[A role of cytokines in the regulation of an immune response and the mechanisms of ß-cell death in different variants of the course of typ 1 diabetes mellitus].

In recent years, in molecular biology there has been a shift in priorities towards deciphering the mechanisms of realization of genetic information. As a result, research has come to the fore regarding the transmission of signals between cells and within each cell.

[Combined therapy for type 2 diabetes mellitus].

The development of diabetes is preceded by a number of stages of impaired carbohydrate tolerance. From the state of normal through the stage of impaired glucose tolerance, the development of type 2 diabetes mellitus, diabetes complications, the disease leads to death. With this understanding of the disease, the question arises: is it possible to prevent diabetes and its complications? With regard to type 2 diabetes, the answer is yes. Primary disease prevention involves exposure before the onset of the disease; the presence of a specific target, i.e., an etiological determinant; continued effect after discontinuation of therapy.The results of many studies have been published, which convincingly proved that drug and non-drug effects can prevent the transition of the stage of impaired glucose tolerance into diabetes mellitus.

[Diabetes mellitus-associated genetic syndromes: Wolfram's syndrome].

Wolfram syndrome - a progressive neurodegenerative disease that combines nonautoimmune insulin-dependent diabetes mellitus and optic atrophy.