ABSTRACT
The performance of the insular system of the pancreatic gland was studied in 111 pulmonary tuberculosis patients who suffered from diabetes mellitus as were the functions of thyroid and pituitary-adrenal glands assessed by the blood content of C-peptide, T3, T4, TTH, ACTH and circadian excretion of 17-OCS. It was stated that the combined pathology was accompanied with pronounced endocrine disorders, pancreatic incretory function was found to be depended both on the pattern and severity of diabetes mellitus course and clinical manifestations of pulmonary tuberculosis. In combined disease high frequency of absolute and relative insufficiency of hypophyseal adrenocortical performance and adrenal glucocorticoid performance occurs. Revealed disorders were found to be depended on the clinical patterns of pulmonary tuberculosis and the type of diabetes mellitus as well as on the duration and severity of the course of both conditions. Combined pathology was frequently (60%) accompanied with the development of hypothyrosis manifested by the reduction of T3 content in the blood serum, imbalance of thyroid hormones (elevation of T4 to T3 ratio). The disorders mentioned were mostly manifest in patients with severe course of the combined pathology. Hypothyrosis aggravated a therapeutic prognosis for tuberculosis in diabetic patients. The treatment of both conditions performed with regard to the character of endocrine disorders was of great aid in reaching the improvement in the course of pulmonary tuberculosis in 92.8%.
Subject(s)
Diabetes Mellitus/physiopathology , Tuberculosis, Pulmonary/complications , Adolescent , Adult , Diabetes Complications , Humans , Middle Aged , Pancreas/physiopathology , Pituitary-Adrenal System/physiopathology , Thyroid Gland/physiopathologySubject(s)
Tuberculosis/epidemiology , Adolescent , Adult , Age Factors , Aged , Child , Humans , Middle Aged , Recurrence , Risk Factors , Tuberculosis/drug therapy , Tuberculosis/etiology , USSRSubject(s)
Tuberculosis, Pulmonary/therapy , Adolescent , Adult , Aged , Combined Modality Therapy , Female , Humans , Middle Aged , Tuberculosis, Pulmonary/etiologyABSTRACT
A study was made of levels of malonic dialdehyde, peroxide hemolysis of erythrocytes, superoxide dismutase activity and a tocopherol content for the purpose of investigating the state of lipid peroxidation in 14 patients with type I diabetes mellitus. Correlation between the state of lipid peroxidation and a degree of diabetes mellitus compensation was established. Decompensated diabetes mellitus was characterized by more enhanced lipid peroxidation and tocopherol deficiency.
