics were followed. The research includes 44 victims (aged 25-70 years) with severe shockogenic injuries. Reamberin was included in composition of fluid therapy of I group (n=30)and polyoxyfumaren was used in 11 group (n=14). Parameters of acid-base balance of arterial blood, VO2, VCO,, contents of lactate in mixed venous blood, parameters of central hemodynamics were measured in monitor regimen before the infusion. It was proved, that the intravenous infusion of reamberin and polyoxyfumaren accompanied by reliable rise of minute consumption of oxygen (27 and 18% respectively). The drugs decrease the lactate level in blood, reliably increase buffer capacity of blood, correct the metabolic acidosis. Both antihy-poxanthines allow the increase of minute volume of circulation: reamberin on 15%, polyoxyfumaren on 34,9%. The volemic effect of polyoxyfumaren resulted in the increase of circular plasma volume after finishing the infusion on 49,5%, in the case of reamberin - on 16%.
Subject(s)
Meglumine/analogs & derivatives , Polyethylene Glycols , Reperfusion Injury , Reperfusion , Shock, Traumatic , Succinates , Acid-Base Equilibrium/drug effects , Administration, Intravenous , Adult , Blood Substitutes/administration & dosage , Blood Substitutes/adverse effects , Comparative Effectiveness Research , Drug Therapy, Combination , Female , Fluid Therapy/methods , Hemodynamics/drug effects , Humans , Male , Meglumine/administration & dosage , Meglumine/adverse effects , Middle Aged , Polyethylene Glycols/administration & dosage , Polyethylene Glycols/adverse effects , Reperfusion/adverse effects , Reperfusion/methods , Reperfusion Injury/metabolism , Reperfusion Injury/physiopathology , Reperfusion Injury/prevention & control , Shock, Traumatic/metabolism , Shock, Traumatic/physiopathology , Shock, Traumatic/therapy , Succinates/administration & dosage , Succinates/adverse effects , Trauma Severity Indices , Treatment OutcomeABSTRACT
In patients with severe cranio-cerebral traumas an investigation was performed of the efficiency of using vasoactive therapy in complex treatment directed to earlier recovery of the microcirculatory blood flow and aerobic metabolism in ischemic parts of the brain.
Subject(s)
Aerobiosis/drug effects , Alprostadil/administration & dosage , Brain Ischemia , Craniocerebral Trauma , Microcirculation/drug effects , Respiratory Therapy/methods , Adult , Brain Ischemia/diagnosis , Brain Ischemia/etiology , Brain Ischemia/metabolism , Brain Ischemia/physiopathology , Brain Ischemia/therapy , Cerebrovascular Circulation/drug effects , Combined Modality Therapy/methods , Craniocerebral Trauma/complications , Craniocerebral Trauma/diagnosis , Craniocerebral Trauma/metabolism , Craniocerebral Trauma/physiopathology , Drug Monitoring , Glasgow Coma Scale , Humans , Laser-Doppler Flowmetry , Male , Middle Aged , Neuroprotective Agents/therapeutic use , Treatment Outcome , Vasodilator Agents/administration & dosageSubject(s)
Drug Therapy, Combination , Multiple Organ Failure , Multiple Trauma/complications , Shock, Traumatic/physiopathology , Shock, Traumatic/therapy , Surgical Procedures, Operative , Combined Modality Therapy , Humans , Multiple Organ Failure/etiology , Multiple Organ Failure/physiopathology , Multiple Organ Failure/prevention & control , No-Reflow Phenomenon/etiology , No-Reflow Phenomenon/physiopathology , Shock, Traumatic/etiologyABSTRACT
Here we have analyzed the results of surgical treatment of gallstone disease and its complications in 1208 senior-age patients. In 875 patients planned operations were performed, whereas in 333 patients the interventions were urgent. Post operational complications occurred in 5.2% of cases, and lethality amounted to 4.1%. The complications and post operational lethality depended on how traumatic and urgent the intervention was. Diagnostics of intraperitoneal complications was based on instrumental examination methods, with primary significance assigned to laparoscopy. In 21 patients early post operational intraperitoneal complications were treated with the use of mini-invasive methods. Guidelines for surgical treatment of gallstone disease and its complications in senior patients have been worked out.
