1.
Vopr Virusol
; (3): 306-8, 1979.
Article
in Russian
| MEDLINE
| ID: mdl-462929
Subject(s)
Adamantane/pharmacology , Bridged-Ring Compounds/pharmacology , Influenza A Virus, H1N1 Subtype , Influenza A virus/drug effects , Adamantane/analogs & derivatives , Animals , Chick Embryo , Dogs , Dose-Response Relationship, Drug , Kidney , Viral Proteins/antagonists & inhibitors , Virus Cultivation , Virus Replication/drug effects
2.
Vopr Med Khim
; 25(2): 193-8, 1979.
Article
in Russian
| MEDLINE
| ID: mdl-442590
ABSTRACT
Methotrexate was shown to inhibit development of Rausher's leukosis and growth of spleen. Activity of DNA-dependent RNA polymerases A and B was distinctly altered. The activity of RNA polymerase B was increased two-fold within the first days of the leukosis development; RNA polymerase A was activated five-fold in the course of subsequent progression of the impairment. Methotrexate inhibited the RNA polymerase activity in leukemic spleens. As suggested by correlation between weight of the spleen and the activity of RNA polymerases A and B, the enzymatic activity may be considered as a marker of the leukosis development.
Subject(s)
DNA-Directed RNA Polymerases/metabolism , Leukemia, Experimental/drug therapy , Methotrexate/therapeutic use , Spleen/enzymology , Animals , Leukemia, Experimental/enzymology , Mice , Mice, Inbred BALB C , Rauscher Virus
3.
Lancet
; 1(8110): 269-70, 1979 Feb 03.
Article
in English
| MEDLINE
| ID: mdl-84920