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An enzymatic route to 5-deoxy-5-[18F]fluoro-D-ribose, a [18F]-fluorinated sugar for PET imaging.
Onega, Mayca; Domarkas, Juozas; Deng, Hai; Schweiger, Lutz F; Smith, Timothy A D; Welch, Andrew E; Plisson, Christophe; Gee, Antony D; O'Hagan, David.
Chem Commun (Camb) ; 46(1): 139-41, 2010 Jan 07.
Article in English | MEDLINE | ID: mdl-20024319

ABSTRACT

An efficient two-step, one-pot, biotransformation involving the fluorinase enzyme is described for the synthesis of 5-deoxy-5-[(18)F]fluororibose, a novel [(18)F]-fluorinated sugar suitable for positron emission tomography (PET) applications.


Subject(s)
Bacterial Proteins/metabolism , N-Glycosyl Hydrolases/metabolism , Oxidoreductases/metabolism , Positron-Emission Tomography , Ribose/analogs & derivatives , Biocatalysis , Cell Line, Tumor , Fluorine Radioisotopes/chemistry , Halogenation , Humans , Ribose/chemical synthesis , Ribose/chemistry
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