ABSTRACT
We compared bioavailability of 4-methyl-2,6-diisobornylphenol after single intragastric administration to rats in a dose of 200 mg/kg in starch suspension and in almond oil. Absorption of 4-methyl-2,6-diisobornylphenol in the gastrointestinal tract after administration in almond oil was much more efficient than after administration in aqueous starch mucus.
Subject(s)
Antioxidants/administration & dosage , Antioxidants/pharmacokinetics , Camphanes/administration & dosage , Camphanes/pharmacokinetics , Cresols/administration & dosage , Cresols/pharmacokinetics , Phenols/administration & dosage , Phenols/pharmacokinetics , Administration, Oral , Animals , Gastrointestinal Tract/metabolism , Intestinal Absorption/drug effects , Male , Plant Oils/chemistry , Rats , Rats, WistarABSTRACT
Hemorheological activity of 4-methyl-2,6-di-isobornyl phenol, a new o-isobornyl phenol derivative, was studied under conditions of experimental prolonged partial cerebral ischemia. Brain ischemia is associated with hemorheological disorders which can be characterized as blood hyperviscosity syndrome: increased viscosity of the whole blood (within a wide range of shear rates), plasma viscosity, fibrinogen content in blood plasma, and platelet aggregation; deterioration of platelet deformability and reduced availability of oxygen for tissues. A course (5 days) of intragastric 4-methyl-2,6-di-isobornyl phenol (100 mg/kg) prevented the development of blood hyperviscosity syndrome by modulating blood macrorheology (reduction of plasma viscosity and fibrinogen content) and microrheology (reduction of erythrocyte aggregation and improvement of their deformability).
Subject(s)
Brain Ischemia/drug therapy , Phenols/therapeutic use , Rheology , Animals , Male , Rats , Rats, WistarABSTRACT
Along with microangiopathy, one of the main causes of blindness in diabetic retinopathy consists of degeneration of retinal neurons. Electron microscopy and morphometric analysis were used to study structural changes in neurosensory cells, associative, and ganglion neurons in the retina in 30 while mongrel male rats with streptozotocin diabetes for two months and the effects of a new semisynthetic antioxidant 4-methyl-2,6-diisobornylphenol, a screened phenol, were evaluated. Destructive changes were found to affect the outer segments of neurosensory cells and ganglion neurons. The number density of neurosensory and ganglion cells decreased, and the proportion of these cells with pyknotic nuclei increased. 4-Methyl-2,6-diisobornylphenol had neuroprotective actions, preventing destructive changes to neurosensory cells and ganglion neurons.
Subject(s)
Camphanes/therapeutic use , Cresols/therapeutic use , Diabetes Mellitus, Experimental/complications , Diabetic Retinopathy/drug therapy , Neuroprotective Agents/therapeutic use , Retinal Neurons/drug effects , Animals , Camphanes/pharmacology , Cresols/pharmacology , Diabetes Mellitus, Experimental/pathology , Diabetic Retinopathy/etiology , Diabetic Retinopathy/pathology , Male , Neuroprotective Agents/pharmacology , Rats , Retinal Neurons/pathology , StreptozocinABSTRACT
We studied antithrombogenic and antiplatelet properties of 4-methyl-2,6-diisobornyl phenol, a new promising compound belonging to ortho-isobornyl phenol derivatives, under conditions of intravascular thrombosis and acute cerebral ischemia. It was found that 4-methyl-2,6-diisobornyl phenol prevents intravascular thrombus formation by reducing platelet aggregation and improving antiplatelet activity of the vascular wall.
