Subject(s)
Air Pollutants/adverse effects , Air , Employment , Hazardous Waste/adverse effects , Insecticides/analysis , Insecticides/toxicity , Occupational Health , Pyrethrins/analysis , Pyrethrins/toxicity , Animals , Female , Humans , Male , Maximum Allowable Concentration , Mice , Permethrin , RatsABSTRACT
Reports of MACs for carboxylic acid derivatives as sodium methoxyacetate (SMOA), methyl chlorpropionate (MCP) and acetoacetic ether (AAE). SMOA shows low toxicity, no cumulation and specific action MCP demonstrates moderate toxicity, low cumulation no specific action in concentrations close to Limac. AAE presents toxicity low in oral usage and moderate when inhaled, low cumulation, no irritation and sensitization. Tentative safe level of injury and MAC estimated for the aforesaid substances together with toxicity parameters compared with the substances studied before allowed the authors to set the MAC of SMOA--10, MCP--2, AAE--10 mg/m3.
Subject(s)
Air Pollutants, Occupational/toxicity , Carboxylic Acids/toxicity , Models, Biological , Acetates/toxicity , Acetoacetates/toxicity , Animals , Dose-Response Relationship, Drug , Guinea Pigs , Hydrocarbons, Chlorinated , Lethal Dose 50 , Mathematics , Maximum Allowable Concentration , Mice , Propionates/toxicity , RatsSubject(s)
Acetates/toxicity , Air Pollutants, Occupational/toxicity , Butyrates/toxicity , Chemical Industry/standards , Methyl Ethers/toxicity , Propionates/toxicity , Valerates/toxicity , Acetates/analysis , Acetates/standards , Air Pollutants, Occupational/analysis , Butyrates/analysis , Butyrates/standards , Humans , Maximum Allowable Concentration , Methyl Ethers/analysis , Methyl Ethers/standards , Propionates/analysis , Propionates/standards , Regression Analysis , Valerates/analysis , Valerates/standardsABSTRACT
Proceeding from the experimental study of neopinamine insecticide toxicity its hygienic standardization was carried out. Since neopinamine had moderate toxicity under its acute and chronic effect and different routes of body intake, its accumulation was absent and its impact was selective in the occurrence of aftereffects, this preparation was attributed to the third class of danger. Neopinamine MAC in the workplace air was recommended at the level of 5 mg/m3.